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PLCL2 phospholipase C like 2 [ Homo sapiens (human) ]

Gene ID: 23228, updated on 23-Aug-2020

Summary

Official Symbol
PLCL2provided by HGNC
Official Full Name
phospholipase C like 2provided by HGNC
Primary source
HGNC:HGNC:9064
See related
Ensembl:ENSG00000154822 MIM:614276
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PLCE2
Expression
Ubiquitous expression in ovary (RPKM 4.0), lymph node (RPKM 3.4) and 23 other tissues See more
Orthologs

Genomic context

See PLCL2 in Genome Data Viewer
Location:
3p24.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (16802691..17090606)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (16974582..17132098)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene endogenous retrovirus group PABLB member 1 Env polyprotein Neighboring gene CDYL pseudogene 1 Neighboring gene uncharacterized LOC105376972 Neighboring gene microRNA 3714 Neighboring gene TBC1 domain family member 5 Neighboring gene ribosomal protein L31 pseudogene 19 Neighboring gene RNA, U7 small nuclear 10 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study identifies PLCL2 and AP3D1-DOT1L-SF3A2 as new susceptibility loci for myocardial infarction in Japanese.
GeneReviews: Not available
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
GeneReviews: Not available
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
GeneReviews: Not available
Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13484, KIAA1092

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GABA receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
inositol 1,4,5 trisphosphate binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
B cell proliferation involved in immune response IEA
Inferred from Electronic Annotation
more info
 
B-1a B cell differentiation IEA
Inferred from Electronic Annotation
more info
 
gamma-aminobutyric acid signaling pathway IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of B cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of receptor binding IEA
Inferred from Electronic Annotation
more info
 
regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of synaptic transmission, GABAergic IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
inactive phospholipase C-like protein 2
Names
PLC-L(2)
PLC-L2
PLC-epsilon-2
phospholipase C-L2
phospholipase C-epsilon-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144382.2NP_001137854.1  inactive phospholipase C-like protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001137854.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB029015, AEKP01168581, N93050
    Consensus CDS
    CCDS74911.1
    UniProtKB/Swiss-Prot
    Q9UPR0
    Related
    ENSP00000478458.1, ENST00000615277.5
    Conserved Domains (4) summary
    cd00275
    Location:753881
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08597
    Location:425721
    PI-PLCc_PRIP_metazoa; Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein
    cd13364
    Location:143251
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd16223
    Location:271414
    EFh_PRIP2; EF-hand motif found in phospholipase C-related but catalytically inactive protein 2 (PRIP-2)
  2. NM_015184.5NP_055999.2  inactive phospholipase C-like protein 2 isoform 2

    See identical proteins and their annotated locations for NP_055999.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AB029015, BC036392, N93050
    Consensus CDS
    CCDS33713.1
    UniProtKB/Swiss-Prot
    Q9UPR0
    Related
    ENSP00000412836.1, ENST00000432376.5
    Conserved Domains (4) summary
    cd00275
    Location:627755
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08597
    Location:299595
    PI-PLCc_PRIP_metazoa; Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein
    cd13364
    Location:17125
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd16223
    Location:145288
    EFh_PRIP2; EF-hand motif found in phospholipase C-related but catalytically inactive protein 2 (PRIP-2)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    16802691..17090606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006023.1XP_016861512.1  inactive phospholipase C-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9UPR0
    Conserved Domains (4) summary
    cd00275
    Location:753881
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08597
    Location:425721
    PI-PLCc_PRIP_metazoa; Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein
    cd13364
    Location:143251
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd16223
    Location:271414
    EFh_PRIP2; EF-hand motif found in phospholipase C-related but catalytically inactive protein 2 (PRIP-2)
  2. XM_017006022.2XP_016861511.1  inactive phospholipase C-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9UPR0
    Conserved Domains (4) summary
    cd00275
    Location:753881
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08597
    Location:425721
    PI-PLCc_PRIP_metazoa; Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein
    cd13364
    Location:143251
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd16223
    Location:271414
    EFh_PRIP2; EF-hand motif found in phospholipase C-related but catalytically inactive protein 2 (PRIP-2)
  3. XM_017006024.2XP_016861513.1  inactive phospholipase C-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9UPR0
    Conserved Domains (4) summary
    cd00275
    Location:753881
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08597
    Location:425721
    PI-PLCc_PRIP_metazoa; Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein
    cd13364
    Location:143251
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd16223
    Location:271414
    EFh_PRIP2; EF-hand motif found in phospholipase C-related but catalytically inactive protein 2 (PRIP-2)
  4. XM_017006025.1XP_016861514.1  inactive phospholipase C-like protein 2 isoform X3

    UniProtKB/Swiss-Prot
    Q9UPR0
    Conserved Domains (4) summary
    cd00275
    Location:627755
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08597
    Location:299595
    PI-PLCc_PRIP_metazoa; Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein
    cd13364
    Location:17125
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd16223
    Location:145288
    EFh_PRIP2; EF-hand motif found in phospholipase C-related but catalytically inactive protein 2 (PRIP-2)
  5. XM_006713073.3XP_006713136.1  inactive phospholipase C-like protein 2 isoform X2

    Conserved Domains (6) summary
    cd00275
    Location:648776
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08597
    Location:320616
    PI-PLCc_PRIP_metazoa; Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein
    PLN02228
    Location:230778
    PLN02228; Phosphoinositide phospholipase C
    cd13364
    Location:38146
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    pfam00169
    Location:40146
    PH; PH domain
    pfam09279
    Location:238320
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_017363813.1 Reference GRCh38.p13 PATCHES

    Range
    197430..403074
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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