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DTX4 deltex E3 ubiquitin ligase 4 [ Homo sapiens (human) ]

Gene ID: 23220, updated on 13-Mar-2020

Summary

Official Symbol
DTX4provided by HGNC
Official Full Name
deltex E3 ubiquitin ligase 4provided by HGNC
Primary source
HGNC:HGNC:29151
See related
Ensembl:ENSG00000110042 MIM:616110
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF155
Expression
Ubiquitous expression in urinary bladder (RPKM 13.0), lung (RPKM 11.7) and 25 other tissues See more
Orthologs

Genomic context

See DTX4 in Genome Data Viewer
Location:
11q12.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (59171430..59208588)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (58939812..58976060)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene FAM111A divergent transcript Neighboring gene protein kinase cAMP-dependent type II regulatory subunit beta pseudogene Neighboring gene family with sequence similarity 111 member A Neighboring gene macrophage expressed 1 Neighboring gene RNA, 7SL, cytoplasmic 42, pseudogene Neighboring gene tryptophanyl-tRNA synthetase 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of deltex homolog 4 (DTX4) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0937, MGC141899

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity TAS
Traceable Author Statement
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of type I interferon production TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase DTX4
Names
RING finger protein 155
RING-type E3 ubiquitin transferase DTX4
deltex 4 homolog
deltex 4, E3 ubiquitin ligase
deltex homolog 4
deltex4
protein deltex-4
NP_001287656.1
NP_055992.1
XP_006718546.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300727.1NP_001287656.1  E3 ubiquitin-protein ligase DTX4 isoform 2

    See identical proteins and their annotated locations for NP_001287656.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate exon in place of the first exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AP002358, BC119011
    Consensus CDS
    CCDS76408.1
    UniProtKB/Swiss-Prot
    Q9Y2E6
    Related
    ENSP00000434055.1, ENST00000532982.5
    Conserved Domains (4) summary
    cd09633
    Location:370502
    Deltex_C; Domain found at the C-terminus of deltex-like
    pfam02825
    Location:138
    WWE; WWE domain
    cd16671
    Location:300366
    RING-H2_DTX1_4; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase deltex1 (DTX1), deltex4 (DTX4), and similar proteins
    cl26464
    Location:63259
    Atrophin-1; Atrophin-1 family
  2. NM_015177.2NP_055992.1  E3 ubiquitin-protein ligase DTX4 isoform 1

    See identical proteins and their annotated locations for NP_055992.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB023154, AP001258, AP002358, BF195769
    Consensus CDS
    CCDS44612.1
    UniProtKB/Swiss-Prot
    Q9Y2E6
    Related
    ENSP00000227451.3, ENST00000227451.4
    Conserved Domains (4) summary
    smart00678
    Location:886
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:476608
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd00162
    Location:408469
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam02825
    Location:90144
    WWE; WWE domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    59171430..59208588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718483.3XP_006718546.1  E3 ubiquitin-protein ligase DTX4 isoform X1

    See identical proteins and their annotated locations for XP_006718546.1

    UniProtKB/Swiss-Prot
    Q9Y2E6
    Conserved Domains (4) summary
    cd09633
    Location:370502
    Deltex_C; Domain found at the C-terminus of deltex-like
    pfam02825
    Location:138
    WWE; WWE domain
    cd16671
    Location:300366
    RING-H2_DTX1_4; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase deltex1 (DTX1), deltex4 (DTX4), and similar proteins
    cl26464
    Location:63259
    Atrophin-1; Atrophin-1 family
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