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ZFR2 zinc finger RNA binding protein 2 [ Homo sapiens (human) ]

Gene ID: 23217, updated on 11-Jun-2021

Summary

Official Symbol
ZFR2provided by HGNC
Official Full Name
zinc finger RNA binding protein 2provided by HGNC
Primary source
HGNC:HGNC:29189
See related
Ensembl:ENSG00000105278 MIM:619284
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIAA1086
Expression
Biased expression in testis (RPKM 2.0), brain (RPKM 1.5) and 1 other tissue See more
Orthologs
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Genomic context

See ZFR2 in Genome Data Viewer
Location:
19p13.3
Exon count:
21
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (3804024..3869038, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (3804022..3869036, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene retina and anterior neural fold homeobox 2 Neighboring gene megakaryocyte-associated tyrosine kinase Neighboring gene Sharpr-MPRA regulatory region 13254 Neighboring gene ferritin light chain pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1086

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger RNA-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145640.2NP_001139112.1  zinc finger RNA-binding protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) originates from the same promoter and has the same first exon and presumed translation initiation site, which has a good Kozak signal, as variant 1. However, this transcript represents an alternate second, terminal exon and the predicted protein (isoform 2) is significantly shorter than and has a distinct C-terminus as compared to isoform 1.
    Source sequence(s)
    AC093078, BC034005, DA333602
    Consensus CDS
    CCDS45922.1
    UniProtKB/Swiss-Prot
    Q9UPR6
    Related
    ENSP00000388567.1, ENST00000439086.2
  2. NM_015174.2NP_055989.1  zinc finger RNA-binding protein 2 isoform 1

    See identical proteins and their annotated locations for NP_055989.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is a longer transcript and encodes the full-length protein (isoform 1).
    Source sequence(s)
    AB029009, AC004598, AC005777, AC093078, DA333602
    Consensus CDS
    CCDS45921.1
    UniProtKB/Swiss-Prot
    Q9UPR6
    Related
    ENSP00000262961.3, ENST00000262961.9
    Conserved Domains (3) summary
    smart00572
    Location:652904
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    smart00451
    Location:271300
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:273295
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. NR_027149.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) originates from the same promoter and has the same first exon as variant 1. THis transcript includes an alternate exon which renders the transcript a candidate for nonsense-mediated decay (NMD) and so a protein is not annotated.
    Source sequence(s)
    AC093078, AL365406, DA333602
    Related
    ENST00000586578.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    3804024..3869038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527831.2XP_011526133.1  zinc finger RNA-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011526133.1

    Conserved Domains (3) summary
    smart00572
    Location:652905
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    smart00451
    Location:271300
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:273295
    ZF_C2H2; C2H2 Zn finger [structural motif]
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