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Paip2b poly(A) binding protein interacting protein 2B [ Mus musculus (house mouse) ]

Gene ID: 232164, updated on 4-May-2024

Summary

Official Symbol
Paip2bprovided by MGI
Official Full Name
poly(A) binding protein interacting protein 2Bprovided by MGI
Primary source
MGI:MGI:2386865
See related
Ensembl:ENSMUSG00000045896 AllianceGenome:MGI:2386865
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable poly(A) binding activity and translation repressor activity, mRNA regulatory element binding. Predicted to be involved in negative regulation of translational initiation. Predicted to act upstream of or within regulation of translation. Predicted to be active in cytoplasm. Is expressed in embryo. Orthologous to human PAIP2B (poly(A) binding protein interacting protein 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 21.3), CNS E14 (RPKM 18.2) and 26 other tissues See more
Orthologs
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Genomic context

See Paip2b in Genome Data Viewer
Location:
6 C3; 6 35.97 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (83783040..83808723, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (83806058..83831741, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L27 pseudogene Neighboring gene predicted gene, 53176 Neighboring gene N-acetylglucosamine kinase Neighboring gene STARR-positive B cell enhancer mm9_chr6:83781714-83782015 Neighboring gene predicted gene, 23014 Neighboring gene ribosomal protein L18 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

General gene information

Markers

Clone Names

  • MGC27648, MGC49717

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA regulatory element binding translation repressor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables poly(A) binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables translation repressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in negative regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of translation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of translational initiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
polyadenylate-binding protein-interacting protein 2B
Names
PABP-interacting protein 2B
PAIP-2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146169.2NP_666281.2  polyadenylate-binding protein-interacting protein 2B

    See identical proteins and their annotated locations for NP_666281.2

    Status: VALIDATED

    Source sequence(s)
    AK173114, BY262990, CK381272
    Consensus CDS
    CCDS20287.1
    UniProtKB/Swiss-Prot
    B9EJI7, Q69ZQ4, Q8BL93, Q91W45
    UniProtKB/TrEMBL
    A0A158RFV3
    Related
    ENSMUSP00000050404.9, ENSMUST00000058383.9
    Conserved Domains (1) summary
    pfam07145
    Location:119135
    PAM2; Ataxin-2 C-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    83783040..83808723 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)