Paip2b poly(A) binding protein interacting protein 2B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Paip2bprovided by MGI
Official Full Name: poly(A) binding protein interacting protein 2Bprovided by MGI
Primary source: MGI:MGI:2386865
See related: Ensembl:ENSMUSG00000045896 AllianceGenome:MGI:2386865
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable poly(A) binding activity and translation repressor activity, mRNA regulatory element binding. Predicted to be involved in negative regulation of translational initiation. Predicted to act upstream of or within regulation of translation. Predicted to be active in cytoplasm. Is expressed in embryo. Orthologous to human PAIP2B (poly(A) binding protein interacting protein 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 21.3), CNS E14 (RPKM 18.2) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6; 6 C3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (83783040..83808723, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (83806058..83831741, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

General gene information

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Homology

Homologs of the Paip2b gene: The Paip2b gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, zebrafish, and frog.
Orthologs from Annotation Pipeline: 459 organisms have orthologs with human gene Paip2b
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables mRNA regulatory element binding translation repressor activity	ISO Inferred from Sequence Orthology more info	PubMed
enables poly(A) binding	ISO Inferred from Sequence Orthology more info	PubMed
enables translation repressor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of translation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within negative regulation of translation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of translational initiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: polyadenylate-binding protein-interacting protein 2B

Names: PABP-interacting protein 2B; PAIP-2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.