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Mob1a MOB kinase activator 1A [ Mus musculus (house mouse) ]

Gene ID: 232157, updated on 21-Apr-2024

Summary

Official Symbol
Mob1aprovided by MGI
Official Full Name
MOB kinase activator 1Aprovided by MGI
Primary source
MGI:MGI:2442631
See related
Ensembl:ENSMUSG00000043131 AllianceGenome:MGI:2442631
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MOB1; MOB4B; Mobk1b; Mobkl1b; 4022402H07Rik
Summary
Predicted to enable protein kinase activator activity. Predicted to be involved in hippo signaling and positive regulation of protein phosphorylation. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human MOB1A (MOB kinase activator 1A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 24.7), bladder adult (RPKM 21.4) and 28 other tissues See more
Orthologs
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Genomic context

Location:
6 C3; 6 35.94 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (83303016..83320758)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (83326034..83342812)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 4, sodium bicarbonate cotransporter, member 5 Neighboring gene STARR-seq mESC enhancer starr_16459 Neighboring gene STARR-positive B cell enhancer ABC_E4836 Neighboring gene STARR-positive B cell enhancer ABC_E1323 Neighboring gene STARR-positive B cell enhancer ABC_E6448 Neighboring gene methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase Neighboring gene STARR-seq mESC enhancer starr_16463 Neighboring gene bolA family member 3 Neighboring gene tet methylcytosine dioxygenase 3 Neighboring gene microRNA 6374

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC6884

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in hippo signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
MOB kinase activator 1A
Names
MOB1, Mps One Binder kinase activator-like 1B
mob1 homolog 1B
mps one binder kinase activator-like 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418174.1NP_001405103.1  MOB kinase activator 1A isoform b

    Status: VALIDATED

    Source sequence(s)
    AC159713
  2. NM_001418175.1NP_001405104.1  MOB kinase activator 1A isoform b

    Status: VALIDATED

    Source sequence(s)
    AC159713
  3. NM_001418176.1NP_001405105.1  MOB kinase activator 1A isoform b

    Status: VALIDATED

    Source sequence(s)
    AC159713
  4. NM_001418177.1NP_001405106.1  MOB kinase activator 1A isoform b

    Status: VALIDATED

    Source sequence(s)
    AC159713
  5. NM_001418178.1NP_001405107.1  MOB kinase activator 1A isoform c

    Status: VALIDATED

    Source sequence(s)
    AC159713
    Related
    ENSMUSP00000039115.9, ENSMUST00000038658.15
  6. NM_001418179.1NP_001405108.1  MOB kinase activator 1A isoform d

    Status: VALIDATED

    Source sequence(s)
    AC159713
  7. NM_145571.3NP_663546.1  MOB kinase activator 1A isoform a

    See identical proteins and their annotated locations for NP_663546.1

    Status: VALIDATED

    Source sequence(s)
    AC159713
    Consensus CDS
    CCDS39533.1
    UniProtKB/Swiss-Prot
    Q3TJA6, Q8C194, Q8C1C7, Q921Y0
    UniProtKB/TrEMBL
    Q3UDM0
    Related
    ENSMUSP00000054452.5, ENSMUST00000055261.11
    Conserved Domains (1) summary
    pfam03637
    Location:33204
    Mob1_phocein; Mob1/phocein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    83303016..83320758
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505969.4XP_006506032.1  MOB kinase activator 1A isoform X1

    See identical proteins and their annotated locations for XP_006506032.1

    UniProtKB/TrEMBL
    Q3UDM0
    Conserved Domains (1) summary
    pfam03637
    Location:32203
    Mob1_phocein; Mob1/phocein family