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RRS1 ribosome biogenesis regulator 1 homolog [ Homo sapiens (human) ]

Gene ID: 23212, updated on 5-Aug-2022

Summary

Official Symbol
RRS1provided by HGNC
Official Full Name
ribosome biogenesis regulator 1 homologprovided by HGNC
Primary source
HGNC:HGNC:17083
See related
Ensembl:ENSG00000179041 MIM:618311; AllianceGenome:HGNC:17083
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables 5S rRNA binding activity. Involved in several processes, including mitotic metaphase plate congression; protein localization to nucleolus; and ribosomal large subunit assembly. Located in condensed nuclear chromosome; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See RRS1 in Genome Data Viewer
Location:
8q13.1
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (66429014..66430733)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (66854584..66856303)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (67341249..67342968)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724687 Neighboring gene long intergenic non-protein coding RNA 967 Neighboring gene RRS1 divergent transcript Neighboring gene alcohol dehydrogenase iron containing 1 Neighboring gene TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) (RRS1) at amino acid residues 222-223 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0112

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 5S rRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ribosome biogenesis regulatory protein homolog
Names
RRS1 ribosome biogenesis regulator homolog
homolog of yeast ribosome biogenesis regulator
homolog of yeast ribosome biogenesis regulatory protein RRS1
ribosome biogenesis regulator homolog
ribosome biogenesis regulatory protein RRS1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015169.4NP_055984.1  ribosome biogenesis regulatory protein homolog

    See identical proteins and their annotated locations for NP_055984.1

    Status: VALIDATED

    Source sequence(s)
    AC009879, BC001811, D25218
    Consensus CDS
    CCDS6189.1
    UniProtKB/Swiss-Prot
    Q15050, Q9BUX8
    Related
    ENSP00000322396.2, ENST00000320270.4
    Conserved Domains (1) summary
    pfam04939
    Location:31193
    RRS1; Ribosome biogenesis regulatory protein (RRS1)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    66429014..66430733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    66854584..66856303
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)