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Elmod3 ELMO/CED-12 domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 232089, updated on 1-Mar-2024

Summary

Official Symbol
Elmod3provided by MGI
Official Full Name
ELMO/CED-12 domain containing 3provided by MGI
Primary source
MGI:MGI:2445168
See related
Ensembl:ENSMUSG00000056698 AllianceGenome:MGI:2445168
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RBM29; Rbed1; C330008I15Rik
Summary
Predicted to enable GTPase activator activity. Predicted to be located in cilium; cytoplasm; and cytoskeleton. Predicted to be active in plasma membrane. Is expressed in olfactory epithelium. Used to study autosomal recessive nonsyndromic deafness 88. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 88. Orthologous to human ELMOD3 (ELMO domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 13.1), kidney adult (RPKM 10.7) and 28 other tissues See more
Orthologs
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Genomic context

See Elmod3 in Genome Data Viewer
Location:
6 C1; 6 32.27 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (72542905..72575396, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (72565922..72598431, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene SH2 domain containing 6 Neighboring gene STARR-positive B cell enhancer ABC_E11320 Neighboring gene STARR-seq mESC enhancer starr_16289 Neighboring gene STARR-positive B cell enhancer ABC_E6442 Neighboring gene capping actin protein, gelsolin like Neighboring gene STARR-positive B cell enhancer ABC_E4833 Neighboring gene retinol saturase (all trans retinol 13,14 reductase) Neighboring gene STARR-positive B cell enhancer ABC_E6443 Neighboring gene trans-golgi network protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC27575

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ELMO domain-containing protein 3
Names
RNA binding motif and ELMO domain 1
RNA-binding motif and ELMO domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253692.1NP_001240621.1  ELMO domain-containing protein 3

    See identical proteins and their annotated locations for NP_001240621.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1 and 2 enconde the same protein.
    Source sequence(s)
    AK084010, BE944793, BY074266
    Consensus CDS
    CCDS20243.1
    UniProtKB/Swiss-Prot
    Q3TNV2, Q91YP6
    Related
    ENSMUSP00000067768.2, ENSMUST00000070990.8
    Conserved Domains (1) summary
    pfam04727
    Location:155308
    ELMO_CED12; ELMO/CED-12 family
  2. NM_001364553.1NP_001351482.1  ELMO domain-containing protein 3

    Status: VALIDATED

    Source sequence(s)
    AC125039, AK049155, AK084010, BE944793
    Consensus CDS
    CCDS20243.1
    UniProtKB/Swiss-Prot
    Q3TNV2, Q91YP6
    Conserved Domains (1) summary
    pfam04727
    Location:155308
    ELMO_CED12; ELMO/CED-12 family
  3. NM_001364554.1NP_001351483.1  ELMO domain-containing protein 3

    Status: VALIDATED

    Source sequence(s)
    AK049155, AK084010, BE944793, BU614609
    Consensus CDS
    CCDS20243.1
    UniProtKB/Swiss-Prot
    Q3TNV2, Q91YP6
    Conserved Domains (1) summary
    pfam04727
    Location:155308
    ELMO_CED12; ELMO/CED-12 family
  4. NM_144917.5NP_659166.1  ELMO domain-containing protein 3

    See identical proteins and their annotated locations for NP_659166.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK049155, AK084010, BE944793, BY074266
    Consensus CDS
    CCDS20243.1
    UniProtKB/Swiss-Prot
    Q3TNV2, Q91YP6
    Related
    ENSMUSP00000109703.2, ENSMUST00000114069.8
    Conserved Domains (1) summary
    pfam04727
    Location:155308
    ELMO_CED12; ELMO/CED-12 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    72542905..72575396 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255335.2XP_030111195.1  ELMO domain-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q3TNV2, Q91YP6
    Conserved Domains (1) summary
    pfam04727
    Location:155308
    ELMO_CED12; ELMO/CED-12 family
  2. XM_030255334.2XP_030111194.1  ELMO domain-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q3TNV2, Q91YP6
    Conserved Domains (1) summary
    pfam04727
    Location:155308
    ELMO_CED12; ELMO/CED-12 family
  3. XM_030255333.2XP_030111193.1  ELMO domain-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q3TNV2, Q91YP6
    Conserved Domains (1) summary
    pfam04727
    Location:155308
    ELMO_CED12; ELMO/CED-12 family