Mat2a methionine adenosyltransferase II, alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mat2aprovided by MGI
Official Full Name: methionine adenosyltransferase II, alphaprovided by MGI
Primary source: MGI:MGI:2443731
See related: Ensembl:ENSMUSG00000053907 AllianceGenome:MGI:2443731
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MAT 2; D630045P18Rik
Summary: Enables methionine adenosyltransferase activity. Acts upstream of or within S-adenosylmethionine biosynthetic process and cellular response to leukemia inhibitory factor. Predicted to be part of methionine adenosyltransferase complex. Predicted to be active in cytosol. Is expressed in eye; gut; male reproductive gland or organ; metanephros; and nervous system. Orthologous to human MAT2A (methionine adenosyltransferase 2A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E14 (RPKM 103.5), whole brain E14.5 (RPKM 90.6) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6; 6 C1

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (72409779..72416539, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (72432796..72439556, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dietary folate drives methionine metabolism to promote cancer development by stabilizing MAT IIA.
Title: Dietary folate drives methionine metabolism to promote cancer development by stabilizing MAT IIA.
Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome.
Title: Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome.
Inhibition of MAT2A suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss.
Title: Inhibition of MAT2A suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss.
The reproduction of these changes in MAT1A-KO mice, prone to develop hepatitis and HCC, demonstrates the pathogenetic role of MAT1A gene under-regulation associated with up-regulation of the MAT2A gene (MAT1A:MAT2A switch), encoding the SAM synthesizing enzymes, methyladenosyltransferase I/III (MATI/III) and methyladenosyltransferase II (MATII), respectively. This leads to a rise of MATII, inhibited by the reaction produc
Title: Alterations of Methionine Metabolism as Potential Targets for the Prevention and Therapy of Hepatocellular Carcinoma.
The simultaneous downregulation of MAT1A and upregulation of MAT2A are necessary and sufficient for hepatocellular carcinoma metastasis in the process of M1-M2 switch.
Title: A novel mechanism of the M1-M2 methionine adenosyltransferase switch-mediated hepatocellular carcinoma metastasis.
SIRT1 knock-out embryos display reduced Mat2a expression and histone methylation and are sensitive to maternal methionine restriction-induced lethality, whereas maternal methionine supplementation increases the survival of SIRT1 knock-out newborn mice.
Title: Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development.
P300 acetylates MAT IIalpha at lysine residue 81 and destabilizes MAT IIalpha by promoting its ubiquitylation and subsequent proteasomal degradation.
Title: Acetylation of MAT IIα represses tumour cell growth and is decreased in human hepatocellular cancer.
MATIIalpha represses the expression of cyclooxygenase 2 (COX-2), encoded by Ptgs2, by specifically interacting with histone H3K9 methyltransferase SETDB1.
Title: Methionine adenosyltransferase II-dependent histone H3K9 methylation at the COX-2 gene locus.
Methionine adenosyltransferase II serves as a transcriptional corepressor of Maf oncoprotein
Title: Methionine adenosyltransferase II serves as a transcriptional corepressor of Maf oncoprotein.
MAT2A and MAT2beta genes are induced during hepatic stellate cell activation
Title: Changes in the expression of methionine adenosyltransferase genes and S-adenosylmethionine homeostasis during hepatic stellate cell activation.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from Annotation Pipeline: 298 organisms have orthologs with human gene Mat2a
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables amino acid binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methionine adenosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables methionine adenosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables methionine adenosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables small molecule binding	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in S-adenosylmethionine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within S-adenosylmethionine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in S-adenosylmethionine biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in circadian rhythm	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within one-carbon metabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein heterooligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein hexamerization	ISO Inferred from Sequence Orthology more info
involved_in response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in response to hormone	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of methionine adenosyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of methionine adenosyltransferase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: S-adenosylmethionine synthase isoform type-2

Names: adoMet synthase 2; adoMet synthetase 2; methionine adenosyltransferase 2

NP_001350727.1

EC 2.5.1.6

NP_001350728.1

EC 2.5.1.6

NP_663544.1

EC 2.5.1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001363798.1 → NP_001350727.1 S-adenosylmethionine synthase isoform type-2 isoform 2

Status: VALIDATED

Source sequence(s)

AK160869, BC058360

Consensus CDS

CCDS90059.1

UniProtKB/TrEMBL

A0A0U1RNT6

Related

ENSMUSP00000145696.2, ENSMUST00000205335.2

Conserved Domains (1) summary

cl27369
Location:16 → 362

S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain
NM_001363799.1 → NP_001350728.1 S-adenosylmethionine synthase isoform type-2 isoform 3

Status: VALIDATED

Source sequence(s)

AK133960, BC058360

Consensus CDS

CCDS90060.1

UniProtKB/TrEMBL

A0A0U1RNK6, A0A8C6GMY5

Related

ENSMUSP00000145603.2, ENSMUST00000206692.2

Conserved Domains (1) summary

cl27369
Location:16 → 364

S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain
NM_145569.5 → NP_663544.1 S-adenosylmethionine synthase isoform type-2 isoform 1

See identical proteins and their annotated locations for NP_663544.1

Status: VALIDATED

Source sequence(s)

AC116115

Consensus CDS

CCDS39515.1

UniProtKB/Swiss-Prot

Q3THS6, Q76LX3

UniProtKB/TrEMBL

A0A8C6GPE1, Q99J57

Related

ENSMUSP00000087118.7, ENSMUST00000059472.10

Conserved Domains (1) summary

PTZ00104
Location:16 → 395

PTZ00104; S-adenosylmethionine synthase; Provisional