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SYT11 synaptotagmin 11 [ Homo sapiens (human) ]

Gene ID: 23208, updated on 6-May-2021

Summary

Official Symbol
SYT11provided by HGNC
Official Full Name
synaptotagmin 11provided by HGNC
Primary source
HGNC:HGNC:19239
See related
Ensembl:ENSG00000132718 MIM:608741
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SYT12; sytXI
Summary
This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. The encoded protein is also a substrate for ubiquitin-E3-ligase parkin. The gene has previously been referred to as synaptotagmin XII but has been renamed synaptotagmin XI to be consistent with mouse and rat official nomenclature. [provided by RefSeq, Apr 2010]
Annotation information
Note: In 2002, the HUGO Gene Nomenclature Committee (HGNC) changed the official nomenclature of this locus to be standard with mouse and rat official nomenclature. Therefore, the gene previously known as "synaptotagmin XI" (SYT11, GeneID 23208) became "synaptotagmin XII" (SYT12) and "synaptotagmin XII" (SYT12, GeneID 91683) became "synaptotagmin XI" (SYT11). [13 Feb 2013]
Expression
Biased expression in brain (RPKM 160.9), adrenal (RPKM 11.8) and 1 other tissue See more
Orthologs
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Genomic context

See SYT11 in Genome Data Viewer
Location:
1q22
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (155859502..155885199)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155829358..155854990)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene gon-4 like Neighboring gene small Cajal body-specific RNA 26B Neighboring gene proteasome 26S subunit, non-ATPase 7 pseudogene Neighboring gene Ras like without CAAX 1 Neighboring gene small nucleolar RNA, H/ACA box 80E Neighboring gene KH domain containing 4, pre-mRNA splicing factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.
GeneReviews: Not available
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0080, MGC10881, MGC17226, DKFZp781D015

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables beta-tubulin binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT enables calcium-dependent phospholipid binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables translation initiation factor binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion regulated lysosome exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in calcium-ion regulated exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in establishment of vesicle localization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in learning ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in memory ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of clathrin-coated pit assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of clathrin-dependent endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of dopamine secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of interleukin-6 production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of membrane invagination IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of microglial cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of neurotransmitter secretion TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of synaptic vesicle endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of tumor necrosis factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in plasma membrane repair ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein localization to phagocytic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of dopamine secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of phagosome maturation IC
Inferred by Curator
more info
 
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in clathrin-coated vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in early phagosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in excitatory synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in inhibitory synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in integral component of presynaptic active zone membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in phagocytic cup IEA
Inferred from Electronic Annotation
more info
 
located_in phagocytic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in presynapse ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in presynaptic active zone membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in recycling endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT located_in synaptic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in synaptic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in synaptic vesicle TAS
Traceable Author Statement
more info
PubMed 
located_in terminal bouton IEA
Inferred from Electronic Annotation
more info
 
located_in trans-Golgi network ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
synaptotagmin-11
Names
synaptotagmin 12
synaptotagmin XI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152280.5NP_689493.3  synaptotagmin-11

    See identical proteins and their annotated locations for NP_689493.3

    Status: REVIEWED

    Source sequence(s)
    AA824539, AL139128, BC004291, DA239014
    Consensus CDS
    CCDS1122.1
    UniProtKB/Swiss-Prot
    Q9BT88
    Related
    ENSP00000357307.4, ENST00000368324.5
    Conserved Domains (2) summary
    cd08388
    Location:158283
    C2A_Synaptotagmin-4-11; C2A domain first repeat present in Synaptotagmins 4 and 11
    cd08404
    Location:292429
    C2B_Synaptotagmin-4; C2 domain second repeat present in Synaptotagmin 4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    155859502..155885199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000759.2XP_016856248.1  synaptotagmin-11 isoform X1

  2. XM_005245014.3XP_005245071.1  synaptotagmin-11 isoform X2

    Conserved Domains (2) summary
    cd08388
    Location:158283
    C2A_Synaptotagmin-4-11; C2A domain first repeat present in Synaptotagmins 4 and 11
    cd08404
    Location:292428
    C2B_Synaptotagmin-4; C2 domain second repeat present in Synaptotagmin 4
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