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ATP11B ATPase phospholipid transporting 11B (putative) [ Homo sapiens (human) ]

Gene ID: 23200, updated on 17-Jun-2019

Summary

Official Symbol
ATP11Bprovided by HGNC
Official Full Name
ATPase phospholipid transporting 11B (putative)provided by HGNC
Primary source
HGNC:HGNC:13553
See related
Ensembl:ENSG00000058063 MIM:605869
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATPIF; ATPIR
Summary
P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily transports heavy metal ions, such as Cu(2+) or Cd(2+). Another subfamily transports non-heavy metal ions, such as H(+), Na(+), K(+), or Ca(+). A third subfamily transports amphipaths, such as phosphatidylserine.[supplied by OMIM, Feb 2005]
Expression
Ubiquitous expression in esophagus (RPKM 12.0), bone marrow (RPKM 11.3) and 25 other tissues See more
Orthologs

Genomic context

See ATP11B in Genome Data Viewer
Location:
3q26.33
Exon count:
34
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (182793504..182923010)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (182511291..182639423)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986054 Neighboring gene uncharacterized LOC105374245 Neighboring gene eukaryotic translation initiation factor 3 subunit E pseudogene 4 Neighboring gene chromosome 9 open reading frame 85 pseudogene Neighboring gene defective in cullin neddylation 1 domain containing 1 Neighboring gene uncharacterized LOC105374246

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Ion channel transport, organism-specific biosystem (from REACTOME)
    Ion channel transport, organism-specific biosystemIon channels mediate the flow of ions across the plasma membrane of cells. They are integral membrane proteins, typically a multimer of proteins, which, when arranged in the membrane, create a pore f...
  • Ion transport by P-type ATPases, organism-specific biosystem (from REACTOME)
    Ion transport by P-type ATPases, organism-specific biosystemThe P-type ATPases (E1-E2 ATPases) are a large group of evolutionarily related ion pumps that are found in bacteria, archaea and eukaryotes. They are referred to as P-type ATPases because they catal...
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0956, MGC46576, DKFZp434J238, DKFZp434N1615

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ion transmembrane transporter activity NAS
Non-traceable Author Statement
more info
PubMed 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
aminophospholipid transport TAS
Traceable Author Statement
more info
PubMed 
ion transmembrane transport TAS
Traceable Author Statement
more info
 
ion transport NAS
Non-traceable Author Statement
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid translocation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
azurophil granule membrane TAS
Traceable Author Statement
more info
 
early endosome IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
nuclear inner membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
 
trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
probable phospholipid-transporting ATPase IF
Names
ATPase IR
ATPase, class VI, type 11B
P4-ATPase flippase complex alpha subunit ATP11B
truncated ATPase 11B protein
NP_055431.1
XP_005247298.1
XP_005247300.1
XP_011510895.1
XP_011510896.1
XP_011510899.1
XP_016861497.1
XP_016861498.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014616.3NP_055431.1  probable phospholipid-transporting ATPase IF

    See identical proteins and their annotated locations for NP_055431.1

    Status: VALIDATED

    Source sequence(s)
    AB023173, AF156548, AK296750, AK304855, AL133061, BI861412, BX489704, DR000074
    Consensus CDS
    CCDS33896.1
    UniProtKB/Swiss-Prot
    Q9Y2G3
    UniProtKB/TrEMBL
    B4DKX1, B4E3T1
    Related
    ENSP00000321195.5, ENST00000323116.10
    Conserved Domains (6) summary
    TIGR01652
    Location:391106
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:96180
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:494605
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:3589
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:8471100
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:629868
    HAD_like; Haloacid Dehalogenase-like Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    182793504..182923010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512593.2XP_011510895.1  probable phospholipid-transporting ATPase IF isoform X2

    Conserved Domains (6) summary
    TIGR01652
    Location:391106
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:96180
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:494605
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:3589
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:8471100
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:629868
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  2. XM_005247241.2XP_005247298.1  probable phospholipid-transporting ATPase IF isoform X1

    Conserved Domains (6) summary
    TIGR01652
    Location:391106
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:96180
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:494605
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:3589
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:8471100
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:629868
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  3. XM_011512594.2XP_011510896.1  probable phospholipid-transporting ATPase IF isoform X3

    Conserved Domains (6) summary
    TIGR01652
    Location:391106
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:96180
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:494605
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:3589
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:8471100
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:629868
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  4. XM_017006009.1XP_016861498.1  probable phospholipid-transporting ATPase IF isoform X7

  5. XM_005247243.2XP_005247300.1  probable phospholipid-transporting ATPase IF isoform X4

    Conserved Domains (3) summary
    pfam13246
    Location:312423
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16212
    Location:665918
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:447686
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  6. XM_017006008.1XP_016861497.1  probable phospholipid-transporting ATPase IF isoform X6

    Conserved Domains (3) summary
    pfam13246
    Location:175286
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16212
    Location:528781
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:310549
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  7. XM_011512597.2XP_011510899.1  probable phospholipid-transporting ATPase IF isoform X5

    Related
    ENSP00000418421.1, ENST00000498086.5
    Conserved Domains (3) summary
    pfam13246
    Location:274385
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16212
    Location:627880
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:409648
    HAD_like; Haloacid Dehalogenase-like Hydrolases

RNA

  1. XR_001740066.1 RNA Sequence

  2. XR_001740067.1 RNA Sequence

  3. XR_001740068.1 RNA Sequence

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