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Jazf1 JAZF zinc finger 1 [ Mus musculus (house mouse) ]

Gene ID: 231986, updated on 13-Dec-2022

Summary

Official Symbol
Jazf1provided by MGI
Official Full Name
JAZF zinc finger 1provided by MGI
Primary source
MGI:MGI:2141450
See related
Ensembl:ENSMUSG00000063568 AllianceGenome:MGI:2141450
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Jaz1; Tip27; C820002C15
Summary
Predicted to enable transcription corepressor activity. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Is expressed in several structures, including gut; nervous system; reproductive system; respiratory system; and sensory organ. Orthologous to human JAZF1 (JAZF zinc finger 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 14.8), CNS E18 (RPKM 12.6) and 13 other tissues See more
Orthologs
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Genomic context

See Jazf1 in Genome Data Viewer
Location:
6 B3; 6 25.74 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (52745050..53045615, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (52768065..53068624, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L24 pseudogene Neighboring gene Tax1 (human T cell leukemia virus type I) binding protein 1 Neighboring gene predicted gene, 52904 Neighboring gene predicted gene, 52903 Neighboring gene predicted gene, 33219 Neighboring gene dynactin subunit 5 pseudogene Neighboring gene predicted gene, 33097 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene quinolinate phosphoribosyltransferase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of transcription repressor complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
juxtaposed with another zinc finger protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168277.2NP_001161749.1  juxtaposed with another zinc finger protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001161749.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC107317, AC117212
    UniProtKB/Swiss-Prot
    Q80ZQ5
    Conserved Domains (1) summary
    COG5189
    Location:105166
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
  2. NM_001411537.1NP_001398466.1  juxtaposed with another zinc finger protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC084326, AC107317, AC117212
  3. NM_173406.4NP_775582.2  juxtaposed with another zinc finger protein 1 isoform 1

    See identical proteins and their annotated locations for NP_775582.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC084326, AC107317, AC117212
    Consensus CDS
    CCDS20152.1
    UniProtKB/Swiss-Prot
    Q80ZQ5, Q8BWN4
    UniProtKB/TrEMBL
    A0A6P5PWA3, A0A8C6GUR9
    Related
    ENSMUSP00000074129.6, ENSMUST00000074541.6
    Conserved Domains (1) summary
    COG5189
    Location:169230
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    52745050..53045615 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505943.5XP_006506006.1  juxtaposed with another zinc finger protein 1 isoform X1

    Conserved Domains (1) summary
    COG5189
    Location:142203
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
  2. XM_011241295.2XP_011239597.1  juxtaposed with another zinc finger protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011239597.1

    UniProtKB/Swiss-Prot
    Q80ZQ5
    Conserved Domains (1) summary
    COG5189
    Location:105166
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
  3. XM_036166037.1XP_036021930.1  juxtaposed with another zinc finger protein 1 isoform X2

    Conserved Domains (1) summary
    COG5189
    Location:105166
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
  4. XM_036166036.1XP_036021929.1  juxtaposed with another zinc finger protein 1 isoform X2

    Conserved Domains (1) summary
    COG5189
    Location:105166
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]