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PSME4 proteasome activator subunit 4 [ Homo sapiens (human) ]

Gene ID: 23198, updated on 6-Sep-2021

Summary

Official Symbol
PSME4provided by HGNC
Official Full Name
proteasome activator subunit 4provided by HGNC
Primary source
HGNC:HGNC:20635
See related
Ensembl:ENSG00000068878 MIM:607705
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PA200
Expression
Broad expression in testis (RPKM 32.8), endometrium (RPKM 14.4) and 24 other tissues See more
Orthologs
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Genomic context

See PSME4 in Genome Data Viewer
Location:
2p16.2
Exon count:
47
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (53864069..53970993, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (54091206..54198130, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene GPR75-ASB3 readthrough Neighboring gene microRNA 3682 Neighboring gene G protein-coupled receptor 75 Neighboring gene Sharpr-MPRA regulatory region 11857 Neighboring gene acylphosphatase 2 Neighboring gene ribosomal protein L21 pseudogene 30 Neighboring gene high mobility group box 1 pseudogene 31

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat slightly enhances the activity of the purified 26 S proteasome PubMed
tat Amino acids Lys51, Arg52, and Asp67 of HIV-1 Tat represent the proteasome binding site of Tat, and Tat amino acids 37-72 are necessary for proteasomal interaction and suppression of 11 S regulator-mediated antigen presentation PubMed
tat HIV-1 Tat inhibits the peptidase activity of the 20 S proteasome and interferes with the formation of the 20 S proteasome-11 S regulator complex PubMed
tat HIV-1 Tat binds to the alpha2, alpha4, alpha6, alpha7, beta1, beta2, beta3, beta5, beta6, beta7, LMP7/beta5i, and MECL1/beta2i subunits of the proteasome 20 S core structure and can inhibit cellular proteasome function PubMed
Vif vif HIV-1 Vif binds to the cellular cytidine deaminase APOBEC3G and targets it for degradation through an interaction with the proteasome, thereby inhibiting APOBEC3G mediated restriction of HIV-1 replication PubMed
integrase gag-pol Proteasomal degradation of HIV-1 integrase in mammalian cells occurs by the N-end rule pathway PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21864, KIAA0077, MGC138374, MGC142228

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lysine-acetylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lysine-acetylated histone binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables peptidase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptidase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables proteasome binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to DNA damage stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in proteasomal ubiquitin-independent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteasomal ubiquitin-independent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in spermatogenesis, exchange of chromosomal proteins IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in spermatogenesis, exchange of chromosomal proteins ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of spermatoproteasome complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of spermatoproteasome complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
proteasome activator complex subunit 4
Names
proteasome (prosome, macropain) activator subunit 4
proteasome activator 200 kDa
proteasome activator PA200

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014614.3NP_055429.2  proteasome activator complex subunit 4

    See identical proteins and their annotated locations for NP_055429.2

    Status: VALIDATED

    Source sequence(s)
    AA884260, AC008068, AL045471, AY894754, BC113668
    Consensus CDS
    CCDS33197.2
    UniProtKB/Swiss-Prot
    Q14997
    Related
    ENSP00000384211.1, ENST00000404125.6
    Conserved Domains (3) summary
    sd00044
    Location:16421671
    HEAT; HEAT repeat [structural motif]
    pfam11919
    Location:17571842
    DUF3437; Domain of unknown function (DUF3437)
    pfam16507
    Location:330828
    BLM10_mid; Proteasome-substrate-size regulator, mid region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    53864069..53970993 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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