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PSME4 proteasome activator subunit 4 [ Homo sapiens (human) ]

Gene ID: 23198, updated on 24-Nov-2020

Summary

Official Symbol
PSME4provided by HGNC
Official Full Name
proteasome activator subunit 4provided by HGNC
Primary source
HGNC:HGNC:20635
See related
Ensembl:ENSG00000068878 MIM:607705
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PA200
Expression
Broad expression in testis (RPKM 32.8), endometrium (RPKM 14.4) and 24 other tissues See more
Orthologs

Genomic context

See PSME4 in Genome Data Viewer
Location:
2p16.2
Exon count:
49
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (53864069..53970993, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (54091204..54197977, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene GPR75-ASB3 readthrough Neighboring gene microRNA 3682 Neighboring gene G protein-coupled receptor 75 Neighboring gene acylphosphatase 2 Neighboring gene ribosomal protein L21 pseudogene 30 Neighboring gene high mobility group box 1 pseudogene 31

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat slightly enhances the activity of the purified 26 S proteasome PubMed
tat Amino acids Lys51, Arg52, and Asp67 of HIV-1 Tat represent the proteasome binding site of Tat, and Tat amino acids 37-72 are necessary for proteasomal interaction and suppression of 11 S regulator-mediated antigen presentation PubMed
tat HIV-1 Tat inhibits the peptidase activity of the 20 S proteasome and interferes with the formation of the 20 S proteasome-11 S regulator complex PubMed
tat HIV-1 Tat binds to the alpha2, alpha4, alpha6, alpha7, beta1, beta2, beta3, beta5, beta6, beta7, LMP7/beta5i, and MECL1/beta2i subunits of the proteasome 20 S core structure and can inhibit cellular proteasome function PubMed
Vif vif HIV-1 Vif binds to the cellular cytidine deaminase APOBEC3G and targets it for degradation through an interaction with the proteasome, thereby inhibiting APOBEC3G mediated restriction of HIV-1 replication PubMed
integrase gag-pol Proteasomal degradation of HIV-1 integrase in mammalian cells occurs by the N-end rule pathway PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21864, KIAA0077, MGC138374, MGC142228

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lysine-acetylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysine-acetylated histone binding ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
proteasome binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
 
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
MAPK cascade TAS
Traceable Author Statement
more info
 
NIK/NF-kappaB signaling TAS
Traceable Author Statement
more info
 
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 
T cell receptor signaling pathway TAS
Traceable Author Statement
more info
 
Wnt signaling pathway, planar cell polarity pathway TAS
Traceable Author Statement
more info
 
anaphase-promoting complex-dependent catabolic process TAS
Traceable Author Statement
more info
 
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
Traceable Author Statement
more info
 
cellular response to DNA damage stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
interleukin-1-mediated signaling pathway TAS
Traceable Author Statement
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
negative regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
proteasomal ubiquitin-independent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasomal ubiquitin-independent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 
protein deubiquitination TAS
Traceable Author Statement
more info
 
protein polyubiquitination TAS
Traceable Author Statement
more info
 
regulation of cellular amino acid metabolic process TAS
Traceable Author Statement
more info
 
regulation of hematopoietic stem cell differentiation TAS
Traceable Author Statement
more info
 
regulation of mRNA stability TAS
Traceable Author Statement
more info
 
regulation of mitotic cell cycle phase transition TAS
Traceable Author Statement
more info
 
regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
Traceable Author Statement
more info
 
spermatogenesis, exchange of chromosomal proteins IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spermatogenesis, exchange of chromosomal proteins ISS
Inferred from Sequence or Structural Similarity
more info
 
stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
 
transmembrane transport TAS
Traceable Author Statement
more info
 
tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
spermatoproteasome complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spermatoproteasome complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
proteasome activator complex subunit 4
Names
proteasome (prosome, macropain) activator subunit 4
proteasome activator 200 kDa
proteasome activator PA200

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014614.3NP_055429.2  proteasome activator complex subunit 4

    See identical proteins and their annotated locations for NP_055429.2

    Status: VALIDATED

    Source sequence(s)
    AA884260, AC008068, AL045471, AY894754, BC113668
    Consensus CDS
    CCDS33197.2
    UniProtKB/Swiss-Prot
    Q14997
    Related
    ENSP00000384211.1, ENST00000404125.6
    Conserved Domains (3) summary
    sd00044
    Location:16421671
    HEAT; HEAT repeat [structural motif]
    pfam11919
    Location:17571842
    DUF3437; Domain of unknown function (DUF3437)
    pfam16507
    Location:330828
    BLM10_mid; Proteasome-substrate-size regulator, mid region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    53864069..53970993 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532707.2XP_011531009.1  proteasome activator complex subunit 4 isoform X3

    Conserved Domains (3) summary
    pfam11919
    Location:17611846
    DUF3437; Domain of unknown function (DUF3437)
    pfam16507
    Location:330828
    BLM10_mid; Proteasome-substrate-size regulator, mid region
    sd00044
    Location:16421671
    HEAT; HEAT repeat [structural motif]
  2. XM_011532706.2XP_011531008.1  proteasome activator complex subunit 4 isoform X2

    Conserved Domains (3) summary
    pfam11919
    Location:17791864
    DUF3437; Domain of unknown function (DUF3437)
    pfam16507
    Location:352850
    BLM10_mid; Proteasome-substrate-size regulator, mid region
    sd00044
    Location:16641693
    HEAT; HEAT repeat [structural motif]
  3. XM_011532705.2XP_011531007.1  proteasome activator complex subunit 4 isoform X1

    Conserved Domains (3) summary
    pfam11919
    Location:17831868
    DUF3437; Domain of unknown function (DUF3437)
    pfam16507
    Location:352850
    BLM10_mid; Proteasome-substrate-size regulator, mid region
    sd00044
    Location:16641693
    HEAT; HEAT repeat [structural motif]
  4. XM_006711969.1XP_006712032.1  proteasome activator complex subunit 4 isoform X5

    Conserved Domains (2) summary
    pfam11919
    Location:9151000
    DUF3437; Domain of unknown function (DUF3437)
    sd00044
    Location:800829
    HEAT; HEAT repeat [structural motif]
  5. XM_011532709.2XP_011531011.1  proteasome activator complex subunit 4 isoform X4

    Conserved Domains (1) summary
    pfam16507
    Location:352850
    BLM10_mid; Proteasome-substrate-size regulator, mid region

RNA

  1. XR_001738679.1 RNA Sequence

    Related
    ENST00000389993.7
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