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MDN1 midasin AAA ATPase 1 [ Homo sapiens (human) ]

Gene ID: 23195, updated on 7-Jun-2020

Summary

Official Symbol
MDN1provided by HGNC
Official Full Name
midasin AAA ATPase 1provided by HGNC
Primary source
HGNC:HGNC:18302
See related
Ensembl:ENSG00000112159 MIM:618200
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Rea1
Expression
Ubiquitous expression in ovary (RPKM 5.6), testis (RPKM 4.9) and 25 other tissues See more
Orthologs

Genomic context

See MDN1 in Genome Data Viewer
Location:
6q15
Exon count:
105
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (89642498..89828021, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (90352494..90529442, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 6 Neighboring gene uncharacterized LOC105377887 Neighboring gene uncharacterized LOC101929057 Neighboring gene LYR motif containing 2 Neighboring gene DnaJ heat shock protein family (Hsp40) member C19 pseudogene 6 Neighboring gene PIMREG pseudogene 3 Neighboring gene caspase 8 associated protein 2 Neighboring gene ribosomal protein L22 pseudogene 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of MDN1, midasin homolog by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23395, FLJ25587, FLJ42031, FLJ43191, KIAA0301, DKFZp686H16106

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
unfolded protein binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
protein-containing complex assembly NAS
Non-traceable Author Statement
more info
PubMed 
rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribosomal large subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
midasin
Names
MDN1, midasin homolog
MIDAS-containing protein
dynein-related AAA-ATPase MDN1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034012.1 RefSeqGene

    Range
    5001..182297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014611.3NP_055426.1  midasin

    See identical proteins and their annotated locations for NP_055426.1

    Status: VALIDATED

    Source sequence(s)
    AF503925, AK027048, AL096678, BC036888, BP360573
    Consensus CDS
    CCDS5024.1
    UniProtKB/Swiss-Prot
    Q9NU22
    Related
    ENSP00000358400.3, ENST00000369393.8
    Conserved Domains (7) summary
    cd00009
    Location:659780
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    smart00382
    Location:13831540
    AAA; ATPases associated with a variety of cellular activities
    COG0714
    Location:17361923
    MoxR; MoxR-like ATPase [General function prediction only]
    cd01460
    Location:53235593
    vWA_midasin; VWA_Midasin: Midasin is a member of the AAA ATPase family. The proteins of this family are unified by their common archetectural organization that is based upon a conserved ATPase domain. The AAA domain of midasin contains six tandem AAA protomers. The ...
    pfam03247
    Location:49125020
    Prothymosin; Prothymosin/parathymosin family
    pfam07728
    Location:13851540
    AAA_5; AAA domain (dynein-related subfamily)
    cl21455
    Location:10791215
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    89642498..89828021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535635.2XP_011533937.1  midasin isoform X1

    Conserved Domains (7) summary
    cd00009
    Location:562683
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    smart00382
    Location:12861443
    AAA; ATPases associated with a variety of cellular activities
    COG0714
    Location:16391826
    MoxR; MoxR-like ATPase [General function prediction only]
    cd01460
    Location:52265496
    vWA_midasin; VWA_Midasin: Midasin is a member of the AAA ATPase family. The proteins of this family are unified by their common archetectural organization that is based upon a conserved ATPase domain. The AAA domain of midasin contains six tandem AAA protomers. The ...
    pfam03247
    Location:48154923
    Prothymosin; Prothymosin/parathymosin family
    pfam07728
    Location:12881443
    AAA_5; AAA domain (dynein-related subfamily)
    cl21455
    Location:9821118
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_006715405.3XP_006715468.1  midasin isoform X4

    Conserved Domains (3) summary
    cd01460
    Location:34713741
    vWA_midasin; VWA_Midasin: Midasin is a member of the AAA ATPase family. The proteins of this family are unified by their common archetectural organization that is based upon a conserved ATPase domain. The AAA domain of midasin contains six tandem AAA protomers. The ...
    cl00909
    Location:30613128
    Ribosomal_L24e_L24; Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor ...
    cl21455
    Location:368454
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_005248700.3XP_005248757.1  midasin isoform X5

    Conserved Domains (3) summary
    cd01460
    Location:33183588
    vWA_midasin; VWA_Midasin: Midasin is a member of the AAA ATPase family. The proteins of this family are unified by their common archetectural organization that is based upon a conserved ATPase domain. The AAA domain of midasin contains six tandem AAA protomers. The ...
    cl00909
    Location:29082975
    Ribosomal_L24e_L24; Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor ...
    cl21455
    Location:215301
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. XM_011535636.3XP_011533938.1  midasin isoform X2

    Conserved Domains (6) summary
    cd00009
    Location:659780
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    smart00382
    Location:13831540
    AAA; ATPases associated with a variety of cellular activities
    COG0714
    Location:17361923
    MoxR; MoxR-like ATPase [General function prediction only]
    pfam03247
    Location:49125020
    Prothymosin; Prothymosin/parathymosin family
    pfam07728
    Location:13851540
    AAA_5; AAA domain (dynein-related subfamily)
    cl21455
    Location:10791215
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  5. XM_024446382.1XP_024302150.1  midasin isoform X3

    Conserved Domains (1) summary
    cl26761
    Location:2062313
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_017363815.1 Reference GRCh38.p13 PATCHES

    Range
    14838..15139 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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