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MDN1 midasin AAA ATPase 1 [ Homo sapiens (human) ]

Gene ID: 23195, updated on 5-Feb-2023

Summary

Official Symbol
MDN1provided by HGNC
Official Full Name
midasin AAA ATPase 1provided by HGNC
Primary source
HGNC:HGNC:18302
See related
Ensembl:ENSG00000112159 MIM:618200; AllianceGenome:HGNC:18302
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Rea1
Summary
Predicted to enable ATP binding activity. Involved in ribosomal large subunit assembly. Located in cytosol; intermediate filament cytoskeleton; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 5.6), testis (RPKM 4.9) and 25 other tissues See more
Orthologs
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Genomic context

See MDN1 in Genome Data Viewer
Location:
6q15
Exon count:
102
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (89642498..89819794, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (90851868..91029153, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (90352217..90529513, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 6 Neighboring gene uncharacterized LOC124901359 Neighboring gene MDN1 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 852 Neighboring gene LYR motif containing 2 Neighboring gene DnaJ heat shock protein family (Hsp40) member C19 pseudogene 6 Neighboring gene small nucleolar RNA U13 Neighboring gene PIMREG pseudogene 3 Neighboring gene caspase 8 associated protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of MDN1, midasin homolog by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23395, FLJ25587, FLJ42031, FLJ43191, KIAA0301, DKFZp686H16106

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ribosomal large subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ribosomal large subunit assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ribosomal large subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
 
located_in membrane HDA PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
midasin
Names
MDN1, midasin homolog
MIDAS-containing protein
dynein-related AAA-ATPase MDN1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034012.1 RefSeqGene

    Range
    5001..182297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014611.3NP_055426.1  midasin

    See identical proteins and their annotated locations for NP_055426.1

    Status: VALIDATED

    Source sequence(s)
    AF503925, AK027048, AL096678, BC036888, BP360573
    Consensus CDS
    CCDS5024.1
    UniProtKB/Swiss-Prot
    Q5T794, Q9NU22
    Related
    ENSP00000358400.3, ENST00000369393.8
    Conserved Domains (7) summary
    cd00009
    Location:659780
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    smart00382
    Location:13831540
    AAA; ATPases associated with a variety of cellular activities
    COG0714
    Location:17361923
    MoxR; MoxR-like ATPase [General function prediction only]
    cd01460
    Location:53235593
    vWA_midasin; VWA_Midasin: Midasin is a member of the AAA ATPase family. The proteins of this family are unified by their common archetectural organization that is based upon a conserved ATPase domain. The AAA domain of midasin contains six tandem AAA protomers. The ...
    pfam03247
    Location:49125020
    Prothymosin; Prothymosin/parathymosin family
    pfam07728
    Location:13851540
    AAA_5; AAA domain (dynein-related subfamily)
    cl21455
    Location:10791215
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    89642498..89819794 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_017363815.1 Reference GRCh38.p14 PATCHES

    Range
    14838..15139 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    90851868..91029153 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)