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Daglb diacylglycerol lipase, beta [ Mus musculus (house mouse) ]

Gene ID: 231871, updated on 5-Jan-2023

Summary

Official Symbol
Daglbprovided by MGI
Official Full Name
diacylglycerol lipase, betaprovided by MGI
Primary source
MGI:MGI:2442032
See related
Ensembl:ENSMUSG00000039206 AllianceGenome:MGI:2442032
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E330036I19Rik
Summary
Enables triglyceride lipase activity. Involved in positive regulation of triglyceride catabolic process; regulation of inflammatory response; and unsaturated fatty acid metabolic process. Acts upstream of or within neuroblast proliferation and neurotransmitter biosynthetic process. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in postsynaptic membrane. Is expressed in brain; liver; and spinal cord. Orthologous to human DAGLB (diacylglycerol lipase beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 20.1), mammary gland adult (RPKM 16.6) and 27 other tissues See more
Orthologs
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Genomic context

See Daglb in Genome Data Viewer
Location:
5; 5 G2
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (143450239..143490197)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (143464484..143504442)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene cyclin B1 pseudogene Neighboring gene predicted gene 9497 Neighboring gene Rac family small GTPase 1 Neighboring gene family with sequence similarity 220, member A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC27690

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables lipase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables lipase activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables triglyceride lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables triglyceride lipase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in arachidonic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in arachidonic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within arachidonic acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in arachidonic acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in arachidonic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in diacylglycerol catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in icosanoid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neurotransmitter biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within neurotransmitter biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of triglyceride catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in prostaglandin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
diacylglycerol lipase-beta
Names
DAGL-beta
DAGLbeta
DGL-beta
PUFA-specific triacylglycerol lipase
sn1-specific diacylglycerol lipase beta
NP_659164.2
XP_006504761.1
XP_006504763.1
XP_030110321.1
XP_036020998.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144915.3NP_659164.2  diacylglycerol lipase-beta

    See identical proteins and their annotated locations for NP_659164.2

    Status: VALIDATED

    Source sequence(s)
    AK136372, BE992098, BY314231, CO043884
    Consensus CDS
    CCDS39370.1
    UniProtKB/Swiss-Prot
    Q8BV05, Q91WC9
    Related
    ENSMUSP00000043088.9, ENSMUST00000045593.12
    Conserved Domains (1) summary
    cd00519
    Location:274507
    Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    143450239..143490197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254461.2XP_030110321.1  diacylglycerol lipase-beta isoform X3

    Conserved Domains (1) summary
    cd00519
    Location:127360
    Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...
  2. XM_006504698.4XP_006504761.1  diacylglycerol lipase-beta isoform X2

    Conserved Domains (1) summary
    cd00519
    Location:147380
    Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...
  3. XM_006504700.3XP_006504763.1  diacylglycerol lipase-beta isoform X4

    Conserved Domains (1) summary
    cd00519
    Location:1226
    Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...
  4. XM_036165105.1XP_036020998.1  diacylglycerol lipase-beta isoform X1

    Conserved Domains (1) summary
    cl21494
    Location:274479
    Abhydrolase; alpha/beta hydrolases