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Radil Ras association and DIL domains [ Mus musculus (house mouse) ]

Gene ID: 231858, updated on 30-Apr-2024

Summary

Official Symbol
Radilprovided by MGI
Official Full Name
Ras association and DIL domainsprovided by MGI
Primary source
MGI:MGI:2443088
See related
Ensembl:ENSMUSG00000029576 AllianceGenome:MGI:2443088
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D930005D10Rik
Summary
Predicted to enable GTPase binding activity. Predicted to be involved in neural crest cell migration and substrate adhesion-dependent cell spreading. Predicted to act upstream of or within cell adhesion. Predicted to be part of protein-containing complex. Predicted to be active in microtubule. Is expressed in testis. Orthologous to human RADIL (Rap associating with DIL domain). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 12.8), lung adult (RPKM 12.5) and 16 other tissues See more
Orthologs
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Genomic context

See Radil in Genome Data Viewer
Location:
5 G2; 5 81.53 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (142470594..142536873, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (142483795..142551098, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene forkhead box K1 Neighboring gene predicted gene, 54310 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:142915875-142916058 Neighboring gene STARR-positive B cell enhancer ABC_E4804 Neighboring gene STARR-positive B cell enhancer ABC_E2771 Neighboring gene STARR-seq mESC enhancer starr_14747 Neighboring gene adaptor-related protein complex 5, zeta 1 subunit Neighboring gene predicted gene, 38732 Neighboring gene poly (A) polymerase beta (testis specific) Neighboring gene STARR-positive B cell enhancer ABC_E8090 Neighboring gene monocyte to macrophage differentiation-associated 2 Neighboring gene predicted gene, 31274

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in neural crest cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in substrate adhesion-dependent cell spreading IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ras-associating and dilute domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289588.1NP_001276517.1  ras-associating and dilute domain-containing protein isoform 1

    See identical proteins and their annotated locations for NP_001276517.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AI536456, AK162917, BY201066
    Consensus CDS
    CCDS71698.1
    UniProtKB/TrEMBL
    D3YWJ9
    Related
    ENSMUSP00000106412.2, ENSMUST00000110785.2
    Conserved Domains (4) summary
    cd00992
    Location:9921076
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15472
    Location:411778
    Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
    cd17116
    Location:50161
    RA_Radil_like; Ras-associating (RA) domain found in ras-associating and dilute domain-containing protein (Radil) and similar proteins
    pfam00498
    Location:273343
    FHA; FHA domain
  2. NM_001310752.1NP_001297681.1  ras-associating and dilute domain-containing protein isoform 3

    See identical proteins and their annotated locations for NP_001297681.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AI536456, AK052964, AK083410
    Consensus CDS
    CCDS80453.1
    UniProtKB/Swiss-Prot
    Q69Z89, Q8BNL0, Q8C549, Q8C6X2, Q8CAL1
    Related
    ENSMUSP00000082910.4, ENSMUST00000085758.10
    Conserved Domains (4) summary
    cd00992
    Location:9981082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15472
    Location:440807
    Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
    pfam00498
    Location:302372
    FHA; FHA domain
    pfam00788
    Location:90193
    RA; Ras association (RalGDS/AF-6) domain
  3. NM_178702.4NP_848817.2  ras-associating and dilute domain-containing protein isoform 2

    See identical proteins and their annotated locations for NP_848817.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site inthe 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AI536456, BC056483, BY201066
    Consensus CDS
    CCDS19827.1
    UniProtKB/Swiss-Prot
    Q69Z89
    Related
    ENSMUSP00000064539.9, ENSMUST00000063635.15
    Conserved Domains (4) summary
    cd00992
    Location:9691053
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15472
    Location:411778
    Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
    pfam00498
    Location:273343
    FHA; FHA domain
    pfam00788
    Location:61164
    RA; Ras association (RalGDS/AF-6) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    142470594..142536873 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504685.5XP_006504748.1  ras-associating and dilute domain-containing protein isoform X2

    See identical proteins and their annotated locations for XP_006504748.1

    UniProtKB/TrEMBL
    D3YWJ9
    Conserved Domains (4) summary
    cd00992
    Location:9921076
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15472
    Location:411778
    Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
    cd17116
    Location:50161
    RA_Radil_like; Ras-associating (RA) domain found in ras-associating and dilute domain-containing protein (Radil) and similar proteins
    pfam00498
    Location:273343
    FHA; FHA domain
  2. XM_006504682.4XP_006504745.1  ras-associating and dilute domain-containing protein isoform X1

    Conserved Domains (4) summary
    cd00992
    Location:10211105
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15472
    Location:440807
    Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
    cd17116
    Location:79190
    RA_Radil_like; Ras-associating (RA) domain found in ras-associating and dilute domain-containing protein (Radil) and similar proteins
    pfam00498
    Location:302372
    FHA; FHA domain
  3. XM_030254449.2XP_030110309.1  ras-associating and dilute domain-containing protein isoform X5

    Conserved Domains (2) summary
    cd00992
    Location:475559
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15472
    Location:1284
    Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
  4. XM_030254445.2XP_030110305.1  ras-associating and dilute domain-containing protein isoform X3

    Conserved Domains (3) summary
    cd00992
    Location:752836
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15472
    Location:171538
    Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
    pfam00498
    Location:33103
    FHA; FHA domain
  5. XM_030254446.2XP_030110306.1  ras-associating and dilute domain-containing protein isoform X3

    Conserved Domains (3) summary
    cd00992
    Location:752836
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15472
    Location:171538
    Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
    pfam00498
    Location:33103
    FHA; FHA domain
  6. XM_006504686.4XP_006504749.1  ras-associating and dilute domain-containing protein isoform X4

    See identical proteins and their annotated locations for XP_006504749.1

    UniProtKB/Swiss-Prot
    Q69Z89
    Related
    ENSMUSP00000106411.2, ENSMUST00000110784.8
    Conserved Domains (3) summary
    cd00992
    Location:729813
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15472
    Location:171538
    Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
    pfam00498
    Location:33103
    FHA; FHA domain
  7. XM_030254447.2XP_030110307.1  ras-associating and dilute domain-containing protein isoform X4

    Conserved Domains (3) summary
    cd00992
    Location:729813
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15472
    Location:171538
    Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
    pfam00498
    Location:33103
    FHA; FHA domain
  8. XM_030254444.2XP_030110304.1  ras-associating and dilute domain-containing protein isoform X3

    Conserved Domains (3) summary
    cd00992
    Location:752836
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15472
    Location:171538
    Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
    pfam00498
    Location:33103
    FHA; FHA domain

RNA

  1. XR_004942508.1 RNA Sequence

    Related
    ENSMUST00000139824.2
  2. XR_001784688.3 RNA Sequence

  3. XR_377156.5 RNA Sequence