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PASK PAS domain containing serine/threonine kinase [ Homo sapiens (human) ]

Gene ID: 23178, updated on 8-Dec-2018

Summary

Official Symbol
PASKprovided by HGNC
Official Full Name
PAS domain containing serine/threonine kinaseprovided by HGNC
Primary source
HGNC:HGNC:17270
See related
Ensembl:ENSG00000115687 MIM:607505
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STK37; PASKIN
Summary
This gene encodes a member of the serine/threonine kinase family that contains two PAS domains. Expression of this gene is regulated by glucose, and the encoded protein plays a role in the regulation of insulin gene expression. Downregulation of this gene may play a role in type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Expression
Broad expression in testis (RPKM 7.9), lymph node (RPKM 6.8) and 21 other tissues See more
Orthologs

Genomic context

See PASK in Genome Data Viewer
Location:
2q37.3
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (241106099..241150264, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (242045514..242089394, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373970 Neighboring gene sushi, nidogen and EGF like domains 1 Neighboring gene mitochondrial transcription termination factor 4 Neighboring gene uncharacterized LOC105373971 Neighboring gene protein phosphatase 1 regulatory subunit 7 Neighboring gene anoctamin 7 Neighboring gene uncharacterized LOC105376810 Neighboring gene high density lipoprotein binding protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study in Han Chinese identifies three novel loci for human height.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0135, DKFZp434O051, DKFZp686P2031

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
energy homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of glycogen biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of glycogen biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of translation TAS
Traceable Author Statement
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of glucagon secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of respiratory gaseous exchange ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
PAS domain-containing serine/threonine-protein kinase
Names
per-arnt-sim (PAS) domain kinase
NP_001239048.1
NP_001239049.1
NP_001239051.1
NP_001239053.1
NP_055963.2
XP_005247048.1
XP_011509130.1
XP_011509131.1
XP_011509132.1
XP_011509133.1
XP_011509134.1
XP_011509135.1
XP_011509136.1
XP_011509137.1
XP_016859124.1
XP_016859125.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052850.1 RefSeqGene

    Range
    5844..49249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001252119.1NP_001239048.1  PAS domain-containing serine/threonine-protein kinase isoform 1

    See identical proteins and their annotated locations for NP_001239048.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC063585, D50925, DA104684
    Consensus CDS
    CCDS58759.1
    UniProtKB/Swiss-Prot
    Q96RG2
    Related
    ENSP00000351475.4, ENST00000358649.8
    Conserved Domains (5) summary
    smart00091
    Location:344401
    PAS; PAS domain
    smart00220
    Location:9991258
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00130
    Location:133232
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    cd14004
    Location:9981258
    STKc_PASK; Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase
    pfam13426
    Location:133232
    PAS_9; PAS domain
  2. NM_001252120.1NP_001239049.1  PAS domain-containing serine/threonine-protein kinase isoform 2

    See identical proteins and their annotated locations for NP_001239049.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, but maintains the reading frame, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which is shorter than isoform 1.
    Source sequence(s)
    AC005237, BC063585
    Consensus CDS
    CCDS2545.1
    UniProtKB/Swiss-Prot
    Q96RG2
    Related
    ENSP00000441374.2, ENST00000544142.5
    Conserved Domains (5) summary
    smart00091
    Location:344401
    PAS; PAS domain
    smart00220
    Location:9991251
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00130
    Location:133232
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    cd14004
    Location:9981251
    STKc_PASK; Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase
    pfam13426
    Location:133232
    PAS_9; PAS domain
  3. NM_001252122.1NP_001239051.1  PAS domain-containing serine/threonine-protein kinase isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses two alternate splice sites in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AK302417, BC063585, DA104684
    UniProtKB/Swiss-Prot
    Q96RG2
    UniProtKB/TrEMBL
    B7Z7R6
    Conserved Domains (5) summary
    smart00091
    Location:309366
    PAS; PAS domain
    smart00220
    Location:9641216
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00130
    Location:133232
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    cd14004
    Location:9631216
    STKc_PASK; Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase
    pfam13426
    Location:133232
    PAS_9; PAS domain
  4. NM_001252124.1NP_001239053.1  PAS domain-containing serine/threonine-protein kinase isoform 4

    See identical proteins and their annotated locations for NP_001239053.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks a splice site in the 3' coding region, which results in a frameshift and alternate 3' UTR compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL117400, BC050565, BC063585, DA104684
    Consensus CDS
    CCDS58758.1
    UniProtKB/Swiss-Prot
    Q96RG2
    Related
    ENSP00000384438.3, ENST00000403638.7
    Conserved Domains (4) summary
    smart00091
    Location:344401
    PAS; PAS domain
    cd00130
    Location:133232
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam13426
    Location:133232
    PAS_9; PAS domain
    cl21453
    Location:9981115
    PKc_like; Protein Kinases, catalytic domain
  5. NM_015148.3NP_055963.2  PAS domain-containing serine/threonine-protein kinase isoform 2

    See identical proteins and their annotated locations for NP_055963.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, but maintains the reading frame, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which is shorter than isoform 1.
    Source sequence(s)
    BC063585, DA104684
    Consensus CDS
    CCDS2545.1
    UniProtKB/Swiss-Prot
    Q96RG2
    Related
    ENSP00000234040.4, ENST00000234040.8
    Conserved Domains (5) summary
    smart00091
    Location:344401
    PAS; PAS domain
    smart00220
    Location:9991251
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00130
    Location:133232
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    cd14004
    Location:9981251
    STKc_PASK; Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase
    pfam13426
    Location:133232
    PAS_9; PAS domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    241106099..241150264 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510832.2XP_011509134.1  PAS domain-containing serine/threonine-protein kinase isoform X4

    Conserved Domains (2) summary
    smart00220
    Location:8131065
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14004
    Location:8121065
    STKc_PASK; Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase
  2. XM_011510831.2XP_011509133.1  PAS domain-containing serine/threonine-protein kinase isoform X3

    Conserved Domains (2) summary
    smart00220
    Location:8131072
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14004
    Location:8121072
    STKc_PASK; Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase
  3. XM_017003636.1XP_016859125.1  PAS domain-containing serine/threonine-protein kinase isoform X2

    UniProtKB/Swiss-Prot
    Q96RG2
    Conserved Domains (5) summary
    smart00091
    Location:344401
    PAS; PAS domain
    smart00220
    Location:9991251
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00130
    Location:133232
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    cd14004
    Location:9981251
    STKc_PASK; Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase
    pfam13426
    Location:133232
    PAS_9; PAS domain
  4. XM_011510829.2XP_011509131.1  PAS domain-containing serine/threonine-protein kinase isoform X1

    See identical proteins and their annotated locations for XP_011509131.1

    UniProtKB/Swiss-Prot
    Q96RG2
    Conserved Domains (5) summary
    smart00091
    Location:344401
    PAS; PAS domain
    smart00220
    Location:9991258
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00130
    Location:133232
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    cd14004
    Location:9981258
    STKc_PASK; Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase
    pfam13426
    Location:133232
    PAS_9; PAS domain
  5. XM_011510830.2XP_011509132.1  PAS domain-containing serine/threonine-protein kinase isoform X1

    See identical proteins and their annotated locations for XP_011509132.1

    UniProtKB/Swiss-Prot
    Q96RG2
    Conserved Domains (5) summary
    smart00091
    Location:344401
    PAS; PAS domain
    smart00220
    Location:9991258
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00130
    Location:133232
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    cd14004
    Location:9981258
    STKc_PASK; Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase
    pfam13426
    Location:133232
    PAS_9; PAS domain
  6. XM_005246991.1XP_005247048.1  PAS domain-containing serine/threonine-protein kinase isoform X6

    See identical proteins and their annotated locations for XP_005247048.1

    UniProtKB/TrEMBL
    B7Z7V7
    Conserved Domains (2) summary
    smart00220
    Location:7831035
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14004
    Location:7821035
    STKc_PASK; Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase
  7. XM_011510833.1XP_011509135.1  PAS domain-containing serine/threonine-protein kinase isoform X5

    Conserved Domains (2) summary
    smart00220
    Location:7831042
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14004
    Location:7821042
    STKc_PASK; Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase
  8. XM_017003635.1XP_016859124.1  PAS domain-containing serine/threonine-protein kinase isoform X2

    UniProtKB/Swiss-Prot
    Q96RG2
    Conserved Domains (5) summary
    smart00091
    Location:344401
    PAS; PAS domain
    smart00220
    Location:9991251
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00130
    Location:133232
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    cd14004
    Location:9981251
    STKc_PASK; Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase
    pfam13426
    Location:133232
    PAS_9; PAS domain
  9. XM_011510828.1XP_011509130.1  PAS domain-containing serine/threonine-protein kinase isoform X1

    See identical proteins and their annotated locations for XP_011509130.1

    UniProtKB/Swiss-Prot
    Q96RG2
    Conserved Domains (5) summary
    smart00091
    Location:344401
    PAS; PAS domain
    smart00220
    Location:9991258
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00130
    Location:133232
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    cd14004
    Location:9981258
    STKc_PASK; Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase
    pfam13426
    Location:133232
    PAS_9; PAS domain
  10. XM_011510835.1XP_011509137.1  PAS domain-containing serine/threonine-protein kinase isoform X8

    Conserved Domains (2) summary
    smart00220
    Location:542801
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14004
    Location:541801
    STKc_PASK; Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase
  11. XM_011510834.1XP_011509136.1  PAS domain-containing serine/threonine-protein kinase isoform X7

    Conserved Domains (2) summary
    smart00220
    Location:613872
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14004
    Location:612872
    STKc_PASK; Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase

RNA

  1. XR_001738678.2 RNA Sequence

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