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CEP68 centrosomal protein 68 [ Homo sapiens (human) ]

Gene ID: 23177, updated on 12-Oct-2019

Summary

Official Symbol
CEP68provided by HGNC
Official Full Name
centrosomal protein 68provided by HGNC
Primary source
HGNC:HGNC:29076
See related
Ensembl:ENSG00000011523 MIM:616889
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIAA0582
Expression
Ubiquitous expression in brain (RPKM 8.3), ovary (RPKM 8.1) and 25 other tissues See more
Orthologs

Genomic context

See CEP68 in Genome Data Viewer
Location:
2p14
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (65056402..65087004)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (65283495..65314142)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984063 Neighboring gene RNA, U6 small nuclear 548, pseudogene Neighboring gene solute carrier family 1 member 4 Neighboring gene long intergenic non-protein coding RNA 2576 Neighboring gene RAB1A, member RAS oncogene family Neighboring gene voltage dependent anion channel 2 pseudogene Neighboring gene actin related protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of centrosomal protein 68kDa (CEP68) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25920, FLJ36750

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
centriole-centriole cohesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centriole-centriole cohesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
centrosome cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to organelle IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell junction IDA
Inferred from Direct Assay
more info
 
centriolar satellite IDA
Inferred from Direct Assay
more info
 
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
centrosomal protein of 68 kDa
Names
centrosomal protein 68kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319100.2NP_001306029.1  centrosomal protein of 68 kDa isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC007318, AC007386, AK299373, CA398160
    Consensus CDS
    CCDS1880.2
    UniProtKB/Swiss-Prot
    Q76N32
    Conserved Domains (1) summary
    PHA03247
    Location:286443
    PHA03247; large tegument protein UL36; Provisional
  2. NM_001319101.2NP_001306030.1  centrosomal protein of 68 kDa isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AB011154, AC007318, AC007386, BC004873, CA398160
    Consensus CDS
    CCDS82457.1
    UniProtKB/Swiss-Prot
    Q76N32
    Related
    ENSP00000260569.4, ENST00000260569.4
    Conserved Domains (1) summary
    PHA03247
    Location:286443
    PHA03247; large tegument protein UL36; Provisional
  3. NM_015147.3NP_055962.2  centrosomal protein of 68 kDa isoform a

    See identical proteins and their annotated locations for NP_055962.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AB011154, AC007318, CA398160
    Consensus CDS
    CCDS1880.2
    UniProtKB/Swiss-Prot
    Q76N32
    Related
    ENSP00000367229.2, ENST00000377990.7
    Conserved Domains (1) summary
    PHA03247
    Location:286443
    PHA03247; large tegument protein UL36; Provisional

RNA

  1. NR_134966.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB011154, AC007318, AC007386, AK299373, AK304110, CA398160

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    65056402..65087004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003633.2XP_016859122.1  centrosomal protein of 68 kDa isoform X1

    Conserved Domains (1) summary
    PHA03247
    Location:286443
    PHA03247; large tegument protein UL36; Provisional
  2. XM_024452764.1XP_024308532.1  centrosomal protein of 68 kDa isoform X2

    Conserved Domains (1) summary
    cl26464
    Location:286443
    Atrophin-1; Atrophin-1 family
  3. XM_005264219.4XP_005264276.1  centrosomal protein of 68 kDa isoform X1

    Conserved Domains (1) summary
    PHA03247
    Location:286443
    PHA03247; large tegument protein UL36; Provisional

RNA

  1. XR_001738676.2 RNA Sequence

  2. XR_001738677.2 RNA Sequence

  3. XR_939674.3 RNA Sequence

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