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Rimbp2 RIMS binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 231760, updated on 18-Apr-2024

Summary

Official Symbol
Rimbp2provided by MGI
Official Full Name
RIMS binding protein 2provided by MGI
Primary source
MGI:MGI:2443235
See related
Ensembl:ENSMUSG00000029420 AllianceGenome:MGI:2443235
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0318; A930033C01Rik
Summary
Predicted to be involved in neuromuscular synaptic transmission. Located in presynaptic active zone cytoplasmic component. Orthologous to human RIMBP2 (RIMS binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 19.2), frontal lobe adult (RPKM 17.0) and 5 other tissues See more
Orthologs
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Genomic context

Location:
5 G1.3; 5 67.91 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (128834852..129030636, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (128757788..128953644, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14427 Neighboring gene predicted gene, 33995 Neighboring gene piwi-like RNA-mediated gene silencing 1 Neighboring gene predicted gene 42875 Neighboring gene predicted gene, 34057 Neighboring gene syntaxin 2 Neighboring gene RAN, member RAS oncogene family

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in calyx of Held IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in calyx of Held IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in presynaptic active zone cytoplasmic component IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081388.2NP_001074857.1  RIMS-binding protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001074857.1

    Status: VALIDATED

    Source sequence(s)
    AK038814, AK044685, AK147417, BC151100, BP762839, CF745262, CJ115058
    Consensus CDS
    CCDS39288.1
    UniProtKB/Swiss-Prot
    B9EKT4, E9QPF5, Q80U40
    UniProtKB/TrEMBL
    D3YXR8
    Related
    ENSMUSP00000106978.2, ENSMUST00000111346.6
    Conserved Domains (6) summary
    cd12012
    Location:879940
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:9831043
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:192252
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd00063
    Location:508594
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:414478
    fn3; Fibronectin type III domain
    pfam15152
    Location:644685
    Kisspeptin; Kisspeptin
  2. NM_001310733.1NP_001297662.1  RIMS-binding protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC111089, AK044685, AK147417, BC151100, BP762839, CF745262, CJ115058
    Consensus CDS
    CCDS80415.1
    UniProtKB/Swiss-Prot
    B9EKT4, E9QPF5, Q80U40
    UniProtKB/TrEMBL
    A0A0G2JFB0
    Related
    ENSMUSP00000143099.2, ENSMUST00000200470.5
    Conserved Domains (8) summary
    cd12012
    Location:872933
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:9761036
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:185245
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd00063
    Location:501587
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:407471
    fn3; Fibronectin type III domain
    pfam15152
    Location:637678
    Kisspeptin; Kisspeptin
    cd16269
    Location:5670
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:188
    GBP_C; Guanylate-binding protein, C-terminal domain
  3. NM_001378900.1NP_001365829.1  RIMS-binding protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC110566, AC111089, AC116715
    UniProtKB/Swiss-Prot
    B9EKT4, E9QPF5, Q80U40
    Conserved Domains (8) summary
    cd12012
    Location:872933
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:9761036
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:185245
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    smart00060
    Location:314391
    FN3; Fibronectin type 3 domain
    PHA03321
    Location:586730
    PHA03321; tegument protein VP11/12; Provisional
    cd00063
    Location:501587
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:407474
    fn3; Fibronectin type III domain
    pfam15905
    Location:488
    HMMR_N; Hyaluronan mediated motility receptor N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    128834852..129030636 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320870.3XP_017176359.1  RIMS-binding protein 2 isoform X5

    UniProtKB/TrEMBL
    A0A571BDA2
    Conserved Domains (8) summary
    cd12012
    Location:11161177
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:12201280
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:192252
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    PHA03321
    Location:593737
    PHA03321; tegument protein VP11/12; Provisional
    cd00063
    Location:508594
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    TIGR02168
    Location:287
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00041
    Location:414481
    fn3; Fibronectin type III domain
    pfam15152
    Location:644685
    Kisspeptin
  2. XM_006504296.4XP_006504359.1  RIMS-binding protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A571BDA2
    Conserved Domains (8) summary
    cd12012
    Location:11161177
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:12201280
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:192252
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    PHA03321
    Location:593737
    PHA03321; tegument protein VP11/12; Provisional
    cd00063
    Location:508594
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    TIGR02168
    Location:287
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00041
    Location:414481
    fn3; Fibronectin type III domain
    pfam15152
    Location:644685
    Kisspeptin
  3. XM_006504297.5XP_006504360.1  RIMS-binding protein 2 isoform X6

    UniProtKB/TrEMBL
    A0A571BDA2
    Conserved Domains (9) summary
    cd12012
    Location:11091170
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:12131273
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:185245
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    smart00060
    Location:314391
    FN3; Fibronectin type 3 domain
    PHA03321
    Location:586730
    PHA03321; tegument protein VP11/12; Provisional
    cd00063
    Location:501587
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:407474
    fn3; Fibronectin type III domain
    pfam15152
    Location:637678
    Kisspeptin
    pfam15905
    Location:888
    HMMR_N; Hyaluronan mediated motility receptor N-terminal
  4. XM_006504288.5XP_006504351.1  RIMS-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006504351.1

    UniProtKB/TrEMBL
    A0A571BDA2
    Conserved Domains (7) summary
    cd12012
    Location:11161177
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:12201280
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:192252
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    PHA03321
    Location:593737
    PHA03321; tegument protein VP11/12; Provisional
    cd00063
    Location:508594
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    TIGR02168
    Location:287
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00041
    Location:414481
    fn3; Fibronectin type III domain
  5. XM_006504295.5XP_006504358.1  RIMS-binding protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A571BDA2
    Conserved Domains (7) summary
    cd12012
    Location:10671128
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:11711231
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:192252
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd00063
    Location:508594
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    TIGR02168
    Location:287
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00041
    Location:414481
    fn3; Fibronectin type III domain
    pfam15152
    Location:644685
    Kisspeptin
  6. XM_006504289.5XP_006504352.1  RIMS-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006504352.1

    UniProtKB/TrEMBL
    A0A571BDA2
    Conserved Domains (7) summary
    cd12012
    Location:11161177
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:12201280
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:192252
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    PHA03321
    Location:593737
    PHA03321; tegument protein VP11/12; Provisional
    cd00063
    Location:508594
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    TIGR02168
    Location:287
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00041
    Location:414481
    fn3; Fibronectin type III domain
  7. XM_006504293.4XP_006504356.1  RIMS-binding protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006504356.1

    UniProtKB/TrEMBL
    A0A571BDA2
    Conserved Domains (9) summary
    cd12012
    Location:11091170
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:12131273
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:185245
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    smart00060
    Location:314391
    FN3; Fibronectin type 3 domain
    PHA03321
    Location:586730
    PHA03321; tegument protein VP11/12; Provisional
    cd00063
    Location:501587
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:407474
    fn3; Fibronectin type III domain
    pfam15152
    Location:637678
    Kisspeptin
    pfam15905
    Location:888
    HMMR_N; Hyaluronan mediated motility receptor N-terminal
  8. XM_030254432.1XP_030110292.1  RIMS-binding protein 2 isoform X8

    UniProtKB/TrEMBL
    A0A0G2JGW5
    Related
    ENSMUSP00000143725.2, ENSMUST00000196085.5
    Conserved Domains (8) summary
    cd12012
    Location:830891
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:934994
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:192252
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    PHA03321
    Location:593709
    PHA03321; tegument protein VP11/12; Provisional
    cd00063
    Location:508594
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    TIGR02168
    Location:287
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00041
    Location:414481
    fn3; Fibronectin type III domain
    pfam15152
    Location:644685
    Kisspeptin
  9. XM_017320871.2XP_017176360.1  RIMS-binding protein 2 isoform X7

    UniProtKB/Swiss-Prot
    B9EKT4, E9QPF5, Q80U40
    Conserved Domains (9) summary
    cd12012
    Location:879940
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:9831043
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:192252
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    smart00060
    Location:321398
    FN3; Fibronectin type 3 domain
    PHA03321
    Location:593737
    PHA03321; tegument protein VP11/12; Provisional
    cd00063
    Location:508594
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    TIGR02168
    Location:287
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00041
    Location:414481
    fn3; Fibronectin type III domain
    pfam15152
    Location:644685
    Kisspeptin
  10. XM_036165094.1XP_036020987.1  RIMS-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A571BDA2
    Conserved Domains (7) summary
    cd12012
    Location:11161177
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:12201280
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:192252
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    PHA03321
    Location:593737
    PHA03321; tegument protein VP11/12; Provisional
    cd00063
    Location:508594
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    TIGR02168
    Location:287
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00041
    Location:414481
    fn3; Fibronectin type III domain
  11. XM_006504294.5XP_006504357.1  RIMS-binding protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006504357.1

    UniProtKB/TrEMBL
    A0A571BDA2
    Related
    ENSMUSP00000158659.2, ENSMUST00000238334.2
    Conserved Domains (9) summary
    cd12012
    Location:11091170
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:12131273
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:185245
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    smart00060
    Location:314391
    FN3; Fibronectin type 3 domain
    PHA03321
    Location:586730
    PHA03321; tegument protein VP11/12; Provisional
    cd00063
    Location:501587
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:407474
    fn3; Fibronectin type III domain
    pfam15152
    Location:637678
    Kisspeptin
    pfam15905
    Location:888
    HMMR_N; Hyaluronan mediated motility receptor N-terminal
  12. XM_011240839.4XP_011239141.1  RIMS-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011239141.1

    UniProtKB/TrEMBL
    A0A571BDA2
    Conserved Domains (7) summary
    cd12012
    Location:11161177
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:12201280
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:192252
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    PHA03321
    Location:593737
    PHA03321; tegument protein VP11/12; Provisional
    cd00063
    Location:508594
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    TIGR02168
    Location:287
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00041
    Location:414481
    fn3; Fibronectin type III domain

RNA

  1. XR_377055.5 RNA Sequence