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ZCCHC14 zinc finger CCHC-type containing 14 [ Homo sapiens (human) ]

Gene ID: 23174, updated on 1-Aug-2020

Summary

Official Symbol
ZCCHC14provided by HGNC
Official Full Name
zinc finger CCHC-type containing 14provided by HGNC
Primary source
HGNC:HGNC:24134
See related
Ensembl:ENSG00000140948
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BDG29; BDG-29
Expression
Broad expression in testis (RPKM 26.9), ovary (RPKM 7.6) and 24 other tissues See more
Orthologs

Genomic context

See ZCCHC14 in Genome Data Viewer
Location:
16q24.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (87406248..87493024, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (87439852..87525870, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene F-box protein 31 Neighboring gene tRNA-Met (anticodon CAT) 6-1 Neighboring gene microtubule associated protein 1 light chain 3 beta Neighboring gene nuclear receptor subfamily 3 group C member 1 pseudogene 1 Neighboring gene uncharacterized LOC101928737 Neighboring gene junctophilin 3 repeat instability region Neighboring gene junctophilin 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of zinc finger, CCHC domain containing 14 (ZCCHC14) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC14139, MGC126527

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger CCHC domain-containing protein 14
Names
zinc finger, CCHC domain containing 14

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015144.3NP_055959.2  zinc finger CCHC domain-containing protein 14

    Status: VALIDATED

    Source sequence(s)
    AC010531, AC092720, AC105429
    Consensus CDS
    CCDS10961.1
    Related
    ENSP00000499622.1, ENST00000671377.2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    87406248..87493024 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255858.3XP_005255915.2  zinc finger CCHC domain-containing protein 14 isoform X1

    UniProtKB/Swiss-Prot
    Q8WYQ9
    Related
    ENSP00000456499.1, ENST00000561928.1
    Conserved Domains (4) summary
    cd09558
    Location:294358
    SAM_ZCCH14; SAM domain of ZCCH14 subfamily
    smart00454
    Location:301352
    SAM; Sterile alpha motif
    pfam00098
    Location:908923
    zf-CCHC; Zinc knuckle
    cl02563
    Location:119202
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  2. XM_017023082.2XP_016878571.1  zinc finger CCHC domain-containing protein 14 isoform X2

  3. XM_011522964.2XP_011521266.1  zinc finger CCHC domain-containing protein 14 isoform X3

    Conserved Domains (3) summary
    smart00454
    Location:438489
    SAM; Sterile alpha motif
    cl02563
    Location:256339
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl15755
    Location:431492
    SAM_superfamily; SAM (Sterile alpha motif )

RNA

  1. XR_243401.3 RNA Sequence

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