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Rad9b RAD9 checkpoint clamp component B [ Mus musculus (house mouse) ]

Gene ID: 231724, updated on 26-Sep-2022

Summary

Official Symbol
Rad9bprovided by MGI
Official Full Name
RAD9 checkpoint clamp component Bprovided by MGI
Primary source
MGI:MGI:2385231
See related
Ensembl:ENSMUSG00000038569 AllianceGenome:MGI:2385231
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A630082N15Rik
Summary
Predicted to be involved in DNA integrity checkpoint signaling; DNA repair; and cellular response to ionizing radiation. Predicted to be located in nucleus. Predicted to be part of checkpoint clamp complex. Is expressed in embryo and future brain. Orthologous to human RAD9B (RAD9 checkpoint clamp component B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 5.4), testis adult (RPKM 5.1) and 28 other tissues See more
Orthologs
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Genomic context

See Rad9b in Genome Data Viewer
Location:
5; 5 F
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (122461286..122492297, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (122323223..122354270, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene hydrogen voltage-gated channel 1 Neighboring gene tectonic family member 1 Neighboring gene RIKEN cDNA 1700112N08 gene Neighboring gene PTC7 protein phosphatase homolog Neighboring gene VPS29 retromer complex component Neighboring gene family with sequence similarity 216, member A Neighboring gene predicted gene, 32853 Neighboring gene GPN-loop GTPase 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Clone Names

  • MGC28469

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to ionizing radiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic intra-S DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of checkpoint clamp complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
cell cycle checkpoint control protein RAD9B
Names
DNA repair exonuclease rad9 homolog B
RAD9 homolog B
cell cycle checkpoint control protein RAD9B homolog
mRAD9B
NP_001369782.1
NP_659161.2
XP_006530368.1
XP_006530369.1
XP_006530371.1
XP_006530373.1
XP_017176358.1
XP_036020985.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001382853.1NP_001369782.1  cell cycle checkpoint control protein RAD9B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC093473, AC113285
    Related
    ENSMUSP00000113868.3, ENSMUST00000117263.8
    Conserved Domains (1) summary
    pfam04139
    Location:14271
    Rad9
  2. NM_144912.4NP_659161.2  cell cycle checkpoint control protein RAD9B isoform 1

    See identical proteins and their annotated locations for NP_659161.2

    Status: VALIDATED

    Source sequence(s)
    AC093473, AC113285
    Consensus CDS
    CCDS19646.1
    UniProtKB/Swiss-Prot
    Q6WBX7
    UniProtKB/TrEMBL
    Q8VC54
    Related
    ENSMUSP00000036177.7, ENSMUST00000049009.7
    Conserved Domains (2) summary
    cd00577
    Location:10273
    PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
    pfam04139
    Location:14271
    Rad9; Rad9

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    122461286..122492297 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530310.4XP_006530373.1  cell cycle checkpoint control protein RAD9B isoform X4

    Conserved Domains (1) summary
    pfam04139
    Location:1118
    Rad9
  2. XM_017320869.3XP_017176358.1  cell cycle checkpoint control protein RAD9B isoform X3

    Conserved Domains (1) summary
    pfam04139
    Location:21203
    Rad9
  3. XM_006530306.5XP_006530369.1  cell cycle checkpoint control protein RAD9B isoform X1

    See identical proteins and their annotated locations for XP_006530369.1

    Conserved Domains (1) summary
    pfam04139
    Location:21278
    Rad9
  4. XM_006530305.5XP_006530368.1  cell cycle checkpoint control protein RAD9B isoform X1

    See identical proteins and their annotated locations for XP_006530368.1

    Conserved Domains (1) summary
    pfam04139
    Location:21278
    Rad9
  5. XM_006530308.5XP_006530371.1  cell cycle checkpoint control protein RAD9B isoform X2

    Conserved Domains (1) summary
    pfam04139
    Location:21228
    Rad9
  6. XM_036165092.1XP_036020985.1  cell cycle checkpoint control protein RAD9B isoform X3

    Conserved Domains (1) summary
    pfam04139
    Location:21203
    Rad9

RNA

  1. XR_001784685.3 RNA Sequence

  2. XR_004942507.1 RNA Sequence

  3. XR_001784684.3 RNA Sequence

  4. XR_387562.5 RNA Sequence