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ABRAXAS2 abraxas 2, BRISC complex subunit [ Homo sapiens (human) ]

Gene ID: 23172, updated on 3-May-2020

Summary

Official Symbol
ABRAXAS2provided by HGNC
Official Full Name
abraxas 2, BRISC complex subunitprovided by HGNC
Primary source
HGNC:HGNC:28975
See related
Ensembl:ENSG00000165660 MIM:611144
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ABRO1; FAM175B; KIAA0157
Expression
Ubiquitous expression in thyroid (RPKM 8.5), lymph node (RPKM 6.8) and 25 other tissues See more
Orthologs

Genomic context

See ABRAXAS2 in Genome Data Viewer
Location:
10q26.13
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (124801803..124836670)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (126490354..126525239)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 53 member B Neighboring gene Sharpr-MPRA regulatory region 10105 Neighboring gene FAM53B antisense RNA 1 Neighboring gene EEF1A lysine methyltransferase 2 Neighboring gene uncharacterized LOC107984160 Neighboring gene nucleophosmin 1 pseudogene 31 Neighboring gene zinc finger RANBP2-type containing 1 Neighboring gene C-terminal binding protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22338, KIAA0157

Gene Ontology Provided by GOA

Function Evidence Code Pubs
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
attachment of spindle microtubules to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
attachment of spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell division IEA
Inferred from Electronic Annotation
more info
 
chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein K63-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K63-linked deubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
response to ischemia IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
BRISC complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
colocalizes_with microtubule minus-end IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with midbody IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with spindle pole centrosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
BRISC complex subunit Abraxas 2
Names
BRISC complex subunit Abro1
abraxas brother 1
abraxas brother protein 1
family with sequence similarity 175 member B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032182.4NP_115558.3  BRISC complex subunit Abraxas 2

    See identical proteins and their annotated locations for NP_115558.3

    Status: VALIDATED

    Source sequence(s)
    AC068896
    Consensus CDS
    CCDS31308.2
    UniProtKB/Swiss-Prot
    Q15018
    Related
    ENSP00000298492.5, ENST00000298492.6
    Conserved Domains (1) summary
    pfam10234
    Location:189279
    Cluap1; Clusterin-associated protein-1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    124801803..124836670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015986.1XP_016871475.1  BRISC complex subunit Abraxas 2 isoform X1

    Conserved Domains (1) summary
    pfam10234
    Location:85175
    Cluap1; Clusterin-associated protein-1
  2. XM_011539554.1XP_011537856.1  BRISC complex subunit Abraxas 2 isoform X1

    See identical proteins and their annotated locations for XP_011537856.1

    Conserved Domains (1) summary
    pfam10234
    Location:85175
    Cluap1; Clusterin-associated protein-1
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