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Naa25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit [ Mus musculus (house mouse) ]

Gene ID: 231713, updated on 21-Apr-2024

Summary

Official Symbol
Naa25provided by MGI
Official Full Name
N(alpha)-acetyltransferase 25, NatB auxiliary subunitprovided by MGI
Primary source
MGI:MGI:2442563
See related
Ensembl:ENSMUSG00000042719 AllianceGenome:MGI:2442563
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mdm20; A630046C11; 4833422K13Rik; C330023M02Rik
Summary
Predicted to contribute to peptide alpha-N-acetyltransferase activity. Predicted to be involved in N-terminal peptidyl-methionine acetylation. Predicted to be located in Golgi apparatus and cytosol. Predicted to be part of NatB complex. Predicted to be active in cytoplasm. Is expressed in several structures, including brain; hair; heart; spinal cord; and stomach. Orthologous to human NAA25 (N-alpha-acetyltransferase 25, NatB auxiliary subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 10.4), whole brain E14.5 (RPKM 8.5) and 28 other tissues See more
Orthologs
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Genomic context

Location:
5 F; 5 61.79 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (121535977..121580612)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (121397914..121442549)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene HECT domain E3 ubiquitin protein ligase 4 Neighboring gene predicted gene, 24671 Neighboring gene TRAF type zinc finger domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E1688 Neighboring gene predicted gene, 42020 Neighboring gene STARR-seq mESC enhancer starr_14257 Neighboring gene STARR-positive B cell enhancer ABC_E6373 Neighboring gene STARR-positive B cell enhancer ABC_E6374 Neighboring gene endoplasmic reticulum protein 29 Neighboring gene transmembrane protein 116 Neighboring gene mitogen-activated protein kinase 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (3) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in N-terminal peptidyl-methionine acetylation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
part_of NatB complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of NatB complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
N-alpha-acetyltransferase 25, NatB auxiliary subunit
Names
N-terminal acetyltransferase B complex subunit MDM20
N-terminal acetyltransferase B complex subunit NAA25
mitochondrial distribution and morphology protein 20
natB complex subunit MDM20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172722.4NP_766310.2  N-alpha-acetyltransferase 25, NatB auxiliary subunit

    See identical proteins and their annotated locations for NP_766310.2

    Status: VALIDATED

    Source sequence(s)
    AC129215, AK049325, AK051815, AK076483, BX521975, CF742186
    Consensus CDS
    CCDS19633.1
    UniProtKB/Swiss-Prot
    A1A4B7, Q3KQI7, Q3TJC6, Q7TMM2, Q8BWZ3
    UniProtKB/TrEMBL
    B2RQV1
    Related
    ENSMUSP00000038977.9, ENSMUST00000042163.15
    Conserved Domains (2) summary
    sd00006
    Location:4773
    TPR; TPR repeat [structural motif]
    pfam09797
    Location:263655
    NatB_MDM20; N-acetyltransferase B complex (NatB) non catalytic subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    121535977..121580612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248198.3XP_011246500.1  N-alpha-acetyltransferase 25, NatB auxiliary subunit isoform X1

    Conserved Domains (3) summary
    TIGR02917
    Location:2185
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:1945
    TPR; TPR repeat [structural motif]
    pfam09797
    Location:236630
    NatB_MDM20; N-acetyltransferase B complex (NatB) non catalytic subunit

RNA

  1. XR_001784683.2 RNA Sequence