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GPD1L glycerol-3-phosphate dehydrogenase 1 like [ Homo sapiens (human) ]

Gene ID: 23171, updated on 3-Jun-2018
Official Symbol
GPD1Lprovided by HGNC
Official Full Name
glycerol-3-phosphate dehydrogenase 1 likeprovided by HGNC
Primary source
See related
Ensembl:ENSG00000152642 MIM:611778; Vega:OTTHUMG00000155846
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
The protein encoded by this gene catalyzes the conversion of sn-glycerol 3-phosphate to glycerone phosphate. The encoded protein is found in the cytoplasm, associated with the plasma membrane, where it binds the sodium channel, voltage-gated, type V, alpha subunit (SCN5A). Defects in this gene are a cause of Brugada syndrome type 2 (BRS2) as well as sudden infant death syndrome (SIDS). [provided by RefSeq, Jul 2010]
Broad expression in heart (RPKM 51.9), prostate (RPKM 37.6) and 23 other tissues See more
See GPD1L in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (32106511..32168715)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (32148003..32210207)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L21 pseudogene 40 Neighboring gene nucleolar protein interacting with the FHA domain of MKI67 pseudogene 7 Neighboring gene ribosomal protein SA pseudogene 11 Neighboring gene CKLF like MARVEL transmembrane domain containing 8 Neighboring gene keratin 18 pseudogene 15

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Brugada syndrome 2
MedGen: C2673193 OMIM: 611777 GeneReviews: Brugada Syndrome
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Genome-wide association study of periodontal health measured by probing depth in adults ages 18-49 years.
Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster.
  • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
    Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
  • Glycerophospholipid biosynthesis, organism-specific biosystem (from REACTOME)
    Glycerophospholipid biosynthesis, organism-specific biosystemGlycerophospholipids are important structural and functional components of biological membranes and constituents of serum lipoproteins and the pulmonary surfactant. In addition, glycerophospholipids...
  • Glycerophospholipid metabolism, organism-specific biosystem (from KEGG)
    Glycerophospholipid metabolism, organism-specific biosystem
    Glycerophospholipid metabolism
  • Glycerophospholipid metabolism, conserved biosystem (from KEGG)
    Glycerophospholipid metabolism, conserved biosystem
    Glycerophospholipid metabolism
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Phospholipid metabolism, organism-specific biosystem (from REACTOME)
    Phospholipid metabolism, organism-specific biosystemPhospholipids contain a polar head group and two long-chain fatty acyl moieties, one of which is generally unsaturated. The head group is a glycerol or serine phosphate attached to a polar group such...
  • Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
    Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
  • Synthesis of PA, organism-specific biosystem (from REACTOME)
    Synthesis of PA, organism-specific biosystemIn the de novo synthesis of phosphatidic acid (PA), lysophosphatidic acid (LPA) is initially formed by the esterification of sn-1 by glycerol 3-phosphate acyltransferase (GPAT) from glycerol 3-phosph...
  • Triglyceride Biosynthesis, organism-specific biosystem (from REACTOME)
    Triglyceride Biosynthesis, organism-specific biosystemThe overall process of triglyceride (triacylglycerol) biosynthesis consists of four biochemical pathways: fatty acyl-CoA biosynthesis, conversion of fatty acyl-CoA to phosphatidic acid, conversion of...
Products Interactant Other Gene Complex Source Pubs Description



Clone Names

  • KIAA0089

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD binding IEA
Inferred from Electronic Annotation
more info
glycerol-3-phosphate dehydrogenase [NAD+] activity TAS
Traceable Author Statement
more info
ion channel binding IPI
Inferred from Physical Interaction
more info
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
sodium channel regulator activity IMP
Inferred from Mutant Phenotype
more info
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
extracellular exosome HDA PubMed 
glycerol-3-phosphate dehydrogenase complex IEA
Inferred from Electronic Annotation
more info
plasma membrane IDA
Inferred from Direct Assay
more info
Preferred Names
glycerol-3-phosphate dehydrogenase 1-like protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.


  1. NG_023375.1 RefSeqGene

    GenBank, FASTA, Sequence Viewer (Graphics), LRG_419

mRNA and Protein(s)

  1. NM_015141.3NP_055956.1  glycerol-3-phosphate dehydrogenase 1-like protein

    See identical proteins and their annotated locations for NP_055956.1

    Status: REVIEWED

    Source sequence(s)
    AI080105, AK292808, BC028726, BX283865, DA318838
    Consensus CDS
    ENSP00000282541.5, OTTHUMP00000208779, ENST00000282541.9, OTTHUMT00000341975
    Conserved Domains (1) summary
    glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly


  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713068.2XP_006713131.1  glycerol-3-phosphate dehydrogenase 1-like protein isoform X1

    Conserved Domains (3) summary
    glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))
    NAD_Gly3P_dh_C; NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
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