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TTLL12 tubulin tyrosine ligase like 12 [ Homo sapiens (human) ]

Gene ID: 23170, updated on 5-Sep-2021

Summary

Official Symbol
TTLL12provided by HGNC
Official Full Name
tubulin tyrosine ligase like 12provided by HGNC
Primary source
HGNC:HGNC:28974
See related
Ensembl:ENSG00000100304 MIM:619410
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
dJ526I14.2
Expression
Ubiquitous expression in esophagus (RPKM 28.7), colon (RPKM 16.0) and 25 other tissues See more
Orthologs
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Genomic context

See TTLL12 in Genome Data Viewer
Location:
22q13.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (43166622..43187134, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (43562628..43583140, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene malonyl-CoA-acyl carrier protein transacylase Neighboring gene translocator protein Neighboring gene signal peptide, CUB domain and EGF like domain containing 1 Neighboring gene SCUBE1 antisense RNA 2 Neighboring gene SCUBE1 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study (GWAS) for molar-incisor hypomineralization (MIH).
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of HIV-1 Tat upregulates the abundance of tubulin tyrosine ligase-like family, member 12 (TTLL12) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41795, KIAA0153

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables H4K20me3 modified histone binding IDA
Inferred from Direct Assay
more info
PubMed 
NOT enables histone-lysine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
NOT enables tubulin-tyrosine ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
located_in midbody IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in spindle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tubulin--tyrosine ligase-like protein 12
Names
inactive tubulin--tyrosine ligase-like protein 12
tubulin tyrosine ligase-like family, member 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015140.4NP_055955.1  tubulin--tyrosine ligase-like protein 12

    See identical proteins and their annotated locations for NP_055955.1

    Status: VALIDATED

    Source sequence(s)
    BC001070, BE785973, BX411143, Z82214
    Consensus CDS
    CCDS14047.1
    UniProtKB/Swiss-Prot
    Q14166
    UniProtKB/TrEMBL
    A0A024R4U3
    Related
    ENSP00000216129.6, ENST00000216129.7
    Conserved Domains (1) summary
    pfam03133
    Location:346642
    TTL; Tubulin-tyrosine ligase family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    43166622..43187134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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