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Fbxw8 F-box and WD-40 domain protein 8 [ Mus musculus (house mouse) ]

Gene ID: 231672, updated on 12-May-2024

Summary

Official Symbol
Fbxw8provided by MGI
Official Full Name
F-box and WD-40 domain protein 8provided by MGI
Primary source
MGI:MGI:1923041
See related
Ensembl:ENSMUSG00000032867 AllianceGenome:MGI:1923041
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FBW6; FBW8; Fbx29; FBXO29; 4930438M06Rik
Summary
Predicted to contribute to ubiquitin-protein transferase activity. Involved in positive regulation of transcription factor catabolic process and protein ubiquitination. Acts upstream of or within labyrinthine layer blood vessel development and spongiotrophoblast layer development. Part of Cul7-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. Is expressed in several structures, including heart; liver; lung; placenta; and spleen. Orthologous to human FBXW8 (F-box and WD repeat domain containing 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 39.6), subcutaneous fat pad adult (RPKM 36.4) and 28 other tissues See more
Orthologs
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Genomic context

See Fbxw8 in Genome Data Viewer
Location:
5 F; 5 57.92 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (118203046..118293523, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (118064981..118155458, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4781 Neighboring gene F-box protein 21 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:118486912-118487121 Neighboring gene tescalcin Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:118531602-118531711 Neighboring gene predicted gene 9754 Neighboring gene predicted gene, 30466 Neighboring gene STARR-seq mESC enhancer starr_14188 Neighboring gene predicted gene, 26411 Neighboring gene predicted gene, 30522 Neighboring gene harakiri, BCL2 interacting protein (contains only BH3 domain)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IC
Inferred by Curator
more info
PubMed 
contributes_to ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of 3M complex ISO
Inferred from Sequence Orthology
more info
 
part_of Cul7-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Cul7-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of Cul7-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
part_of SCF ubiquitin ligase complex IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
F-box/WD repeat-containing protein 8
Names
F-box and WD-40 domain-containing protein 8
F-box protein FBX29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172721.2NP_766309.2  F-box/WD repeat-containing protein 8

    See identical proteins and their annotated locations for NP_766309.2

    Status: VALIDATED

    Source sequence(s)
    AK034447, AK053794, BY468586
    Consensus CDS
    CCDS19609.1
    UniProtKB/Swiss-Prot
    Q8BI62, Q8BI75, Q8BI76, Q8BIA4, Q8CID8, Q921Z1
    Related
    ENSMUSP00000047012.8, ENSMUST00000049474.9
    Conserved Domains (4) summary
    COG2319
    Location:263588
    WD40; WD40 repeat [General function prediction only]
    pfam12937
    Location:118162
    F-box-like; F-box-like
    sd00039
    Location:213252
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:209501
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    118203046..118293523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)