U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gcn1 GCN1 activator of EIF2AK4 [ Mus musculus (house mouse) ]

Gene ID: 231659, updated on 8-Jan-2023

Summary

Official Symbol
Gcn1provided by MGI
Official Full Name
GCN1 activator of EIF2AK4provided by MGI
Primary source
MGI:MGI:2444248
See related
Ensembl:ENSMUSG00000041638 AllianceGenome:MGI:2444248
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GCN1L; Gcn1l1; mKIAA0219; 4932409G22; G431004K08Rik
Summary
Predicted to enable protein kinase binding activity; protein kinase regulator activity; and ribosome binding activity. Involved in cellular response to leucine starvation and positive regulation of transcription from RNA polymerase II promoter in response to stress. Part of polysome. Is expressed in several structures, including gut; heart; hemolymphoid system gland; liver; and lung. Orthologous to human GCN1 (GCN1 activator of EIF2AK4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 25.3), thymus adult (RPKM 23.0) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Gcn1 in Genome Data Viewer
Location:
5; 5 F
Exon count:
58
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (115703177..115760713)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (115565117..115622654)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene paxillin Neighboring gene predicted gene 13840 Neighboring gene ribosomal protein, large, P0 Neighboring gene microRNA 7029 Neighboring gene RIKEN cDNA 1110006O24 gene Neighboring gene RAB35, member RAS oncogene family Neighboring gene microRNA 7030

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
 
enables translation activator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to amino acid starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to amino acid starvation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to leucine starvation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of polysome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
eIF-2-alpha kinase activator GCN1
Names
GCN1 eIF-2-alpha kinase activator homolog
GCN1 general control of amino-acid synthesis 1-like 1
GCN1-like protein 1
general control of amino-acid synthesis 1-like protein 1
translational activator GCN1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172719.2NP_766307.2  eIF-2-alpha kinase activator GCN1

    Status: VALIDATED

    Source sequence(s)
    AK077013, AK089324, AK147257, BY582410, CD350892, CJ104712
    Consensus CDS
    CCDS19595.1
    UniProtKB/Swiss-Prot
    B2RWW6, E9PVA8
    UniProtKB/TrEMBL
    Q3UHQ5, Q8BIX2, Q8BTM7
    Related
    ENSMUSP00000069432.8, ENSMUST00000064454.12
    Conserved Domains (4) summary
    cd00020
    Location:14981601
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam12074
    Location:355705
    DUF3554; Domain of unknown function (DUF3554)
    pfam13646
    Location:16161721
    HEAT_2; HEAT repeats
    sd00044
    Location:14611485
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    115703177..115760713
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001784681.3 RNA Sequence