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Oasl1 2'-5' oligoadenylate synthetase-like 1 [ Mus musculus (house mouse) ]

Gene ID: 231655, updated on 12-May-2024

Summary

Official Symbol
Oasl1provided by MGI
Official Full Name
2'-5' oligoadenylate synthetase-like 1provided by MGI
Primary source
MGI:MGI:2180849
See related
Ensembl:ENSMUSG00000041827 AllianceGenome:MGI:2180849
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
oasl9; 7530414C13Rik
Summary
Enables double-stranded RNA binding activity. Acts upstream of or within interleukin-27-mediated signaling pathway. Predicted to be located in cytoplasm and nucleolus. Predicted to be active in cytosol; membrane; and nucleoplasm. Is expressed in testis. Orthologous to human OASL (2'-5'-oligoadenylate synthetase like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in small intestine adult (RPKM 38.2), stomach adult (RPKM 33.5) and 9 other tissues See more
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Genomic context

See Oasl1 in Genome Data Viewer
Location:
5 F; 5 55.99 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (115061236..115075970)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (114923143..114937911)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene 2'-5' oligoadenylate synthetase-like 2 Neighboring gene predicted gene 13822 Neighboring gene RIKEN cDNA 2210016L21 gene Neighboring gene STARR-positive B cell enhancer ABC_E1057 Neighboring gene HNF1 homeobox A Neighboring gene HNF1 homeobox A, opposite strand 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables 2'-5'-oligoadenylate synthetase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in interleukin-27-mediated signaling pathway IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in negative regulation of viral genome replication IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of RIG-I signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
2'-5'-oligoadenylate synthase-like protein 1
Names
2',5'-oligoadenylate synthetase-like 9
2,5-oligoadenylate synthetase-like 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359945.1NP_001346874.1  2'-5'-oligoadenylate synthase-like protein 1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC117799, AK150863
    Consensus CDS
    CCDS19575.1
    UniProtKB/Swiss-Prot
    Q3UBP8, Q8K2A2, Q8QZV5, Q8VI94
    Related
    ENSMUSP00000107771.4, ENSMUST00000112143.4
    Conserved Domains (4) summary
    cd05400
    Location:29208
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    pfam00240
    Location:432498
    ubiquitin; Ubiquitin family
    pfam10421
    Location:165347
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
    cl00155
    Location:350429
    UBQ; Ubiquitin-like proteins
  2. NM_001359946.1NP_001346875.1  2'-5'-oligoadenylate synthase-like protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC117799
    Conserved Domains (3) summary
    pfam00240
    Location:253319
    ubiquitin; Ubiquitin family
    pfam10421
    Location:9168
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
    cl00155
    Location:171250
    UBQ; Ubiquitin-like proteins
  3. NM_145209.3NP_660210.1  2'-5'-oligoadenylate synthase-like protein 1 isoform a

    See identical proteins and their annotated locations for NP_660210.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AK078690
    Consensus CDS
    CCDS19575.1
    UniProtKB/Swiss-Prot
    Q3UBP8, Q8K2A2, Q8QZV5, Q8VI94
    Related
    ENSMUSP00000031540.5, ENSMUST00000031540.11
    Conserved Domains (4) summary
    cd05400
    Location:29208
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    pfam00240
    Location:432498
    ubiquitin; Ubiquitin family
    pfam10421
    Location:165347
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
    cl00155
    Location:350429
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    115061236..115075970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530295.5XP_006530358.1  2'-5'-oligoadenylate synthase-like protein 1 isoform X1

    Conserved Domains (2) summary
    cd05400
    Location:29208
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    pfam10421
    Location:165215
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus