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Tmem119 transmembrane protein 119 [ Mus musculus (house mouse) ]

Gene ID: 231633, updated on 10-Jan-2023

Summary

Official Symbol
Tmem119provided by MGI
Official Full Name
transmembrane protein 119provided by MGI
Primary source
MGI:MGI:2385228
See related
Ensembl:ENSMUSG00000054675 AllianceGenome:MGI:2385228
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
obif
Summary
Involved in several processes, including endochondral ossification; negative regulation of bone resorption; and positive regulation of macromolecule metabolic process. Acts upstream of or within osteoblast differentiation. Located in endoplasmic reticulum and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and skeleton. Orthologous to human TMEM119 (transmembrane protein 119). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 33.8), subcutaneous fat pad adult (RPKM 29.7) and 19 other tissues See more
Orthologs
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Genomic context

See Tmem119 in Genome Data Viewer
Location:
5; 5 F
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (113931790..113938530, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (113793729..113800396, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene squamous cell carcinoma antigen recognized by T cells 3 Neighboring gene 40S ribosomal protein S28 pseudogene Neighboring gene iron-sulfur cluster assembly enzyme Neighboring gene predicted gene, 42004 Neighboring gene protein LLP homolog

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Clone Names

  • MGC38046

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within biomineral tissue development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in endochondral ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of bone resorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of myotube differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within ossification IEA
Inferred from Electronic Annotation
more info
 
involved_in ossification IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within osteoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of bone development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of bone mineralization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of osteoblast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of osteoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of osteoblast proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of osteoblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of osteoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in spermatid differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transmembrane protein 119
Names
osteoblast induction factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146162.3NP_666274.1  transmembrane protein 119 precursor

    See identical proteins and their annotated locations for NP_666274.1

    Status: VALIDATED

    Source sequence(s)
    AC132939
    Consensus CDS
    CCDS19554.1
    UniProtKB/Swiss-Prot
    Q8BP14, Q8R138
    Related
    ENSMUSP00000070551.6, ENSMUST00000067853.6
    Conserved Domains (1) summary
    pfam15724
    Location:20274
    TMEM119; TMEM119 family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    113931790..113938530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165089.1XP_036020982.1  transmembrane protein 119 isoform X1

    UniProtKB/Swiss-Prot
    Q8BP14
    Conserved Domains (1) summary
    pfam15724
    Location:20274
    TMEM119; TMEM119 family