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MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 [ Homo sapiens (human) ]

Gene ID: 23162, updated on 17-Oct-2021

Summary

Official Symbol
MAPK8IP3provided by HGNC
Official Full Name
mitogen-activated protein kinase 8 interacting protein 3provided by HGNC
Primary source
HGNC:HGNC:6884
See related
Ensembl:ENSG00000138834 MIM:605431
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
syd; JIP3; SYD2; JIP-3; JSAP1; NEDBA
Summary
The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 22.4), spleen (RPKM 12.7) and 24 other tissues See more
Orthologs
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Genomic context

See MAPK8IP3 in Genome Data Viewer
Location:
16p13.3
Exon count:
33
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (1706183..1770351)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1756196..1820352)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene cramped chromatin regulator homolog 1 Neighboring gene Jupiter microtubule associated homolog 2 Neighboring gene uncharacterized LOC101929480 Neighboring gene microRNA 3177 Neighboring gene mitochondrial ribosomal protein S34 Neighboring gene NME/NM23 nucleoside diphosphate kinase 3 Neighboring gene essential meiotic structure-specific endonuclease subunit 2 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ00027, KIAA1066, DKFZp762N1113

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables JUN kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables MAP-kinase scaffold activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables MAP-kinase scaffold activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables kinesin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables kinesin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor complex adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in anterograde axonal protein transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in axon development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in axon regeneration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
C-Jun-amino-terminal kinase-interacting protein 3
Names
C-jun-amino-terminal kinase interacting protein 3
JNK MAP kinase scaffold protein 3
JNK-interacting protein 3
JNK/SAPK-associated protein-1
JNK/stress-activated protein kinase-associated protein 1
homolog of Drosophila Sunday driver 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040439.2NP_001035529.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AB028989, AC012180, AL031710, BC087861, BM791368, BY795428, CA776361, CN361410, CN405914, CN405915
    Consensus CDS
    CCDS45379.1
    UniProtKB/Swiss-Prot
    Q9UPT6
    UniProtKB/TrEMBL
    E9PFH7
    Related
    ENSP00000348290.5, ENST00000356010.9
    Conserved Domains (5) summary
    pfam05887
    Location:843965
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    pfam07926
    Location:61167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam15035
    Location:441554
    Rootletin; Ciliary rootlet component, centrosome cohesion
    pfam16471
    Location:410478
    JIP_LZII; JNK-interacting protein leucine zipper II
  2. NM_001318852.2NP_001305781.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1 by a single amino acid.
    Source sequence(s)
    AC012180, AL031710, AL031717
    Consensus CDS
    CCDS81929.1
    UniProtKB/Swiss-Prot
    Q9UPT6
    UniProtKB/TrEMBL
    A0A087WYG2, B7ZMF3
    Related
    ENSP00000481780.1, ENST00000610761.2
    Conserved Domains (5) summary
    pfam05887
    Location:850972
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    pfam07926
    Location:61167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam15035
    Location:448561
    Rootletin; Ciliary rootlet component, centrosome cohesion
    pfam16471
    Location:417485
    JIP_LZII; JNK-interacting protein leucine zipper II
  3. NM_015133.5NP_055948.2  C-Jun-amino-terminal kinase-interacting protein 3 isoform 1

    See identical proteins and their annotated locations for NP_055948.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC012180, AI291346, BC137124, BQ706804, DA135446
    Consensus CDS
    CCDS10442.2
    UniProtKB/Swiss-Prot
    Q9UPT6
    Related
    ENSP00000250894.4, ENST00000250894.8
    Conserved Domains (4) summary
    pfam05887
    Location:849971
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:416484
    JIP_LZII; JNK-interacting protein leucine zipper II
    cl25732
    Location:427553
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    1706183..1770351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450201.1XP_024305969.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform X1

    Conserved Domains (4) summary
    pfam05887
    Location:858980
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:425493
    JIP_LZII; JNK-interacting protein leucine zipper II
    cl25732
    Location:436562
    SMC_N; RecF/RecN/SMC N terminal domain
  2. XM_011522429.2XP_011520731.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform X9

    Related
    ENSP00000501096.1, ENST00000673691.1
    Conserved Domains (5) summary
    pfam05887
    Location:858980
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    pfam07926
    Location:61167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam15035
    Location:456569
    Rootletin; Ciliary rootlet component, centrosome cohesion
    pfam16471
    Location:425493
    JIP_LZII; JNK-interacting protein leucine zipper II
  3. XM_024450205.1XP_024305973.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform X5

    Conserved Domains (4) summary
    pfam05887
    Location:849971
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:425493
    JIP_LZII; JNK-interacting protein leucine zipper II
    cl25732
    Location:391569
    SMC_N; RecF/RecN/SMC N terminal domain
  4. XM_024450202.1XP_024305970.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform X2

    Conserved Domains (4) summary
    pfam05887
    Location:852974
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:419487
    JIP_LZII; JNK-interacting protein leucine zipper II
    cl25732
    Location:400575
    SMC_N; RecF/RecN/SMC N terminal domain
  5. XM_011522430.2XP_011520732.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform X10

    Conserved Domains (5) summary
    pfam05887
    Location:852974
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    pfam07926
    Location:61167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam15035
    Location:450563
    Rootletin; Ciliary rootlet component, centrosome cohesion
    pfam16471
    Location:419487
    JIP_LZII; JNK-interacting protein leucine zipper II
  6. XM_024450207.1XP_024305975.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform X7

    Conserved Domains (4) summary
    pfam05887
    Location:843965
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:419487
    JIP_LZII; JNK-interacting protein leucine zipper II
    cl25732
    Location:389564
    SMC_N; RecF/RecN/SMC N terminal domain
  7. XM_024450203.1XP_024305971.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform X3

    Conserved Domains (4) summary
    pfam05887
    Location:850972
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:417485
    JIP_LZII; JNK-interacting protein leucine zipper II
    cl25732
    Location:428554
    SMC_N; RecF/RecN/SMC N terminal domain
  8. XM_024450208.1XP_024305976.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform X8

    Conserved Domains (4) summary
    pfam05887
    Location:841963
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:417485
    JIP_LZII; JNK-interacting protein leucine zipper II
    cl25732
    Location:49561
    SMC_N; RecF/RecN/SMC N terminal domain
  9. XM_024450206.1XP_024305974.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform X6

    Conserved Domains (4) summary
    pfam05887
    Location:844966
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:411479
    JIP_LZII; JNK-interacting protein leucine zipper II
    cl25732
    Location:392567
    SMC_N; RecF/RecN/SMC N terminal domain
  10. XM_005255190.2XP_005255247.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform X11

    Conserved Domains (5) summary
    pfam05887
    Location:835957
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    pfam07926
    Location:61167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:411479
    JIP_LZII; JNK-interacting protein leucine zipper II
    cl21478
    Location:457507
    ATP-synt_B; ATP synthase B/B' CF(0)
  11. XM_024450204.1XP_024305972.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform X4

    Conserved Domains (4) summary
    pfam05887
    Location:849971
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:416484
    JIP_LZII; JNK-interacting protein leucine zipper II
    cl25732
    Location:427553
    SMC_N; RecF/RecN/SMC N terminal domain
  12. XM_024450211.1XP_024305979.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform X14

    Conserved Domains (3) summary
    pfam05887
    Location:596718
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    pfam16471
    Location:163231
    JIP_LZII; JNK-interacting protein leucine zipper II
    cl25549
    Location:201307
    ARGLU; Arginine and glutamate-rich 1
  13. XM_024450209.1XP_024305977.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform X12

    Conserved Domains (3) summary
    pfam05887
    Location:692814
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    pfam16471
    Location:259327
    JIP_LZII; JNK-interacting protein leucine zipper II
    cl25549
    Location:297403
    ARGLU; Arginine and glutamate-rich 1
  14. XM_024450210.1XP_024305978.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform X13

    Conserved Domains (3) summary
    pfam05887
    Location:690812
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    pfam16471
    Location:257325
    JIP_LZII; JNK-interacting protein leucine zipper II
    cl25549
    Location:295401
    ARGLU; Arginine and glutamate-rich 1

RNA

  1. XR_001751875.1 RNA Sequence

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