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P2rx2 purinergic receptor P2X, ligand-gated ion channel, 2 [ Mus musculus (house mouse) ]

Gene ID: 231602, updated on 27-Nov-2024

Summary

Official Symbol
P2rx2provided by MGI
Official Full Name
purinergic receptor P2X, ligand-gated ion channel, 2provided by MGI
Primary source
MGI:MGI:2665170
See related
Ensembl:ENSMUSG00000029503 AllianceGenome:MGI:2665170
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P2x2; P2X2a
Summary
Enables extracellularly ATP-gated monoatomic cation channel activity. Involved in sensory perception of sound. Acts upstream of or within several processes, including neuromuscular synaptic transmission; skeletal muscle fiber development; and smooth muscle contraction. Located in plasma membrane. Is active in neuronal dense core vesicle. Is expressed in facial ganglion; heart; medulla oblongata basal plate mantle layer; and vagus ganglion. Used to study autosomal dominant nonsyndromic deafness 41. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 41. Orthologous to human P2RX2 (purinergic receptor P2X 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 29.2), genital fat pad adult (RPKM 19.6) and 5 other tissues See more
Orthologs
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Genomic context

See P2rx2 in Genome Data Viewer
Location:
5 F; 5 53.49 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (110487678..110491186, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (110339812..110343320, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6363 Neighboring gene peroxisomal membrane protein 2 Neighboring gene polymerase (DNA directed), epsilon Neighboring gene predicted gene, 26277 Neighboring gene leucine rich colipase-like 1 Neighboring gene fibrosin-like 1 Neighboring gene STARR-seq mESC enhancer starr_13955 Neighboring gene STARR-positive B cell enhancer ABC_E3598

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Clone Names

  • MGC129148, MGC129149

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 
enables cadmium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables cobalt ion binding ISO
Inferred from Sequence Orthology
more info
 
enables copper ion binding ISO
Inferred from Sequence Orthology
more info
 
enables extracellularly ATP-gated monoatomic cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables extracellularly ATP-gated monoatomic cation channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables extracellularly ATP-gated monoatomic cation channel activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables extracellularly ATP-gated monoatomic cation channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables extracellularly ATP-gated monoatomic cation channel activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ligand-gated monoatomic ion channel activity ISO
Inferred from Sequence Orthology
more info
 
enables mercury ion binding ISO
Inferred from Sequence Orthology
more info
 
enables nickel cation binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables purinergic nucleotide receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables purinergic nucleotide receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables suramin binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within behavioral response to pain IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within behavioral response to pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within detection of hypoxic conditions in blood by carotid body chemoreceptor signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neuromuscular junction development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuromuscular synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuronal action potential ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peristalsis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of presynaptic cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to ATP IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within response to ATP IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to carbohydrate IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to ischemia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
involved_in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sensory perception of sound ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sensory perception of taste IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within skeletal muscle fiber development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within urinary bladder smooth muscle contraction IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within urinary bladder smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuronal dense core vesicle EXP
Inferred from Experiment
more info
PubMed 
is_active_in neuronal dense core vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164833.1NP_001158305.1  P2X purinoceptor 2 isoform b

    See identical proteins and their annotated locations for NP_001158305.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment in the 3' coding region compared to variant 1. The encoded protein (isoform b) is shorter than isoform a.
    Source sequence(s)
    AB094664, BY236715
    Consensus CDS
    CCDS51608.1
    UniProtKB/Swiss-Prot
    Q8K3P1
    Related
    ENSMUSP00000108097.4, ENSMUST00000112478.8
    Conserved Domains (1) summary
    TIGR00863
    Location:14380
    P2X; cation transporter protein
  2. NM_001164834.1NP_001158306.1  P2X purinoceptor 2 isoform c

    See identical proteins and their annotated locations for NP_001158306.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame segment in the 3' coding region compared to variant 1. The encoded protein (isoform e) is shorter than isoform a.
    Source sequence(s)
    AB094663, BY236715
    Consensus CDS
    CCDS80362.1
    UniProtKB/Swiss-Prot
    Q8K3P1
    Related
    ENSMUSP00000143554.2, ENSMUST00000200037.5
    Conserved Domains (1) summary
    TIGR00863
    Location:14380
    P2X; cation transporter protein
  3. NM_001310700.1NP_001297629.1  P2X purinoceptor 2 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (d) is longer than isoform 1.
    Source sequence(s)
    AK141196, AK158334, BY236715, BY595018
    Consensus CDS
    CCDS80363.1
    UniProtKB/Swiss-Prot
    Q8K3P1
    Related
    ENSMUSP00000054233.11, ENSMUST00000058016.16
    Conserved Domains (2) summary
    TIGR00863
    Location:14392
    P2X; cation transporter protein
    pfam06409
    Location:399458
    NPIP; Nuclear pore complex interacting protein (NPIP)
  4. NM_001310701.1NP_001297630.1  P2X purinoceptor 2 isoform e

    See identical proteins and their annotated locations for NP_001297630.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (e) has a shorter N-terminus than isoform a.
    Source sequence(s)
    AC123699
    Consensus CDS
    CCDS80361.1
    UniProtKB/Swiss-Prot
    Q8K3P1
    Related
    ENSMUSP00000142567.2, ENSMUST00000200214.2
    Conserved Domains (1) summary
    cl02993
    Location:1293
    P2X_receptor; ATP P2X receptor
  5. NM_153400.4NP_700449.2  P2X purinoceptor 2 isoform a

    See identical proteins and their annotated locations for NP_700449.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AB094663, AB094664, AK141196, BY236715
    Consensus CDS
    CCDS51607.1
    UniProtKB/Swiss-Prot
    Q3KP15, Q3TYV0, Q812E6, Q812E7, Q8K3P1
    Related
    ENSMUSP00000143047.2, ENSMUST00000195985.5
    Conserved Domains (2) summary
    TIGR00863
    Location:14380
    P2X; cation transporter protein
    pfam06409
    Location:387446
    NPIP; Nuclear pore complex interacting protein (NPIP)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    110487678..110491186 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534921.4XP_006534984.1  P2X purinoceptor 2 isoform X2

    See identical proteins and their annotated locations for XP_006534984.1

    Conserved Domains (1) summary
    cl02993
    Location:5299
    P2X_receptor; ATP P2X receptor
  2. XM_006534920.4XP_006534983.1  P2X purinoceptor 2 isoform X1

    Conserved Domains (1) summary
    TIGR00863
    Location:14392
    P2X; cation transporter protein
  3. XM_011249448.2XP_011247750.1  P2X purinoceptor 2 isoform X3

    See identical proteins and their annotated locations for XP_011247750.1

    UniProtKB/Swiss-Prot
    Q8K3P1
    Conserved Domains (1) summary
    cl02993
    Location:1293
    P2X_receptor; ATP P2X receptor
  4. XM_011249447.3XP_011247749.1  P2X purinoceptor 2 isoform X2

    See identical proteins and their annotated locations for XP_011247749.1

    Conserved Domains (1) summary
    cl02993
    Location:5299
    P2X_receptor; ATP P2X receptor