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P2rx2 purinergic receptor P2X, ligand-gated ion channel, 2 [ Mus musculus (house mouse) ]

Gene ID: 231602, updated on 16-Mar-2019

Summary

Official Symbol
P2rx2provided by MGI
Official Full Name
purinergic receptor P2X, ligand-gated ion channel, 2provided by MGI
Primary source
MGI:MGI:2665170
See related
Ensembl:ENSMUSG00000029503
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P2x2; P2X2a
Expression
Biased expression in testis adult (RPKM 29.2), genital fat pad adult (RPKM 19.6) and 5 other tissues See more
Orthologs

Genomic context

See P2rx2 in Genome Data Viewer
Location:
5; 5 F
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (110339812..110343449, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (110768831..110772054, complement)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene peroxisomal membrane protein 2 Neighboring gene polymerase (DNA directed), epsilon Neighboring gene leucine rich colipase-like 1 Neighboring gene fibrosin-like 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Clone Names

  • MGC129148, MGC129149

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding ISO
Inferred from Sequence Orthology
more info
 
ATP-gated ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cadmium ion binding ISO
Inferred from Sequence Orthology
more info
 
cobalt ion binding ISO
Inferred from Sequence Orthology
more info
 
copper ion binding ISO
Inferred from Sequence Orthology
more info
 
drug binding ISO
Inferred from Sequence Orthology
more info
 
extracellularly ATP-gated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellularly ATP-gated cation channel activity IDA
Inferred from Direct Assay
more info
PubMed 
extracellularly ATP-gated cation channel activity IGI
Inferred from Genetic Interaction
more info
PubMed 
extracellularly ATP-gated cation channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
extracellularly ATP-gated cation channel activity ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
ion channel activity IEA
Inferred from Electronic Annotation
more info
 
ligand-gated ion channel activity ISO
Inferred from Sequence Orthology
more info
 
mercury ion binding ISO
Inferred from Sequence Orthology
more info
 
nickel cation binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
 
purinergic nucleotide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
behavioral response to pain IGI
Inferred from Genetic Interaction
more info
PubMed 
behavioral response to pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
cation transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
detection of hypoxic conditions in blood by carotid body chemoreceptor signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion transport IEA
Inferred from Electronic Annotation
more info
 
neuromuscular junction development IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuromuscular synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuronal action potential ISO
Inferred from Sequence Orthology
more info
 
peristalsis IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein heterooligomerization ISO
Inferred from Sequence Orthology
more info
 
protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
regulation of presynaptic cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
regulation of synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
 
response to ATP IGI
Inferred from Genetic Interaction
more info
PubMed 
response to ATP IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to carbohydrate IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to ischemia ISO
Inferred from Sequence Orthology
more info
 
response to organic substance IMP
Inferred from Mutant Phenotype
more info
PubMed 
sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
sensory perception of sound ISO
Inferred from Sequence Orthology
more info
 
sensory perception of taste IGI
Inferred from Genetic Interaction
more info
PubMed 
skeletal muscle fiber development IMP
Inferred from Mutant Phenotype
more info
PubMed 
urinary bladder smooth muscle contraction IGI
Inferred from Genetic Interaction
more info
PubMed 
urinary bladder smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
dendritic spine ISO
Inferred from Sequence Orthology
more info
 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
terminal bouton ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164833.1NP_001158305.1  P2X purinoceptor 2 isoform b

    See identical proteins and their annotated locations for NP_001158305.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment in the 3' coding region compared to variant 1. The encoded protein (isoform b) is shorter than isoform a.
    Source sequence(s)
    AB094664, BY236715
    Consensus CDS
    CCDS51608.1
    UniProtKB/Swiss-Prot
    Q8K3P1
    Related
    ENSMUSP00000108097.3, ENSMUST00000112478.7
    Conserved Domains (1) summary
    TIGR00863
    Location:14380
    P2X; cation transporter protein
  2. NM_001164834.1NP_001158306.1  P2X purinoceptor 2 isoform c

    See identical proteins and their annotated locations for NP_001158306.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame segment in the 3' coding region compared to variant 1. The encoded protein (isoform e) is shorter than isoform a.
    Source sequence(s)
    AB094663, BY236715
    Consensus CDS
    CCDS80362.1
    UniProtKB/Swiss-Prot
    Q8K3P1
    Related
    ENSMUSP00000143554.1, ENSMUST00000200037.4
    Conserved Domains (1) summary
    TIGR00863
    Location:14380
    P2X; cation transporter protein
  3. NM_001310700.1NP_001297629.1  P2X purinoceptor 2 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (d) is longer than isoform 1.
    Source sequence(s)
    AK141196, AK158334, BY236715, BY595018
    Consensus CDS
    CCDS80363.1
    UniProtKB/Swiss-Prot
    Q8K3P1
    Related
    ENSMUSP00000054233.10, ENSMUST00000058016.15
    Conserved Domains (2) summary
    TIGR00863
    Location:14392
    P2X; cation transporter protein
    pfam06409
    Location:399458
    NPIP; Nuclear pore complex interacting protein (NPIP)
  4. NM_001310701.1NP_001297630.1  P2X purinoceptor 2 isoform e

    See identical proteins and their annotated locations for NP_001297630.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (e) has a shorter N-terminus than isoform a.
    Source sequence(s)
    AC123699
    Consensus CDS
    CCDS80361.1
    UniProtKB/Swiss-Prot
    Q8K3P1
    Related
    ENSMUSP00000142567.1, ENSMUST00000200214.1
    Conserved Domains (2) summary
    pfam06409
    Location:300359
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl02993
    Location:1293
    P2X_receptor; ATP P2X receptor
  5. NM_153400.4NP_700449.2  P2X purinoceptor 2 isoform a

    See identical proteins and their annotated locations for NP_700449.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AB094663, AB094664, AK141196, BY236715
    Consensus CDS
    CCDS51607.1
    UniProtKB/Swiss-Prot
    Q8K3P1
    Related
    ENSMUSP00000143047.1, ENSMUST00000195985.4
    Conserved Domains (2) summary
    TIGR00863
    Location:14380
    P2X; cation transporter protein
    pfam06409
    Location:387446
    NPIP; Nuclear pore complex interacting protein (NPIP)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

    Range
    110339812..110343449 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534921.3XP_006534984.1  P2X purinoceptor 2 isoform X2

    See identical proteins and their annotated locations for XP_006534984.1

    Conserved Domains (2) summary
    pfam06409
    Location:306365
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl02993
    Location:5299
    P2X_receptor; ATP P2X receptor
  2. XM_006534920.3XP_006534983.1  P2X purinoceptor 2 isoform X1

    Conserved Domains (1) summary
    TIGR00863
    Location:14392
    P2X; cation transporter protein
  3. XM_011249447.2XP_011247749.1  P2X purinoceptor 2 isoform X2

    See identical proteins and their annotated locations for XP_011247749.1

    Conserved Domains (2) summary
    pfam06409
    Location:306365
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl02993
    Location:5299
    P2X_receptor; ATP P2X receptor
  4. XM_011249448.2XP_011247750.1  P2X purinoceptor 2 isoform X3

    See identical proteins and their annotated locations for XP_011247750.1

    UniProtKB/Swiss-Prot
    Q8K3P1
    Conserved Domains (2) summary
    pfam06409
    Location:300359
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl02993
    Location:1293
    P2X_receptor; ATP P2X receptor
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