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Plac8 placenta-specific 8 [ Mus musculus (house mouse) ]

Gene ID: 231507, updated on 22-May-2022

Summary

Official Symbol
Plac8provided by MGI
Official Full Name
placenta-specific 8provided by MGI
Primary source
MGI:MGI:2445289
See related
Ensembl:ENSMUSG00000029322 AllianceGenome:MGI:2445289
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C15; D5Wsu111e
Summary
Enables chromatin binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including brown fat cell differentiation; defense response to bacterium; and response to cold. Predicted to be located in nucleus. Is expressed in several structures, including extraembryonic component; gut; liver lobe; oculomotor nerve; and prostate gland lobe. Orthologous to human PLAC8 (placenta associated 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in duodenum adult (RPKM 141.6), large intestine adult (RPKM 140.7) and 10 other tissues See more
Orthologs
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Genomic context

See Plac8 in Genome Data Viewer
Location:
5 E4; 5 48.49 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (100699455..100720119, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (100551589..100572253, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (100982752..101001224, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19620 Neighboring gene COP9 signalosome subunit 4 Neighboring gene coenzyme Q2 4-hydroxybenzoate polyprenyltransferase Neighboring gene heparanase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within brown fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within response to cold IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
placenta-specific gene 8 protein
Names
onzin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370754.1NP_001357683.1  placenta-specific gene 8 protein

    Status: VALIDATED

    Source sequence(s)
    AC109196
    Consensus CDS
    CCDS19464.1
    Related
    ENSMUSP00000108531.2, ENSMUST00000112910.2
    Conserved Domains (1) summary
    TIGR01571
    Location:21105
    A_thal_Cys_rich; uncharacterized Cys-rich domain
  2. NM_139198.3NP_631937.1  placenta-specific gene 8 protein

    See identical proteins and their annotated locations for NP_631937.1

    Status: VALIDATED

    Source sequence(s)
    AC109196
    Consensus CDS
    CCDS19464.1
    UniProtKB/Swiss-Prot
    Q9JI48
    Related
    ENSMUSP00000031264.6, ENSMUST00000031264.12
    Conserved Domains (1) summary
    TIGR01571
    Location:21105
    A_thal_Cys_rich; uncharacterized Cys-rich domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    100699455..100720119 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254403.1XP_030110263.1  placenta-specific gene 8 protein isoform X2

  2. XM_017320850.2XP_017176339.1  placenta-specific gene 8 protein isoform X1

  3. XM_030254402.2XP_030110262.1  placenta-specific gene 8 protein isoform X1

  4. XM_017320849.3XP_017176338.1  placenta-specific gene 8 protein isoform X1