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NACAD NAC alpha domain containing [ Homo sapiens (human) ]

Gene ID: 23148, updated on 7-Jul-2021

Summary

Official Symbol
NACADprovided by HGNC
Official Full Name
NAC alpha domain containingprovided by HGNC
Primary source
HGNC:HGNC:22196
See related
Ensembl:ENSG00000136274 MIM:619419
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in brain (RPKM 25.2), ovary (RPKM 5.5) and 11 other tissues See more
Orthologs
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Genomic context

See NACAD in Genome Data Viewer
Location:
7p13
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (45080432..45089452, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (45120036..45128568, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723334 Neighboring gene small nucleolar RNA host gene 15 Neighboring gene small nucleolar RNA, H/ACA box 9 Neighboring gene CCM2 scaffold protein Neighboring gene transforming growth factor beta regulator 4 Neighboring gene small nucleolar RNA, H/ACA box 5A Neighboring gene small nucleolar RNA, H/ACA box 5C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0363

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of nascent polypeptide-associated complex IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
NAC-alpha domain-containing protein 1
NP_001139806.1
XP_006715737.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146334.2NP_001139806.1  NAC-alpha domain-containing protein 1

    See identical proteins and their annotated locations for NP_001139806.1

    Status: VALIDATED

    Source sequence(s)
    AB002361, AC013416, BM680676, BM728120, EG328798
    Consensus CDS
    CCDS47582.1
    UniProtKB/Swiss-Prot
    O15069
    Related
    ENSP00000420477.2, ENST00000490531.3
    Conserved Domains (3) summary
    COG1308
    Location:14151562
    EGD2; Transcription factor homologous to NACalpha-BTF3 [Transcription]
    cd14416
    Location:15191562
    UBA_NACAD; UBA-like domain found in nascent polypeptide-associated complex subunit alpha domain-containing protein 1 (NACAD)
    pfam01849
    Location:14161469
    NAC; NAC domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    45080432..45089452 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715674.3XP_006715737.1  NAC-alpha domain-containing protein 1 isoform X1

    Conserved Domains (3) summary
    COG1308
    Location:12021349
    EGD2; Transcription factor homologous to NACalpha-BTF3 [Transcription]
    cd14416
    Location:13061349
    UBA_NACAD; UBA-like domain found in nascent polypeptide-associated complex subunit alpha domain-containing protein 1 (NACAD)
    pfam01849
    Location:12031256
    NAC; NAC domain

RNA

  1. XR_002956415.1 RNA Sequence

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