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Cnot6l CCR4-NOT transcription complex, subunit 6-like [ Mus musculus (house mouse) ]

Gene ID: 231464, updated on 5-Jan-2023

Summary

Official Symbol
Cnot6lprovided by MGI
Official Full Name
CCR4-NOT transcription complex, subunit 6-likeprovided by MGI
Primary source
MGI:MGI:2443154
See related
Ensembl:ENSMUSG00000034724 AllianceGenome:MGI:2443154
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4932442K20Rik
Summary
Enables poly(A)-specific ribonuclease activity. Acts upstream of or within nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay and positive regulation of cell population proliferation. Located in cytoplasm. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and white fat. Orthologous to human CNOT6L (CCR4-NOT transcription complex subunit 6 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 4.5), bladder adult (RPKM 3.7) and 27 other tissues See more
Orthologs
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Genomic context

See Cnot6l in Genome Data Viewer
Location:
5; 5 E3
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (96218192..96312044, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (96070333..96164198, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene chemokine (C-X-C motif) ligand 13 Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene mitochondrial ribosomal protein L1 Neighboring gene Fraser extracellular matrix complex subunit 1 Neighboring gene predicted gene, 33050

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC29037, DKFZp434K098

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables poly(A)-specific ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables poly(A)-specific ribonuclease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of CCR4-NOT complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of CCR4-NOT complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
CCR4-NOT transcription complex subunit 6-like
NP_001272440.1
NP_001272443.1
NP_659159.1
NP_849185.2
XP_006534933.1
XP_006534934.1
XP_006534935.1
XP_030110258.1
XP_030110259.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285511.1NP_001272440.1  CCR4-NOT transcription complex subunit 6-like isoform 1

    See identical proteins and their annotated locations for NP_001272440.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 2. Variants 1 and 3 encode the same isoform (1), which is shorter and has a distinct N-terminus, compared to isoform 2.
    Source sequence(s)
    AC129600, AK030112, AK151728
    Consensus CDS
    CCDS19448.1
    UniProtKB/Swiss-Prot
    Q8VEG6
    UniProtKB/TrEMBL
    A0A6P7R0V4
    Conserved Domains (3) summary
    cd10312
    Location:186533
    Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
    COG4886
    Location:52178
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:3352
    LRR_1; leucine-rich repeat [structural motif]
  2. NM_001285514.1NP_001272443.1  CCR4-NOT transcription complex subunit 6-like isoform 3

    See identical proteins and their annotated locations for NP_001272443.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' coding region and initiates translation at a downstream start codon, compared to variant 2. It encodes isoform 3, which is shorter at the N-terminus, compared to isoform 2.
    Source sequence(s)
    AC129600, AK030112, AK151728
    UniProtKB/Swiss-Prot
    Q8VEG6
    UniProtKB/TrEMBL
    A0A6P7QWS3
    Conserved Domains (2) summary
    cd10312
    Location:91438
    Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
    COG4886
    Location:383
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
  3. NM_144910.2NP_659159.1  CCR4-NOT transcription complex subunit 6-like isoform 1

    See identical proteins and their annotated locations for NP_659159.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 2. Variants 1 and 3 encode the same isoform (1), which is shorter and has a distinct N-terminus, compared to isoform 2.
    Source sequence(s)
    AC129600, AK030112, AK151728, BC018506, CF173938
    Consensus CDS
    CCDS19448.1
    UniProtKB/Swiss-Prot
    Q8VEG6
    UniProtKB/TrEMBL
    A0A6P7R0V4
    Related
    ENSMUSP00000119415.2, ENSMUST00000155901.8
    Conserved Domains (3) summary
    cd10312
    Location:186533
    Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
    COG4886
    Location:52178
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:3352
    LRR_1; leucine-rich repeat [structural motif]
  4. NM_178854.4NP_849185.2  CCR4-NOT transcription complex subunit 6-like isoform 2

    See identical proteins and their annotated locations for NP_849185.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (2).
    Source sequence(s)
    AC129600, AK030112, AK151728
    Consensus CDS
    CCDS51566.1
    UniProtKB/Swiss-Prot
    Q8C0P4, Q8VEG6
    UniProtKB/TrEMBL
    A0A6P5PNY1
    Related
    ENSMUSP00000108629.3, ENSMUST00000113005.9
    Conserved Domains (3) summary
    cd10312
    Location:191538
    Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
    COG4886
    Location:57183
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:3857
    LRR_1; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    96218192..96312044 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534870.5XP_006534933.1  CCR4-NOT transcription complex subunit 6-like isoform X1

    See identical proteins and their annotated locations for XP_006534933.1

    UniProtKB/Swiss-Prot
    Q8VEG6
    UniProtKB/TrEMBL
    A0A6P7R0V4
    Conserved Domains (3) summary
    cd10312
    Location:186533
    Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
    COG4886
    Location:52178
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:3352
    LRR_1; leucine-rich repeat [structural motif]
  2. XM_030254398.1XP_030110258.1  CCR4-NOT transcription complex subunit 6-like isoform X2

    UniProtKB/TrEMBL
    A0A6P7QWS3
    Conserved Domains (2) summary
    cd10312
    Location:91438
    Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
    COG4886
    Location:383
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
  3. XM_006534871.3XP_006534934.1  CCR4-NOT transcription complex subunit 6-like isoform X1

    See identical proteins and their annotated locations for XP_006534934.1

    UniProtKB/Swiss-Prot
    Q8VEG6
    UniProtKB/TrEMBL
    A0A6P7R0V4
    Conserved Domains (3) summary
    cd10312
    Location:186533
    Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
    COG4886
    Location:52178
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:3352
    LRR_1; leucine-rich repeat [structural motif]
  4. XM_030254399.2XP_030110259.1  CCR4-NOT transcription complex subunit 6-like isoform X2

    UniProtKB/TrEMBL
    A0A6P7QWS3
    Conserved Domains (2) summary
    cd10312
    Location:91438
    Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
    COG4886
    Location:383
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
  5. XM_006534872.4XP_006534935.1  CCR4-NOT transcription complex subunit 6-like isoform X3

    Conserved Domains (1) summary
    cd10312
    Location:50397
    Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like