Format

Send to:

Choose Destination

SMC5 structural maintenance of chromosomes 5 [ Homo sapiens (human) ]

Gene ID: 23137, updated on 13-Mar-2020

Summary

Official Symbol
SMC5provided by HGNC
Official Full Name
structural maintenance of chromosomes 5provided by HGNC
Primary source
HGNC:HGNC:20465
See related
Ensembl:ENSG00000198887 MIM:609386
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SMC5L1
Expression
Ubiquitous expression in ovary (RPKM 12.4), lymph node (RPKM 10.1) and 25 other tissues See more
Orthologs

Genomic context

See SMC5 in Genome Data Viewer
Location:
9q21.12
Exon count:
27
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (70258962..70354873)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (72873878..72969789)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene MAM domain containing 2 Neighboring gene RNA, U2 small nuclear 5, pseudogene Neighboring gene SMC5 antisense RNA 1 (head to head) Neighboring gene ribosomal protein L24 pseudogene 8 Neighboring gene Sharpr-MPRA regulatory region 12362 Neighboring gene Kruppel like factor 9 Neighboring gene KLF9 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0594

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
PML body IDA
Inferred from Direct Assay
more info
PubMed 
Smc5-Smc6 complex IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IDA
Inferred from Direct Assay
more info
 
chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
interchromatin granule IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
sex chromosome ISS
Inferred from Sequence or Structural Similarity
more info
 
site of double-strand break IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
structural maintenance of chromosomes protein 5
Names
SMC protein 5
SMC-5
SMC5 structural maintenance of chromosomes 5-like 1
hSMC5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015110.4NP_055925.2  structural maintenance of chromosomes protein 5

    See identical proteins and their annotated locations for NP_055925.2

    Status: VALIDATED

    Source sequence(s)
    AA709087, AB011166, BC038225, DB220819, DB318469
    Consensus CDS
    CCDS6632.1
    UniProtKB/Swiss-Prot
    Q8IY18
    Related
    ENSP00000354957.5, ENST00000361138.7
    Conserved Domains (2) summary
    cd03277
    Location:9751077
    ABC_SMC5_euk; ATP-binding cassette domain of eukaryotic SMC5 proteins
    COG1196
    Location:531055
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    70258962..70354873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014509.2XP_016869998.1  structural maintenance of chromosomes protein 5 isoform X6

  2. XM_005251837.2XP_005251894.1  structural maintenance of chromosomes protein 5 isoform X1

    Conserved Domains (2) summary
    cd03277
    Location:9601062
    ABC_SMC5_euk; ATP-binding cassette domain of eukaryotic SMC5 proteins
    COG1196
    Location:531040
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  3. XM_005251839.2XP_005251896.1  structural maintenance of chromosomes protein 5 isoform X4

    Conserved Domains (2) summary
    cd03277
    Location:9371039
    ABC_SMC5_euk; ATP-binding cassette domain of eukaryotic SMC5 proteins
    COG1196
    Location:531017
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  4. XM_005251838.2XP_005251895.1  structural maintenance of chromosomes protein 5 isoform X2

    Conserved Domains (3) summary
    cd03277
    Location:9511053
    ABC_SMC5_euk; ATP-binding cassette domain of eukaryotic SMC5 proteins
    COG1196
    Location:531031
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl07863
    Location:286364
    Phasin; Poly(hydroxyalcanoate) granule associated protein (phasin)
  5. XM_017014507.1XP_016869996.1  structural maintenance of chromosomes protein 5 isoform X3

  6. XM_017014508.1XP_016869997.1  structural maintenance of chromosomes protein 5 isoform X5

  7. XM_017014510.2XP_016869999.1  structural maintenance of chromosomes protein 5 isoform X7

RNA

  1. XR_001746256.1 RNA Sequence

Support Center