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Ppat phosphoribosyl pyrophosphate amidotransferase [ Mus musculus (house mouse) ]

Gene ID: 231327, updated on 12-May-2024

Summary

Official Symbol
Ppatprovided by MGI
Official Full Name
phosphoribosyl pyrophosphate amidotransferaseprovided by MGI
Primary source
MGI:MGI:2387203
See related
Ensembl:ENSMUSG00000029246 AllianceGenome:MGI:2387203
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GPAT; 5730454C12Rik
Summary
Enables amidophosphoribosyltransferase activity. Involved in purine ribonucleoside monophosphate biosynthetic process. Is expressed in several structures, including alimentary system; brain; liver; respiratory system; and urinary system. Orthologous to human PPAT (phosphoribosyl pyrophosphate amidotransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 11.6), liver E14.5 (RPKM 9.6) and 26 other tissues See more
Orthologs
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Genomic context

See Ppat in Genome Data Viewer
Location:
5 C3.3; 5 41.45 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (77061096..77099425, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (76913249..76951578, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene capping protein inhibiting regulator of actin Neighboring gene STARR-seq mESC enhancer starr_13451 Neighboring gene predicted gene, 52818 Neighboring gene STARR-seq mESC enhancer starr_13452 Neighboring gene aminoadipate-semialdehyde dehydrogenase Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase Neighboring gene predicted gene, 54291 Neighboring gene signal recognition particle 72 Neighboring gene ADP-ribosylation factor-like 9

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (2) 
  • Targeted (1) 

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC38417

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables amidophosphoribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables amidophosphoribosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables amidophosphoribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
amidophosphoribosyltransferase
Names
ATase
glutamine phosphoribosylpyrophosphate amidotransferase
NP_742158.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172146.2NP_742158.1  amidophosphoribosyltransferase

    See identical proteins and their annotated locations for NP_742158.1

    Status: VALIDATED

    Source sequence(s)
    AK147750, AK148034, AK159859, AK164506, BB647933
    Consensus CDS
    CCDS51527.1
    UniProtKB/Swiss-Prot
    Q3TKC5, Q3TUW2, Q3UGU3, Q8CIH9
    UniProtKB/TrEMBL
    Q3UGA8
    Related
    ENSMUSP00000120632.2, ENSMUST00000140076.2
    Conserved Domains (3) summary
    cd06223
    Location:306442
    PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain
    COG0034
    Location:8515
    PurF; Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]
    cd00715
    Location:12295
    GPATase_N; Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    77061096..77099425 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)