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Ppat phosphoribosyl pyrophosphate amidotransferase [ Mus musculus (house mouse) ]

Gene ID: 231327, updated on 12-Aug-2019

Summary

Official Symbol
Ppatprovided by MGI
Official Full Name
phosphoribosyl pyrophosphate amidotransferaseprovided by MGI
Primary source
MGI:MGI:2387203
See related
Ensembl:ENSMUSG00000029246
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C79945; AA408689; AA675351; AI507113; 5730454C12Rik
Expression
Ubiquitous expression in liver E14 (RPKM 11.6), liver E14.5 (RPKM 9.6) and 26 other tissues See more
Orthologs

Genomic context

See Ppat in Genome Data Viewer
Location:
5; 5 C3.3
Exon count:
11
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (76913249..76951578, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (77342274..77380603, complement)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C530008M17 gene Neighboring gene uncharacterized LOC115490193 Neighboring gene aminoadipate-semialdehyde dehydrogenase Neighboring gene uncharacterized LOC115486295 Neighboring gene predicted gene, 42102 Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase Neighboring gene RIKEN cDNA 1700112J05 gene Neighboring gene signal recognition particle 72 Neighboring gene ADP-ribosylation factor-like 9

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 

Pathways from BioSystems

General gene information

Markers

Homology

Clone Names

  • MGC38417

Gene Ontology Provided by MGI

Function Evidence Code Pubs
amidophosphoribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
glutamine catabolic process ISO
Inferred from Sequence Orthology
more info
 
protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
purine ribonucleoside monophosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
ribose phosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
amidophosphoribosyltransferase
NP_742158.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172146.2NP_742158.1  amidophosphoribosyltransferase

    See identical proteins and their annotated locations for NP_742158.1

    Status: VALIDATED

    Source sequence(s)
    AK147750, AK148034, AK159859, AK164506, BB647933
    Consensus CDS
    CCDS51527.1
    UniProtKB/TrEMBL
    Q3TKC5, Q3UGA8, Q3UGU3, Q8CIH9
    Related
    ENSMUSP00000120632.1, ENSMUST00000140076.1
    Conserved Domains (3) summary
    cd06223
    Location:306442
    PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain
    COG0034
    Location:8515
    PurF; Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]
    cd00715
    Location:12295
    GPATase_N; Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p6 C57BL/6J

    Range
    76913249..76951578 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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