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Aasdh aminoadipate-semialdehyde dehydrogenase [ Mus musculus (house mouse) ]

Gene ID: 231326, updated on 21-Apr-2024

Summary

Official Symbol
Aasdhprovided by MGI
Official Full Name
aminoadipate-semialdehyde dehydrogenaseprovided by MGI
Primary source
MGI:MGI:2442517
See related
Ensembl:ENSMUSG00000055923 AllianceGenome:MGI:2442517
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
U26; Acsf4; A830035E16; A230062G08Rik
Summary
The gene product is a cytosolic enzyme involved in the production of alpha-aminoadipic acid from alpha-aminoadipic semialdehyde. It is postulated that this enzyme plays a role in lysine metabolism. There is currently debate regarding this enzyme's putative requirement of pyrroloquinoline quinine as an essential cofactor. A related pseudogene has been identified on chromosome 2. [provided by RefSeq, Jan 2010]
Expression
Ubiquitous expression in bladder adult (RPKM 4.3), CNS E14 (RPKM 3.1) and 28 other tissues See more
Orthologs
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Genomic context

Location:
5 C3.3; 5 41.45 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (77021506..77053376, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (76873659..76905529, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene capping protein inhibiting regulator of actin Neighboring gene predicted gene, 34369 Neighboring gene STARR-seq mESC enhancer starr_13449 Neighboring gene STARR-seq mESC enhancer starr_13451 Neighboring gene predicted gene, 52818 Neighboring gene STARR-seq mESC enhancer starr_13452 Neighboring gene phosphoribosyl pyrophosphate amidotransferase Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase Neighboring gene predicted gene, 54291

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
beta-alanine-activating enzyme
Names
2-aminoadipic 6-semialdehyde dehydrogenase
acyl-CoA synthetase family member 4
protein LYS2 homolog
putative aminoadipate-semialdehyde dehydrogenase
NP_001363933.1
NP_776126.1
XP_006534916.1
XP_006534917.1
XP_006534919.1
XP_006534920.1
XP_006534922.1
XP_006534923.1
XP_011247724.1
XP_011247725.1
XP_017176330.1
XP_030110250.1
XP_030110251.1
XP_030110252.1
XP_036020953.1
XP_036020954.1
XP_036020955.1
XP_036020956.1
XP_036020957.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001377004.1NP_001363933.1  beta-alanine-activating enzyme

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC114666, AC166328
    UniProtKB/Swiss-Prot
    Q3V3L2, Q505K4, Q80WC9, Q8BRP4
    Conserved Domains (4) summary
    COG1520
    Location:754986
    PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
    TIGR03300
    Location:9231094
    assembly_YfgL; outer membrane assembly lipoprotein YfgL
    cd17654
    Location:15532
    A_NRPS_acs4; acyl-CoA synthetase family member 4
    pfam00550
    Location:561628
    PP-binding; Phosphopantetheine attachment site
  2. NM_173765.4NP_776126.1  beta-alanine-activating enzyme

    See identical proteins and their annotated locations for NP_776126.1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC114666, AC166328
    Consensus CDS
    CCDS19366.1
    UniProtKB/Swiss-Prot
    Q3V3L2, Q505K4, Q80WC9, Q8BRP4
    Related
    ENSMUSP00000113792.2, ENSMUST00000120963.8
    Conserved Domains (4) summary
    COG1520
    Location:754986
    PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
    TIGR03300
    Location:9231094
    assembly_YfgL; outer membrane assembly lipoprotein YfgL
    cd17654
    Location:15532
    A_NRPS_acs4; acyl-CoA synthetase family member 4
    pfam00550
    Location:561628
    PP-binding; Phosphopantetheine attachment site

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    77021506..77053376 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534854.3XP_006534917.1  beta-alanine-activating enzyme isoform X2

    Conserved Domains (4) summary
    COG1520
    Location:7541051
    PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
    sd00039
    Location:815849
    7WD40; WD40 repeat [structural motif]
    cd17654
    Location:15532
    A_NRPS_acs4; acyl-CoA synthetase family member 4
    pfam00550
    Location:561628
    PP-binding; Phosphopantetheine attachment site
  2. XM_011249423.3XP_011247725.1  beta-alanine-activating enzyme isoform X4

    Conserved Domains (4) summary
    TIGR03300
    Location:730881
    assembly_YfgL; outer membrane assembly lipoprotein YfgL
    sd00039
    Location:816850
    7WD40; WD40 repeat [structural motif]
    cd17654
    Location:15532
    A_NRPS_acs4; acyl-CoA synthetase family member 4
    pfam00550
    Location:561628
    PP-binding; Phosphopantetheine attachment site
  3. XM_006534856.4XP_006534919.1  beta-alanine-activating enzyme isoform X5

    Conserved Domains (4) summary
    TIGR03300
    Location:730881
    assembly_YfgL; outer membrane assembly lipoprotein YfgL
    sd00039
    Location:816850
    7WD40; WD40 repeat [structural motif]
    cd17654
    Location:15532
    A_NRPS_acs4; acyl-CoA synthetase family member 4
    pfam00550
    Location:561628
    PP-binding; Phosphopantetheine attachment site
  4. XM_006534857.4XP_006534920.1  beta-alanine-activating enzyme isoform X6

    Conserved Domains (4) summary
    COG1520
    Location:592824
    PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
    TIGR03300
    Location:761932
    assembly_YfgL; outer membrane assembly lipoprotein YfgL
    cd17654
    Location:26370
    A_NRPS_acs4; acyl-CoA synthetase family member 4
    pfam00550
    Location:399448
    PP-binding; Phosphopantetheine attachment site
  5. XM_036165061.1XP_036020954.1  beta-alanine-activating enzyme isoform X8

    Conserved Domains (4) summary
    COG1520
    Location:569866
    PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
    sd00039
    Location:630664
    7WD40; WD40 repeat [structural motif]
    cd17654
    Location:34347
    A_NRPS_acs4; acyl-CoA synthetase family member 4
    pfam00550
    Location:376425
    PP-binding; Phosphopantetheine attachment site
  6. XM_030254392.1XP_030110252.1  beta-alanine-activating enzyme isoform X7

    Conserved Domains (4) summary
    COG1520
    Location:569801
    PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
    TIGR03300
    Location:738909
    assembly_YfgL; outer membrane assembly lipoprotein YfgL
    cd17654
    Location:34347
    A_NRPS_acs4; acyl-CoA synthetase family member 4
    pfam00550
    Location:376443
    PP-binding; Phosphopantetheine attachment site
  7. XM_006534853.3XP_006534916.1  beta-alanine-activating enzyme isoform X1

    See identical proteins and their annotated locations for XP_006534916.1

    UniProtKB/Swiss-Prot
    Q3V3L2, Q505K4, Q80WC9, Q8BRP4
    Related
    ENSMUSP00000069279.9, ENSMUST00000069709.15
    Conserved Domains (4) summary
    COG1520
    Location:754986
    PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
    TIGR03300
    Location:9231094
    assembly_YfgL; outer membrane assembly lipoprotein YfgL
    cd17654
    Location:15532
    A_NRPS_acs4; acyl-CoA synthetase family member 4
    pfam00550
    Location:561628
    PP-binding; Phosphopantetheine attachment site
  8. XM_011249422.2XP_011247724.1  beta-alanine-activating enzyme isoform X1

    See identical proteins and their annotated locations for XP_011247724.1

    UniProtKB/Swiss-Prot
    Q3V3L2, Q505K4, Q80WC9, Q8BRP4
    Conserved Domains (4) summary
    COG1520
    Location:754986
    PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
    TIGR03300
    Location:9231094
    assembly_YfgL; outer membrane assembly lipoprotein YfgL
    cd17654
    Location:15532
    A_NRPS_acs4; acyl-CoA synthetase family member 4
    pfam00550
    Location:561628
    PP-binding; Phosphopantetheine attachment site
  9. XM_036165060.1XP_036020953.1  beta-alanine-activating enzyme isoform X6

    Conserved Domains (4) summary
    COG1520
    Location:592824
    PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
    TIGR03300
    Location:761932
    assembly_YfgL; outer membrane assembly lipoprotein YfgL
    cd17654
    Location:26370
    A_NRPS_acs4; acyl-CoA synthetase family member 4
    pfam00550
    Location:399448
    PP-binding; Phosphopantetheine attachment site
  10. XM_030254390.1XP_030110250.1  beta-alanine-activating enzyme isoform X2

    Conserved Domains (4) summary
    COG1520
    Location:7541051
    PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
    sd00039
    Location:815849
    7WD40; WD40 repeat [structural motif]
    cd17654
    Location:15532
    A_NRPS_acs4; acyl-CoA synthetase family member 4
    pfam00550
    Location:561628
    PP-binding; Phosphopantetheine attachment site
  11. XM_036165063.1XP_036020956.1  beta-alanine-activating enzyme isoform X12

    Conserved Domains (3) summary
    COG1520
    Location:242474
    PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
    TIGR03300
    Location:411582
    assembly_YfgL; outer membrane assembly lipoprotein YfgL
    pfam00550
    Location:4998
    PP-binding; Phosphopantetheine attachment site
  12. XM_030254391.1XP_030110251.1  beta-alanine-activating enzyme isoform X6

    Conserved Domains (4) summary
    COG1520
    Location:592824
    PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
    TIGR03300
    Location:761932
    assembly_YfgL; outer membrane assembly lipoprotein YfgL
    cd17654
    Location:26370
    A_NRPS_acs4; acyl-CoA synthetase family member 4
    pfam00550
    Location:399448
    PP-binding; Phosphopantetheine attachment site
  13. XM_036165064.1XP_036020957.1  beta-alanine-activating enzyme isoform X12

    Conserved Domains (3) summary
    COG1520
    Location:242474
    PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
    TIGR03300
    Location:411582
    assembly_YfgL; outer membrane assembly lipoprotein YfgL
    pfam00550
    Location:4998
    PP-binding; Phosphopantetheine attachment site
  14. XM_006534860.4XP_006534923.1  beta-alanine-activating enzyme isoform X10

    Conserved Domains (4) summary
    COG1520
    Location:392624
    PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
    TIGR03300
    Location:561732
    assembly_YfgL; outer membrane assembly lipoprotein YfgL
    pfam00550
    Location:199266
    PP-binding; Phosphopantetheine attachment site
    cl17068
    Location:4170
    AFD_class_I; Adenylate forming domain, Class I superfamily
  15. XM_036165062.1XP_036020955.1  beta-alanine-activating enzyme isoform X11

    Conserved Domains (4) summary
    COG1520
    Location:392689
    PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
    sd00039
    Location:453487
    7WD40; WD40 repeat [structural motif]
    pfam00550
    Location:199248
    PP-binding; Phosphopantetheine attachment site
    cl17068
    Location:4170
    AFD_class_I; Adenylate forming domain, Class I superfamily
  16. XM_017320841.3XP_017176330.1  beta-alanine-activating enzyme isoform X3

    Conserved Domains (3) summary
    COG1520
    Location:754962
    PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
    cd17654
    Location:15532
    A_NRPS_acs4; acyl-CoA synthetase family member 4
    pfam00550
    Location:561628
    PP-binding; Phosphopantetheine attachment site
  17. XM_006534859.5XP_006534922.1  beta-alanine-activating enzyme isoform X9

    Conserved Domains (3) summary
    COG1520
    Location:592800
    PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
    cd17654
    Location:26370
    A_NRPS_acs4; acyl-CoA synthetase family member 4
    pfam00550
    Location:399466
    PP-binding; Phosphopantetheine attachment site

RNA

  1. XR_880391.3 RNA Sequence

  2. XR_880390.3 RNA Sequence

  3. XR_389268.4 RNA Sequence

  4. XR_004942502.1 RNA Sequence

  5. XR_004942498.1 RNA Sequence

    Related
    ENSMUST00000126741.8
  6. XR_004942501.1 RNA Sequence

  7. XR_004942499.1 RNA Sequence

  8. XR_001784673.2 RNA Sequence

  9. XR_004942500.1 RNA Sequence

  10. XR_389267.3 RNA Sequence