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RAD54L2 RAD54 like 2 [ Homo sapiens (human) ]

Gene ID: 23132, updated on 4-Feb-2024

Summary

Official Symbol
RAD54L2provided by HGNC
Official Full Name
RAD54 like 2provided by HGNC
Primary source
HGNC:HGNC:29123
See related
Ensembl:ENSG00000164080 MIM:620006; AllianceGenome:HGNC:29123
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARIP4; HSPC325; SRISNF2L
Summary
Predicted to enable ATP hydrolysis activity; protein kinase binding activity; and transcription coregulator activity. Predicted to be involved in DNA duplex unwinding. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in nuclear speck. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 3.3), spleen (RPKM 2.8) and 25 other tissues See more
Orthologs
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Genomic context

See RAD54L2 in Genome Data Viewer
Location:
3p21.2
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (51538719..51668660)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (51569157..51700178)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (51572735..51702676)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 15B Neighboring gene DDB1 and CUL4 associated factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14412 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19919 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14413 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14414 Neighboring gene uncharacterized LOC105377085 Neighboring gene Sharpr-MPRA regulatory region 10823 Neighboring gene Sharpr-MPRA regulatory region 62 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19920 Neighboring gene NANOG hESC enhancer GRCh37_chr3:51578193-51578834 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:51581873-51582372 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:51589128-51590066 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:51617110-51617895 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:51627487-51627690 Neighboring gene RNA, U6atac small nuclear 29, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:51696703-51697203 Neighboring gene uncharacterized LOC124906237 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14416 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:51712641-51713399 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14417 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:51721007-51721622 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:51724855-51725678 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:51725679-51726501 Neighboring gene testis expressed 264, ER-phagy receptor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:51737956-51738824 Neighboring gene RNA, 5S ribosomal pseudogene 132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:51750466-51751323 Neighboring gene glutamate metabotropic receptor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ21396, FLJ22400, KIAA0809

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent chromatin remodeler activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
helicase ARIP4
Names
AR interacting protein 4
RAD54-like protein 2
androgen receptor-interacting protein 4
NP_001309182.1
NP_001309185.1
NP_001374795.1
NP_001374796.1
NP_001374798.1
NP_055921.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001322253.2NP_001309182.1  helicase ARIP4 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC092037, AC099050, AC113933
    Consensus CDS
    CCDS33765.2
    UniProtKB/Swiss-Prot
    Q8TB57, Q9BV54, Q9Y4B4
    UniProtKB/TrEMBL
    H0Y760
    Conserved Domains (3) summary
    PHA03247
    Location:11061414
    PHA03247; large tegument protein UL36; Provisional
    COG0553
    Location:134907
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd18069
    Location:271547
    DEXHc_ARIP4; DEXH-box helicase domain of ARIP4
  2. NM_001322256.2NP_001309185.1  helicase ARIP4 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC092037, AC099050, AC113933
    Consensus CDS
    CCDS33765.2
    UniProtKB/Swiss-Prot
    Q8TB57, Q9BV54, Q9Y4B4
    UniProtKB/TrEMBL
    H0Y760
    Conserved Domains (3) summary
    PHA03247
    Location:11061414
    PHA03247; large tegument protein UL36; Provisional
    COG0553
    Location:134907
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd18069
    Location:271547
    DEXHc_ARIP4; DEXH-box helicase domain of ARIP4
  3. NM_001387866.1NP_001374795.1  helicase ARIP4 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC092037, AC099050, AC113933
    UniProtKB/TrEMBL
    H0Y760
    Conserved Domains (3) summary
    PHA03247
    Location:11041412
    PHA03247; large tegument protein UL36; Provisional
    COG0553
    Location:134905
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd18069
    Location:271547
    DEXHc_ARIP4; DEXH-box helicase domain of ARIP4
  4. NM_001387867.1NP_001374796.1  helicase ARIP4 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC092037, AC099050, AC113933
    UniProtKB/TrEMBL
    H0Y760
    Conserved Domains (3) summary
    PHA03247
    Location:11011409
    PHA03247; large tegument protein UL36; Provisional
    COG0553
    Location:134902
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd18069
    Location:271542
    DEXHc_ARIP4; DEXH-box helicase domain of ARIP4
  5. NM_001387869.1NP_001374798.1  helicase ARIP4 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC092037, AC099050, AC113933
    UniProtKB/TrEMBL
    H0Y760
    Related
    ENSP00000410283.1, ENST00000432863.1
    Conserved Domains (3) summary
    PHA03247
    Location:10541362
    PHA03247; large tegument protein UL36; Provisional
    COG0553
    Location:82855
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd18069
    Location:219495
    DEXHc_ARIP4; DEXH-box helicase domain of ARIP4
  6. NM_015106.4NP_055921.2  helicase ARIP4 isoform a

    See identical proteins and their annotated locations for NP_055921.2

    Status: VALIDATED

    Source sequence(s)
    AC092037, AC099050, AC113933
    Consensus CDS
    CCDS33765.2
    UniProtKB/Swiss-Prot
    Q8TB57, Q9BV54, Q9Y4B4
    UniProtKB/TrEMBL
    H0Y760
    Related
    ENSP00000507587.1, ENST00000684192.1
    Conserved Domains (3) summary
    PHA03247
    Location:11061414
    PHA03247; large tegument protein UL36; Provisional
    COG0553
    Location:134907
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd18069
    Location:271547
    DEXHc_ARIP4; DEXH-box helicase domain of ARIP4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    51538719..51668660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    51569157..51700178
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001322257.1: Suppressed sequence

    Description
    NM_001322257.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.