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POGZ pogo transposable element derived with ZNF domain [ Homo sapiens (human) ]

Gene ID: 23126, updated on 7-Oct-2018

Summary

Official Symbol
POGZprovided by HGNC
Official Full Name
pogo transposable element derived with ZNF domainprovided by HGNC
Primary source
HGNC:HGNC:18801
See related
Ensembl:ENSG00000143442 MIM:614787; Vega:OTTHUMG00000012499
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRD37; WHSUS; ZNF635; ZNF280E; ZNF635m
Summary
The protein encoded by this gene appears to be a zinc finger protein containing a transposase domain at the C-terminus. This protein was found to interact with the transcription factor SP1 in a yeast two-hybrid system. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Aug 2010]
Expression
Ubiquitous expression in ovary (RPKM 11.8), testis (RPKM 9.5) and 25 other tissues See more
Orthologs

Genomic context

See POGZ in Genome Data Viewer
Location:
1q21.3
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (151402724..151459465, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151375200..151445753, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene selenium binding protein 1 Neighboring gene proteasome subunit beta 4 Neighboring gene RNY4 pseudogene 25 Neighboring gene cingulin Neighboring gene tuftelin 1 Neighboring gene microRNA 554

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
White-sutton syndrome
MedGen: C4225351 OMIM: 616364 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2017-12-27)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated (2017-12-27)

ClinGen Genome Curation PagePubMed

NHGRI GWAS Catalog

Description
Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol The IN catalytic core domain has a higher binding affinity (Kd) for PSIP1 (LEDGF/p75) than the physiological binding partner, POGZ PubMed
gag-pol The HIV-1 IN interaction site on the PSIP1 (LEDGF/p75) integrase binding domain (IBD) overlaps with that of POGZ PubMed
gag-pol HIV-1 IN efficiently displaces POGZ from LEDGF/p75 PubMed
gag-pol A domesticated transposase, POGZ, carries a DDE domain (amino acids 1117-1323) and interacts with LEDGF/p75. PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0461, MGC71543

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell division IEA
Inferred from Electronic Annotation
more info
 
kinetochore assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
colocalizes_with histone methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
colocalizes_with nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
pogo transposable element with ZNF domain
Names
putative protein product of Nbla00003
zinc finger protein 280E
zinc finger protein 635

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046601.1 RefSeqGene

    Range
    5001..61742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001194937.1NP_001181866.1  pogo transposable element with ZNF domain isoform 4

    See identical proteins and their annotated locations for NP_001181866.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
    Source sequence(s)
    AB007930, AJ242979, AK300307, AL589764, BX537838, BX649163
    Consensus CDS
    CCDS53366.1
    UniProtKB/Swiss-Prot
    Q7Z3K3
    Related
    ENSP00000386836.1, OTTHUMP00000203655, ENST00000409503.5, OTTHUMT00000330643
    Conserved Domains (5) summary
    smart00674
    Location:10121073
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    sd00017
    Location:523544
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:487520
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl21549
    Location:11471271
    rve; Integrase core domain
    cl27427
    Location:404453
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
  2. NM_001194938.1NP_001181867.1  pogo transposable element with ZNF domain isoform 5

    See identical proteins and their annotated locations for NP_001181867.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an in-frame exon and uses an alternate in-frame splice site to variant 1. This results in a shorter protein (isoform 5), compared to isoform 1.
    Source sequence(s)
    AB007930, AJ242979, AK300307, AK302501, AL589764, BX537838, BX649163
    Consensus CDS
    CCDS53365.1
    UniProtKB/Swiss-Prot
    Q7Z3K3
    Related
    ENSP00000431259.1, OTTHUMP00000235067, ENST00000531094.5, OTTHUMT00000392975
    Conserved Domains (5) summary
    smart00674
    Location:9591020
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    sd00017
    Location:470491
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:434467
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl21549
    Location:10941218
    rve; Integrase core domain
    cl27427
    Location:351400
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
  3. NM_015100.3NP_055915.2  pogo transposable element with ZNF domain isoform 1

    See identical proteins and their annotated locations for NP_055915.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB007930, AJ242979, AL589764, BX537838, BX649163
    Consensus CDS
    CCDS997.1
    UniProtKB/Swiss-Prot
    Q7Z3K3
    Related
    ENSP00000271715.2, OTTHUMP00000014468, ENST00000271715.6, OTTHUMT00000034915
    Conserved Domains (6) summary
    smart00674
    Location:10211082
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    sd00017
    Location:532553
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:496529
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam09606
    Location:101357
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl21549
    Location:11561280
    rve; Integrase core domain
    cl27427
    Location:271462
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
  4. NM_145796.3NP_665739.3  pogo transposable element with ZNF domain isoform 3

    See identical proteins and their annotated locations for NP_665739.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two in-frame exons compared to variant 1. The resulting isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AB007930, AJ242979, AK300307, AL589764, BX537561, BX537838, BX649163
    Consensus CDS
    CCDS44222.2
    UniProtKB/Swiss-Prot
    Q7Z3K3
    Related
    ENSP00000357856.2, OTTHUMP00000014470, ENST00000368863.6, OTTHUMT00000034917
    Conserved Domains (5) summary
    smart00674
    Location:926987
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    sd00017
    Location:437458
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:401434
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl21549
    Location:10611185
    rve; Integrase core domain
    cl27427
    Location:180367
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
  5. NM_207171.2NP_997054.1  pogo transposable element with ZNF domain isoform 2

    See identical proteins and their annotated locations for NP_997054.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame exon compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB007930, AL589764, BX537561, BX649163
    Consensus CDS
    CCDS998.1
    UniProtKB/Swiss-Prot
    Q7Z3K3
    Related
    ENSP00000376484.1, OTTHUMP00000014469, ENST00000392723.5, OTTHUMT00000034916
    Conserved Domains (6) summary
    smart00674
    Location:9681029
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    sd00017
    Location:479500
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:443476
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam09606
    Location:48304
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl21549
    Location:11031227
    rve; Integrase core domain
    cl27427
    Location:218409
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    151402724..151459465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245005.2XP_005245062.1  pogo transposable element with ZNF domain isoform X5

    See identical proteins and their annotated locations for XP_005245062.1

    UniProtKB/Swiss-Prot
    Q7Z3K3
    Related
    ENSP00000418408.1, OTTHUMP00000042874, ENST00000491586.5
    Conserved Domains (6) summary
    smart00674
    Location:9681029
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    sd00017
    Location:479500
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:443476
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam09606
    Location:48304
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl21549
    Location:11031227
    rve; Integrase core domain
    cl27427
    Location:218409
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
  2. XM_017000744.1XP_016856233.1  pogo transposable element with ZNF domain isoform X1

  3. XM_024454305.1XP_024310073.1  pogo transposable element with ZNF domain isoform X4

    Conserved Domains (6) summary
    smart00674
    Location:9791040
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    sd00017
    Location:539560
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:503536
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl21549
    Location:11141238
    rve; Integrase core domain
    cl26464
    Location:275460
    Atrophin-1; Atrophin-1 family
    cl27427
    Location:420469
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
  4. XM_017000748.1XP_016856237.1  pogo transposable element with ZNF domain isoform X5

    UniProtKB/Swiss-Prot
    Q7Z3K3
    Conserved Domains (6) summary
    smart00674
    Location:9681029
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    sd00017
    Location:479500
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:443476
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam09606
    Location:48304
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl21549
    Location:11031227
    rve; Integrase core domain
    cl27427
    Location:218409
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
  5. XM_005245006.5XP_005245063.1  pogo transposable element with ZNF domain isoform X5

    See identical proteins and their annotated locations for XP_005245063.1

    UniProtKB/Swiss-Prot
    Q7Z3K3
    Conserved Domains (6) summary
    smart00674
    Location:9681029
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    sd00017
    Location:479500
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:443476
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam09606
    Location:48304
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl21549
    Location:11031227
    rve; Integrase core domain
    cl27427
    Location:218409
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
  6. XM_017000749.1XP_016856238.1  pogo transposable element with ZNF domain isoform X5

    UniProtKB/Swiss-Prot
    Q7Z3K3
    Conserved Domains (6) summary
    smart00674
    Location:9681029
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    sd00017
    Location:479500
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:443476
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam09606
    Location:48304
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl21549
    Location:11031227
    rve; Integrase core domain
    cl27427
    Location:218409
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
  7. XM_024454306.1XP_024310074.1  pogo transposable element with ZNF domain isoform X6

    Conserved Domains (5) summary
    smart00674
    Location:621682
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    sd00017
    Location:132153
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:96129
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl21549
    Location:756880
    rve; Integrase core domain
    cl27427
    Location:1362
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
  8. XM_005245001.2XP_005245058.1  pogo transposable element with ZNF domain isoform X2

    See identical proteins and their annotated locations for XP_005245058.1

    UniProtKB/Swiss-Prot
    Q7Z3K3
    Conserved Domains (6) summary
    smart00674
    Location:10211082
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    sd00017
    Location:532553
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:496529
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam09606
    Location:101357
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl21549
    Location:11561280
    rve; Integrase core domain
    cl27427
    Location:271462
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
  9. XM_017000746.1XP_016856235.1  pogo transposable element with ZNF domain isoform X3

    UniProtKB/Swiss-Prot
    Q7Z3K3
    Conserved Domains (5) summary
    smart00674
    Location:10121073
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    sd00017
    Location:523544
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:487520
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl21549
    Location:11471271
    rve; Integrase core domain
    cl27427
    Location:404453
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
  10. XM_005245000.4XP_005245057.1  pogo transposable element with ZNF domain isoform X2

    See identical proteins and their annotated locations for XP_005245057.1

    UniProtKB/Swiss-Prot
    Q7Z3K3
    Conserved Domains (6) summary
    smart00674
    Location:10211082
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    sd00017
    Location:532553
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:496529
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam09606
    Location:101357
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl21549
    Location:11561280
    rve; Integrase core domain
    cl27427
    Location:271462
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
  11. XM_005244999.3XP_005245056.1  pogo transposable element with ZNF domain isoform X2

    See identical proteins and their annotated locations for XP_005245056.1

    UniProtKB/Swiss-Prot
    Q7Z3K3
    Conserved Domains (6) summary
    smart00674
    Location:10211082
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    sd00017
    Location:532553
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:496529
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam09606
    Location:101357
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl21549
    Location:11561280
    rve; Integrase core domain
    cl27427
    Location:271462
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
  12. XM_017000745.2XP_016856234.1  pogo transposable element with ZNF domain isoform X3

    UniProtKB/Swiss-Prot
    Q7Z3K3
    Conserved Domains (5) summary
    smart00674
    Location:10121073
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    sd00017
    Location:523544
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:487520
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl21549
    Location:11471271
    rve; Integrase core domain
    cl27427
    Location:404453
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

RNA

  1. XR_002959801.1 RNA Sequence

    Related
    ENST00000358476.7
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