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POGZ pogo transposable element derived with ZNF domain [ Homo sapiens (human) ]

Gene ID: 23126, updated on 3-Dec-2024

Summary

Official Symbol
POGZprovided by HGNC
Official Full Name
pogo transposable element derived with ZNF domainprovided by HGNC
Primary source
HGNC:HGNC:18801
See related
Ensembl:ENSG00000143442 MIM:614787; AllianceGenome:HGNC:18801
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRD37; WHSUS; ZNF635; ZNF280E; ZNF635m
Summary
The protein encoded by this gene appears to be a zinc finger protein containing a transposase domain at the C-terminus. This protein was found to interact with the transcription factor SP1 in a yeast two-hybrid system. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Aug 2010]
Expression
Ubiquitous expression in ovary (RPKM 11.8), testis (RPKM 9.5) and 25 other tissues See more
Orthologs
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Genomic context

See POGZ in Genome Data Viewer
Location:
1q21.3
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (151402724..151459494, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (150526433..150583190, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151375200..151431970, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:151342446-151343117 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:151343118-151343788 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:151344535-151345118 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:151345119-151345702 Neighboring gene selenium binding protein 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:151371406-151372128 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:151372129-151372850 Neighboring gene proteasome 20S subunit beta 4 Neighboring gene Sharpr-MPRA regulatory region 7521 Neighboring gene RNY4 pseudogene 25 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1321 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1322 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1721 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:151476367-151476867 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:151482940-151483516 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:151483517-151484092 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1722 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:151485246-151485822 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:151485823-151486398 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:151495500-151496035 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:151495990-151497189 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene cingulin Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:151511530-151512046 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:151512562-151513077 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:151513078-151513592 Neighboring gene tuftelin 1 Neighboring gene microRNA 554

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2017-12-27)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2017-12-27)

ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol The IN catalytic core domain has a higher binding affinity (Kd) for PSIP1 (LEDGF/p75) than the physiological binding partner, POGZ PubMed
gag-pol The HIV-1 IN interaction site on the PSIP1 (LEDGF/p75) integrase binding domain (IBD) overlaps with that of POGZ PubMed
gag-pol HIV-1 IN efficiently displaces POGZ from LEDGF/p75 PubMed
gag-pol A domesticated transposase, POGZ, carries a DDE domain (amino acids 1117-1323) and interacts with LEDGF/p75. PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0461, MGC71543

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
pogo transposable element with ZNF domain
Names
putative protein product of Nbla00003
zinc finger protein 280E
zinc finger protein 635

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046601.1 RefSeqGene

    Range
    4972..61742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001194937.2NP_001181866.1  pogo transposable element with ZNF domain isoform 4

    See identical proteins and their annotated locations for NP_001181866.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
    Source sequence(s)
    AB007930, AJ242979, AK300307, AL589764, BX537838, BX649163
    Consensus CDS
    CCDS53366.1
    UniProtKB/TrEMBL
    A0AA34QVU4
    Related
    ENSP00000386836.1, ENST00000409503.5
    Conserved Domains (5) summary
    smart00674
    Location:10121073
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    sd00017
    Location:523544
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:487520
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl21549
    Location:11471271
    rve; Integrase core domain
    cl27427
    Location:404453
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
  2. NM_001194938.2NP_001181867.1  pogo transposable element with ZNF domain isoform 5

    See identical proteins and their annotated locations for NP_001181867.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an in-frame exon and uses an alternate in-frame splice site to variant 1. This results in a shorter protein (isoform 5), compared to isoform 1.
    Source sequence(s)
    AB007930, AJ242979, AK300307, AK302501, AL589764, BX537838, BX649163
    Consensus CDS
    CCDS53365.1
    UniProtKB/TrEMBL
    A0AA34QVU4
    Related
    ENSP00000431259.1, ENST00000531094.5
    Conserved Domains (5) summary
    smart00674
    Location:9591020
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    sd00017
    Location:470491
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:434467
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl21549
    Location:10941218
    rve; Integrase core domain
    cl27427
    Location:351400
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
  3. NM_001410860.1NP_001397789.1  pogo transposable element with ZNF domain isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL589764
    Consensus CDS
    CCDS91052.1
    UniProtKB/TrEMBL
    A0A8V8TQ67, A0AA34QVU4
    Related
    ENSP00000515214.1, ENST00000703168.1
  4. NM_015100.4NP_055915.2  pogo transposable element with ZNF domain isoform 1

    See identical proteins and their annotated locations for NP_055915.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB007930, AJ242979, AL589764, BX537838, BX649163
    Consensus CDS
    CCDS997.1
    UniProtKB/Swiss-Prot
    B4DTP8, B4DYL9, B7ZBY5, E9PM80, O75049, Q3LIC4, Q5SZS1, Q5SZS2, Q5SZS3, Q5SZS4, Q7Z3K3, Q8TDZ7, Q9Y4X7
    UniProtKB/TrEMBL
    A0AA34QVU4
    Related
    ENSP00000271715.2, ENST00000271715.7
    Conserved Domains (6) summary
    smart00674
    Location:10211082
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    sd00017
    Location:532553
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:496529
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam09606
    Location:101357
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl21549
    Location:11561280
    rve; Integrase core domain
    cl27427
    Location:271462
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
  5. NM_145796.4NP_665739.3  pogo transposable element with ZNF domain isoform 3

    See identical proteins and their annotated locations for NP_665739.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two in-frame exons compared to variant 1. The resulting isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AB007930, AJ242979, AK300307, AL589764, BX537561, BX537838, BX649163
    Consensus CDS
    CCDS44222.2
    UniProtKB/TrEMBL
    A0AA34QVU4
    Related
    ENSP00000357856.2, ENST00000368863.6
    Conserved Domains (5) summary
    smart00674
    Location:926987
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    sd00017
    Location:437458
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:401434
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl21549
    Location:10611185
    rve; Integrase core domain
    cl27427
    Location:180367
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
  6. NM_207171.2NP_997054.1  pogo transposable element with ZNF domain isoform 2

    See identical proteins and their annotated locations for NP_997054.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame exon compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB007930, AL589764, BX537561, BX649163
    Consensus CDS
    CCDS998.1
    UniProtKB/TrEMBL
    A0AA34QVU4
    Related
    ENST00000358476.7
    Conserved Domains (6) summary
    smart00674
    Location:9681029
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    sd00017
    Location:479500
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:443476
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam09606
    Location:48304
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl21549
    Location:11031227
    rve; Integrase core domain
    cl27427
    Location:218409
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    151402724..151459494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245005.3XP_005245062.1  pogo transposable element with ZNF domain isoform X5

    See identical proteins and their annotated locations for XP_005245062.1

    UniProtKB/TrEMBL
    A0AA34QVU4
    Related
    ENSP00000376484.1, ENST00000392723.6
    Conserved Domains (6) summary
    smart00674
    Location:9681029
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    sd00017
    Location:479500
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:443476
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam09606
    Location:48304
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl21549
    Location:11031227
    rve; Integrase core domain
    cl27427
    Location:218409
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
  2. XM_047450068.1XP_047306024.1  pogo transposable element with ZNF domain isoform X6

    UniProtKB/TrEMBL
    A0AA34QVU4
  3. XM_017000748.2XP_016856237.2  pogo transposable element with ZNF domain isoform X4

    UniProtKB/TrEMBL
    A0AA34QVU4
  4. XM_047450065.1XP_047306021.1  pogo transposable element with ZNF domain isoform X2

    UniProtKB/TrEMBL
    A0AA34QVU4
  5. XM_047450069.1XP_047306025.1  pogo transposable element with ZNF domain isoform X7

    UniProtKB/TrEMBL
    A0AA34QVU4
  6. XM_017000746.2XP_016856235.1  pogo transposable element with ZNF domain isoform X3

    UniProtKB/TrEMBL
    A0AA34QVU4
    Conserved Domains (5) summary
    smart00674
    Location:10121073
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    sd00017
    Location:523544
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:487520
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl21549
    Location:11471271
    rve; Integrase core domain
    cl27427
    Location:404453
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
  7. XM_005245000.5XP_005245057.1  pogo transposable element with ZNF domain isoform X1

    See identical proteins and their annotated locations for XP_005245057.1

    UniProtKB/Swiss-Prot
    B4DTP8, B4DYL9, B7ZBY5, E9PM80, O75049, Q3LIC4, Q5SZS1, Q5SZS2, Q5SZS3, Q5SZS4, Q7Z3K3, Q8TDZ7, Q9Y4X7
    UniProtKB/TrEMBL
    A0AA34QVU4
    Conserved Domains (6) summary
    smart00674
    Location:10211082
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    sd00017
    Location:532553
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:496529
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam09606
    Location:101357
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl21549
    Location:11561280
    rve; Integrase core domain
    cl27427
    Location:271462
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
  8. XM_047450064.1XP_047306020.1  pogo transposable element with ZNF domain isoform X1

    UniProtKB/Swiss-Prot
    B4DTP8, B4DYL9, B7ZBY5, E9PM80, O75049, Q3LIC4, Q5SZS1, Q5SZS2, Q5SZS3, Q5SZS4, Q7Z3K3, Q8TDZ7, Q9Y4X7
    UniProtKB/TrEMBL
    A0AA34QVU4
    Related
    ENSP00000390156.2, ENST00000439756.2
  9. XM_047450070.1XP_047306026.1  pogo transposable element with ZNF domain isoform X8

  10. XM_047450074.1XP_047306030.1  pogo transposable element with ZNF domain isoform X9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    150526433..150583190 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054335324.1XP_054191299.1  pogo transposable element with ZNF domain isoform X5

    UniProtKB/TrEMBL
    A0AA34QVU4
  2. XM_054335323.1XP_054191298.1  pogo transposable element with ZNF domain isoform X4

    UniProtKB/TrEMBL
    A0AA34QVU4
  3. XM_054335321.1XP_054191296.1  pogo transposable element with ZNF domain isoform X2

    UniProtKB/TrEMBL
    A0AA34QVU4
  4. XM_054335325.1XP_054191300.1  pogo transposable element with ZNF domain isoform X6

    UniProtKB/TrEMBL
    A0AA34QVU4
  5. XM_054335326.1XP_054191301.1  pogo transposable element with ZNF domain isoform X7

    UniProtKB/TrEMBL
    A0AA34QVU4
  6. XM_054335322.1XP_054191297.1  pogo transposable element with ZNF domain isoform X3

    UniProtKB/TrEMBL
    A0AA34QVU4
  7. XM_054335319.1XP_054191294.1  pogo transposable element with ZNF domain isoform X1

    UniProtKB/Swiss-Prot
    B4DTP8, B4DYL9, B7ZBY5, E9PM80, O75049, Q3LIC4, Q5SZS1, Q5SZS2, Q5SZS3, Q5SZS4, Q7Z3K3, Q8TDZ7, Q9Y4X7
    UniProtKB/TrEMBL
    A0AA34QVU4
  8. XM_054335320.1XP_054191295.1  pogo transposable element with ZNF domain isoform X1

    UniProtKB/Swiss-Prot
    B4DTP8, B4DYL9, B7ZBY5, E9PM80, O75049, Q3LIC4, Q5SZS1, Q5SZS2, Q5SZS3, Q5SZS4, Q7Z3K3, Q8TDZ7, Q9Y4X7
    UniProtKB/TrEMBL
    A0AA34QVU4
  9. XM_054335327.1XP_054191302.1  pogo transposable element with ZNF domain isoform X10

    UniProtKB/TrEMBL
    A0AA34QVU4
  10. XM_054335328.1XP_054191303.1  pogo transposable element with ZNF domain isoform X8

  11. XM_054335329.1XP_054191304.1  pogo transposable element with ZNF domain isoform X9