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Chrna9 cholinergic receptor, nicotinic, alpha polypeptide 9 [ Mus musculus (house mouse) ]

Gene ID: 231252, updated on 21-Apr-2024

Summary

Official Symbol
Chrna9provided by MGI
Official Full Name
cholinergic receptor, nicotinic, alpha polypeptide 9provided by MGI
Primary source
MGI:MGI:1202403
See related
Ensembl:ENSMUSG00000029205 AllianceGenome:MGI:1202403
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acra9; Gm8311; EG666827; 2410015I05Rik
Summary
Enables acetylcholine-gated cation-selective channel activity. Acts upstream of or within cation transport; detection of mechanical stimulus involved in sensory perception of sound; and inner ear morphogenesis. Predicted to be part of acetylcholine-gated channel complex. Predicted to be active in neuron projection and synapse. Predicted to be integral component of plasma membrane. Is expressed in brain. Orthologous to human CHRNA9 (cholinergic receptor nicotinic alpha 9 subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward thymus adult (RPKM 11.4) See more
Orthologs
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Genomic context

Location:
5 C3.1; 5 33.84 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (66092317..66134823)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (65934854..65977486)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32474 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:66301684-66301897 Neighboring gene STARR-seq mESC enhancer starr_13274 Neighboring gene predicted gene, 32556 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:66320476-66320836 Neighboring gene STARR-positive B cell enhancer ABC_E1301 Neighboring gene STARR-positive B cell enhancer ABC_E9642 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:66347227-66347446 Neighboring gene STARR-positive B cell enhancer ABC_E6335 Neighboring gene STARR-seq mESC enhancer starr_13277 Neighboring gene RIKEN cDNA 9130230L23 gene Neighboring gene STARR-seq mESC enhancer starr_13278 Neighboring gene predicted gene, 40310

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chemical synaptic transmission, postsynaptic IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inner ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within monoatomic cation transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within monoatomic cation transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to auditory stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of acetylcholine-gated channel complex ISO
Inferred from Sequence Orthology
more info
 
part_of acetylcholine-gated channel complex NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in cholinergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transmembrane transporter complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
neuronal acetylcholine receptor subunit alpha-9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081104.2NP_001074573.1  neuronal acetylcholine receptor subunit alpha-9 isoform a

    See identical proteins and their annotated locations for NP_001074573.1

    Status: VALIDATED

    Source sequence(s)
    AC115293
    Consensus CDS
    CCDS39101.1
    UniProtKB/TrEMBL
    G3X8Z7
    Related
    ENSMUSP00000031108.7, ENSMUST00000031108.9
    Conserved Domains (3) summary
    TIGR00860
    Location:10474
    LIC; Cation transporter family protein
    pfam02931
    Location:31236
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:244474
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
  2. NM_001403681.1NP_001390610.1  neuronal acetylcholine receptor subunit alpha-9 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC115293
  3. NM_001403682.1NP_001390611.1  neuronal acetylcholine receptor subunit alpha-9 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC115293
  4. NM_001403683.1NP_001390612.1  neuronal acetylcholine receptor subunit alpha-9 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC115293
  5. NM_001403684.1NP_001390613.1  neuronal acetylcholine receptor subunit alpha-9 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC115293

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    66092317..66134823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254389.1XP_030110249.1  neuronal acetylcholine receptor subunit alpha-9 isoform X3

    Conserved Domains (3) summary
    TIGR00860
    Location:2405
    LIC; Cation transporter family protein
    cd03558
    Location:86100
    LGIC_ECD; Cys-loop [structural motif]
    cl28912
    Location:1168
    LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))