Chrna9 cholinergic receptor, nicotinic, alpha polypeptide 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Chrna9provided by MGI
Official Full Name: cholinergic receptor, nicotinic, alpha polypeptide 9provided by MGI
Primary source: MGI:MGI:1202403
See related: Ensembl:ENSMUSG00000029205 AllianceGenome:MGI:1202403
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Acra9; Gm8311; EG666827; 2410015I05Rik
Summary: Enables acetylcholine-gated cation-selective channel activity. Acts upstream of or within cation transport; detection of mechanical stimulus involved in sensory perception of sound; and inner ear morphogenesis. Predicted to be part of acetylcholine-gated channel complex. Predicted to be active in neuron projection and synapse. Predicted to be integral component of plasma membrane. Is expressed in brain. Orthologous to human CHRNA9 (cholinergic receptor nicotinic alpha 9 subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward thymus adult (RPKM 11.4) See more
Orthologs: human all
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Genomic context

Location:: 5 C3.1; 5 33.84 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (66092197..66134829)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (65934854..65977486)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of Chrna9 is regulated by Tbx3 in undifferentiated pluripotent stem cells.
Title: Expression of Chrna9 is regulated by Tbx3 in undifferentiated pluripotent stem cells.
Efferent feedback controls bilateral auditory spontaneous activity.
Title: Efferent feedback controls bilateral auditory spontaneous activity.
Characterization of HA-tagged alpha9 and alpha10 nAChRs in the mouse cochlea.
Title: Characterization of HA-tagged α9 and α10 nAChRs in the mouse cochlea.
Attenuation in Nicotinic Acetylcholine Receptor alpha9 and alpha10 Subunit Double Knock-Out Mice of Experimental Autoimmune Encephalomyelitis.
Title: Attenuation in Nicotinic Acetylcholine Receptor α9 and α10 Subunit Double Knock-Out Mice of Experimental Autoimmune Encephalomyelitis.
nAChR containing the alpha9 subunit might be involved in the homeostasis of osteocytes and therefore in bone mass regulation.
Title: Deletion of nicotinic acetylcholine receptor alpha9 in mice resulted in altered bone structure.
A point mutation in the hair cell's Chrna9 leads to increased gating of the receptor and greatly elongates IPSCs.
Title: A Gain-of-Function Mutation in the α9 Nicotinic Acetylcholine Receptor Alters Medial Olivocochlear Efferent Short-Term Synaptic Plasticity.
Chrna9 is critical for efferent modulation of mammalian type II vestibular hair cells. Type II hair cells from alpha9-/- mice, fail to respond to ACh at all.
Title: ACh-induced hyperpolarization and decreased resistance in mammalian type II vestibular hair cells.
we developed RgIA4, a peptide that exhibits high potency for both human and rodent a9a10 nAChRs, and was at least 1,000-fold more selective for a9a10 nAChRs vs. all other molecular targets tested, including opioid and GABAB receptors
Title: Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain.
This study demonstrated that Alpha-9 nicotinic acetylcholine receptors mediate hypothermic responses elicited by provocative motion in mice.
Title: Alpha-9 nicotinic acetylcholine receptors mediate hypothermic responses elicited by provocative motion in mice.
In this study present study have shown that loss of alpha9-nAChRs also affects vestibulo-ocular reflex compensation, suggesting that the mice efferent vestibular system plays an important role in vestibular plasticity.
Title: The mammalian efferent vestibular system plays a crucial role in vestibulo-ocular reflex compensation after unilateral labyrinthectomy.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (1)

General gene information

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Homology

Homologs of the Chrna9 gene: The Chrna9 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 485 organisms have orthologs with human gene Chrna9
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acetylcholine-gated monoatomic cation-selective channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables acetylcholine-gated monoatomic cation-selective channel activity	ISO Inferred from Sequence Orthology more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane depolarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane depolarization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic cation transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in nervous system process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of nitric oxide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to auditory stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to auditory stimulus	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
part_of acetylcholine-gated channel complex	ISO Inferred from Sequence Orthology more info
part_of acetylcholine-gated channel complex	NAS Non-traceable Author Statement more info	PubMed
is_active_in cholinergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: neuronal acetylcholine receptor subunit alpha-9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081104.2 → NP_001074573.1 neuronal acetylcholine receptor subunit alpha-9 isoform a

See identical proteins and their annotated locations for NP_001074573.1

Status: VALIDATED

Source sequence(s)

AC115293

Consensus CDS

CCDS39101.1

UniProtKB/TrEMBL

G3X8Z7

Related

ENSMUSP00000031108.7, ENSMUST00000031108.9

Conserved Domains (3) summary

TIGR00860
Location:10 → 474

LIC; Cation transporter family protein

pfam02931
Location:31 → 236

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:244 → 474

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_001403681.1 → NP_001390610.1 neuronal acetylcholine receptor subunit alpha-9 isoform b

Status: VALIDATED

Source sequence(s)

AC115293
NM_001403682.1 → NP_001390611.1 neuronal acetylcholine receptor subunit alpha-9 isoform c

Status: VALIDATED

Source sequence(s)

AC115293
NM_001403683.1 → NP_001390612.1 neuronal acetylcholine receptor subunit alpha-9 isoform d

Status: VALIDATED

Source sequence(s)

AC115293
NM_001403684.1 → NP_001390613.1 neuronal acetylcholine receptor subunit alpha-9 isoform d

Status: VALIDATED

Source sequence(s)

AC115293

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

66092197..66134829

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006503947.3 → XP_006504010.1 neuronal acetylcholine receptor subunit alpha-9 isoform X3

Conserved Domains (3) summary

TIGR00860
Location:2 → 405

LIC; Cation transporter family protein

cd03558
Location:86 → 100

LGIC_ECD; Cys-loop [structural motif]

cl28912
Location:1 → 168

LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))
XM_006503945.3 → XP_006504008.1 neuronal acetylcholine receptor subunit alpha-9 isoform X1

Conserved Domains (2) summary

TIGR00860
Location:17 → 470

LIC; Cation transporter family protein

cd19022
Location:27 → 233

LGIC_ECD_nAChR_A9; extracellular domain of neuronal acetylcholine receptor subunit alpha 9 (CHRNA9)
XM_030254389.1 → XP_030110249.1 neuronal acetylcholine receptor subunit alpha-9 isoform X3

Conserved Domains (3) summary

TIGR00860
Location:2 → 405

LIC; Cation transporter family protein

cd03558
Location:86 → 100

LGIC_ECD; Cys-loop [structural motif]

cl28912
Location:1 → 168

LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))
XM_006503946.5 → XP_006504009.1 neuronal acetylcholine receptor subunit alpha-9 isoform X2

Conserved Domains (2) summary

TIGR00860
Location:12 → 466

LIC; Cation transporter family protein

cd19022
Location:23 → 229

LGIC_ECD_nAChR_A9; extracellular domain of neuronal acetylcholine receptor subunit alpha 9 (CHRNA9)