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CAMTA2 calmodulin binding transcription activator 2 [ Homo sapiens (human) ]

Gene ID: 23125, updated on 18-Nov-2018

Summary

Official Symbol
CAMTA2provided by HGNC
Official Full Name
calmodulin binding transcription activator 2provided by HGNC
Primary source
HGNC:HGNC:18807
See related
Ensembl:ENSG00000108509 MIM:611508; Vega:OTTHUMG00000099417
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the calmodulin-binding transcription activator protein family. Members of this family share a common domain structure that consists of a transcription activation domain, a DNA-binding domain, and a calmodulin-binding domain. The encoded protein may be a transcriptional coactivator of genes involved in cardiac growth. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2010]
Expression
Ubiquitous expression in brain (RPKM 16.2), testis (RPKM 10.6) and 25 other tissues See more
Orthologs

Genomic context

See CAMTA2 in Genome Data Viewer
Location:
17p13.2
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (4967992..4988281, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4871287..4890960, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene enolase 3 Neighboring gene sperm associated antigen 7 Neighboring gene microRNA 6864 Neighboring gene microRNA 6865 Neighboring gene uncharacterized LOC101927979 Neighboring gene inhibitor of CDK, cyclin A1 interacting protein 1 Neighboring gene kinesin family member 1C Neighboring gene uncharacterized LOC102724009 Neighboring gene uncharacterized LOC105371502 Neighboring gene uncharacterized LOC105371501

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0909

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
histone deacetylase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor binding IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
calmodulin-binding transcription activator 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171166.1NP_001164637.1  calmodulin-binding transcription activator 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, has multiple differences in the coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC004771, AL833974, BC010050, DB275145
    Consensus CDS
    CCDS54073.1
    UniProtKB/Swiss-Prot
    O94983
    Related
    ENSP00000370712.5, OTTHUMP00000257584, ENST00000381311.9, OTTHUMT00000438758
    Conserved Domains (5) summary
    smart01076
    Location:36152
    CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
    cd00204
    Location:713811
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01833
    Location:536616
    TIG; IPT/TIG domain
    pfam13637
    Location:713777
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:712755
    ANK; ANK repeat [structural motif]
  2. NM_001171167.1NP_001164638.1  calmodulin-binding transcription activator 2 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' and 3' UTRs and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 4) has distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC004771, AL831849, BC142606
    Consensus CDS
    CCDS54072.1
    UniProtKB/Swiss-Prot
    O94983
    Related
    ENSP00000412886.3, OTTHUMP00000257581, ENST00000414043.7, OTTHUMT00000438755
    Conserved Domains (5) summary
    smart01076
    Location:57173
    CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
    cd00204
    Location:734832
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01833
    Location:557637
    TIG; IPT/TIG domain
    pfam13637
    Location:734798
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:733776
    ANK; ANK repeat [structural motif]
  3. NM_001171168.1NP_001164639.1  calmodulin-binding transcription activator 2 isoform 3

    See identical proteins and their annotated locations for NP_001164639.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, has multiple differences in the coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC004771, AL831849
    Consensus CDS
    CCDS54071.1
    UniProtKB/Swiss-Prot
    O94983
    Related
    ENSP00000354828.5, OTTHUMP00000257582, ENST00000361571.9, OTTHUMT00000438756
    Conserved Domains (5) summary
    cd00204
    Location:710808
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01833
    Location:533613
    TIG; IPT/TIG domain
    pfam13637
    Location:710774
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:709752
    ANK; ANK repeat [structural motif]
    cl04295
    Location:57149
    CG-1; CG-1 domain
  4. NM_015099.3NP_055914.2  calmodulin-binding transcription activator 2 isoform 1

    See identical proteins and their annotated locations for NP_055914.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AB020716, AC004771, DB275145
    Consensus CDS
    CCDS11063.1
    UniProtKB/Swiss-Prot
    O94983
    Related
    ENSP00000321813.7, OTTHUMP00000125265, ENST00000348066.7, OTTHUMT00000216876
    Conserved Domains (5) summary
    smart01076
    Location:34150
    CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
    cd00204
    Location:711809
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01833
    Location:534614
    TIG; IPT/TIG domain
    pfam13637
    Location:711775
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:710753
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    4967992..4988281 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721481.4XP_006721544.1  calmodulin-binding transcription activator 2 isoform X6

    See identical proteins and their annotated locations for XP_006721544.1

    UniProtKB/TrEMBL
    B7ZM30
    Conserved Domains (5) summary
    cd00204
    Location:687785
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01833
    Location:510590
    TIG; IPT/TIG domain
    pfam13637
    Location:687751
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:686729
    ANK; ANK repeat [structural motif]
    cl04295
    Location:34126
    CG-1; CG-1 domain
  2. XM_006721478.4XP_006721541.1  calmodulin-binding transcription activator 2 isoform X5

    UniProtKB/TrEMBL
    I3L3W6
    Related
    ENSP00000460779.1, OTTHUMP00000257583, ENST00000572543.5
    Conserved Domains (5) summary
    smart01076
    Location:34155
    CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
    cd00204
    Location:716814
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01833
    Location:539619
    TIG; IPT/TIG domain
    pfam13637
    Location:716780
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:715758
    ANK; ANK repeat [structural motif]
  3. XM_011523747.3XP_011522049.1  calmodulin-binding transcription activator 2 isoform X2

    Conserved Domains (5) summary
    smart01076
    Location:57173
    CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
    cd00204
    Location:734832
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01833
    Location:557637
    TIG; IPT/TIG domain
    pfam13637
    Location:734798
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:733776
    ANK; ANK repeat [structural motif]
  4. XM_011523748.3XP_011522050.1  calmodulin-binding transcription activator 2 isoform X3

    Conserved Domains (5) summary
    smart01076
    Location:57178
    CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
    cd00204
    Location:739837
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01833
    Location:562642
    TIG; IPT/TIG domain
    pfam13637
    Location:739803
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:738781
    ANK; ANK repeat [structural motif]
  5. XM_011523746.3XP_011522048.1  calmodulin-binding transcription activator 2 isoform X1

    Conserved Domains (5) summary
    smart01076
    Location:57178
    CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
    cd00204
    Location:739837
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01833
    Location:562642
    TIG; IPT/TIG domain
    pfam13637
    Location:739803
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:738781
    ANK; ANK repeat [structural motif]
  6. XM_006721482.3XP_006721545.1  calmodulin-binding transcription activator 2 isoform X7

    Conserved Domains (4) summary
    cd00204
    Location:524622
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01833
    Location:347427
    TIG; IPT/TIG domain
    pfam13637
    Location:524588
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:523566
    ANK; ANK repeat [structural motif]
  7. XM_011523749.3XP_011522051.1  calmodulin-binding transcription activator 2 isoform X4

    Conserved Domains (5) summary
    smart01076
    Location:57173
    CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
    cd00204
    Location:734832
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01833
    Location:557637
    TIG; IPT/TIG domain
    pfam13637
    Location:734798
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:733776
    ANK; ANK repeat [structural motif]
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