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CLASP2 cytoplasmic linker associated protein 2 [ Homo sapiens (human) ]

Gene ID: 23122, updated on 22-Jan-2020

Summary

Official Symbol
CLASP2provided by HGNC
Official Full Name
cytoplasmic linker associated protein 2provided by HGNC
Primary source
HGNC:HGNC:17078
See related
Ensembl:ENSG00000163539 MIM:605853
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in brain (RPKM 43.5), adrenal (RPKM 10.5) and 22 other tissues See more
Orthologs

Genomic context

See CLASP2 in Genome Data Viewer
Location:
3p22.3
Exon count:
45
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (33496245..33718356, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (33537737..33759705, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene F-box and leucine rich repeat protein 2 Neighboring gene RNA, U7 small nuclear 110 pseudogene Neighboring gene upstream binding protein 1 Neighboring gene RNA, 5S ribosomal pseudogene 128 Neighboring gene cytochrome c oxidase subunit 6C pseudogene 10 Neighboring gene uncharacterized LOC105377023 Neighboring gene SDA1 domain containing 1 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dystroglycan binding IPI
Inferred from Physical Interaction
more info
PubMed 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule plus-end binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Golgi organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell division IEA
Inferred from Electronic Annotation
more info
 
establishment or maintenance of cell polarity TAS
Traceable Author Statement
more info
PubMed 
exit from mitosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule anchoring IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule nucleation IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule organizing center organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of microtubule depolymerization NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of wound healing, spreading of epidermal cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of basement membrane assembly involved in embryonic body morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of extracellular matrix disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gastrulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of microtubule polymerization or depolymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of microtubule-based process IMP
Inferred from Mutant Phenotype
more info
PubMed 
vesicle targeting IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
basal cortex IDA
Inferred from Direct Assay
more info
PubMed 
cell IEA
Inferred from Electronic Annotation
more info
 
cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
condensed chromosome kinetochore IEA
Inferred from Electronic Annotation
more info
 
cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
colocalizes_with focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
kinetochore microtubule TAS
Traceable Author Statement
more info
PubMed 
membrane HDA PubMed 
microtubule IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with microtubule IDA
Inferred from Direct Assay
more info
PubMed 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with mitotic spindle IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
ruffle membrane IDA
Inferred from Direct Assay
more info
PubMed 
trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
CLIP-associating protein 2
Names
CLIP-associating protein CLASP2
multiple asters (Mast)-like homolog 2
protein Orbit homolog 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001207044.3NP_001193973.1  CLIP-associating protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001193973.1

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    UniProtKB/Swiss-Prot
    O75122
    Related
    ENSP00000417518.2, ENST00000480013.6
    Conserved Domains (2) summary
    sd00044
    Location:655682
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:94305
    CLASP_N; CLASP N terminal
  2. NM_001365627.1NP_001352556.1  CLIP-associating protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    Conserved Domains (3) summary
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:327538
    CLASP_N; CLASP N terminal
  3. NM_001365628.1NP_001352557.1  CLIP-associating protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    Conserved Domains (3) summary
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:328539
    CLASP_N; CLASP N terminal
  4. NM_001365629.1NP_001352558.1  CLIP-associating protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    Conserved Domains (3) summary
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:327538
    CLASP_N; CLASP N terminal
  5. NM_001365630.1NP_001352559.1  CLIP-associating protein 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    Conserved Domains (3) summary
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:327538
    CLASP_N; CLASP N terminal
  6. NM_001365631.1NP_001352560.1  CLIP-associating protein 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    Conserved Domains (3) summary
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:327538
    CLASP_N; CLASP N terminal
  7. NM_001365632.1NP_001352561.1  CLIP-associating protein 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    Conserved Domains (3) summary
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:327538
    CLASP_N; CLASP N terminal
  8. NM_001365633.1NP_001352562.1  CLIP-associating protein 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    Conserved Domains (3) summary
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:328539
    CLASP_N; CLASP N terminal
  9. NM_001365634.1NP_001352563.1  CLIP-associating protein 2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    Conserved Domains (3) summary
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:327538
    CLASP_N; CLASP N terminal
  10. NM_001375694.1NP_001362623.1  CLIP-associating protein 2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
  11. NM_001375697.1NP_001362626.1  CLIP-associating protein 2 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
  12. NM_001375700.1NP_001362629.1  CLIP-associating protein 2 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
  13. NM_001375701.1NP_001362630.1  CLIP-associating protein 2 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    Related
    ENSP00000419974.2, ENST00000468888.6
  14. NM_001375703.1NP_001362632.1  CLIP-associating protein 2 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
  15. NM_001375705.1NP_001362634.1  CLIP-associating protein 2 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
  16. NM_001375713.1NP_001362642.1  CLIP-associating protein 2 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
  17. NM_001375715.1NP_001362644.1  CLIP-associating protein 2 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
  18. NM_001375716.1NP_001362645.1  CLIP-associating protein 2 isoform 19

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
  19. NM_001375718.1NP_001362647.1  CLIP-associating protein 2 isoform 20

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    Related
    ENSP00000489023.1, ENST00000635664.1
  20. NM_001375720.1NP_001362649.1  CLIP-associating protein 2 isoform 21

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
  21. NM_015097.3NP_055912.2  CLIP-associating protein 2 isoform 1

    See identical proteins and their annotated locations for NP_055912.2

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    UniProtKB/Swiss-Prot
    O75122
    Conserved Domains (3) summary
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:328539
    CLASP_N; CLASP N terminal
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    33496245..33718356 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005959.1XP_016861448.1  CLIP-associating protein 2 isoform X21

    UniProtKB/TrEMBL
    E7ERI8
    Related
    ENSP00000382297.4, ENST00000399362.8
  2. XM_006713052.1XP_006713115.1  CLIP-associating protein 2 isoform X19

    Conserved Domains (3) summary
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:327538
    CLASP_N; CLASP N terminal
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]
  3. XM_017005954.1XP_016861443.1  CLIP-associating protein 2 isoform X13

  4. XM_017005948.1XP_016861437.1  CLIP-associating protein 2 isoform X5

  5. XM_017005947.1XP_016861436.1  CLIP-associating protein 2 isoform X4

  6. XM_017005951.1XP_016861440.1  CLIP-associating protein 2 isoform X9

  7. XM_006713041.1XP_006713104.1  CLIP-associating protein 2 isoform X2

    Conserved Domains (4) summary
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam10265
    Location:686790
    DUF2217; Uncharacterized conserved protein (DUF2217)
    pfam12348
    Location:327538
    CLASP_N; CLASP N terminal
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]
  8. XM_017005960.1XP_016861449.1  CLIP-associating protein 2 isoform X22

  9. XM_017005965.1XP_016861454.1  CLIP-associating protein 2 isoform X28

  10. XM_011533515.1XP_011531817.1  CLIP-associating protein 2 isoform X6

    Conserved Domains (4) summary
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam10265
    Location:673777
    DUF2217; Uncharacterized conserved protein (DUF2217)
    pfam12348
    Location:328539
    CLASP_N; CLASP N terminal
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]
  11. XM_017005963.1XP_016861452.1  CLIP-associating protein 2 isoform X26

  12. XM_017005957.1XP_016861446.1  CLIP-associating protein 2 isoform X18

  13. XM_006713053.1XP_006713116.1  CLIP-associating protein 2 isoform X24

    Conserved Domains (3) summary
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:328539
    CLASP_N; CLASP N terminal
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]
  14. XM_006713050.1XP_006713113.1  CLIP-associating protein 2 isoform X17

    Conserved Domains (3) summary
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:328539
    CLASP_N; CLASP N terminal
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]
  15. XM_006713048.1XP_006713111.1  CLIP-associating protein 2 isoform X12

    Conserved Domains (3) summary
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:328539
    CLASP_N; CLASP N terminal
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]
  16. XM_017005956.1XP_016861445.1  CLIP-associating protein 2 isoform X16

  17. XM_017005955.1XP_016861444.1  CLIP-associating protein 2 isoform X14

  18. XM_006713042.1XP_006713105.1  CLIP-associating protein 2 isoform X3

    Conserved Domains (4) summary
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam10265
    Location:687791
    DUF2217; Uncharacterized conserved protein (DUF2217)
    pfam12348
    Location:328539
    CLASP_N; CLASP N terminal
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]
  19. XM_017005950.1XP_016861439.1  CLIP-associating protein 2 isoform X8

  20. XM_006713040.1XP_006713103.1  CLIP-associating protein 2 isoform X1

    Conserved Domains (4) summary
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam10265
    Location:687791
    DUF2217; Uncharacterized conserved protein (DUF2217)
    pfam12348
    Location:328539
    CLASP_N; CLASP N terminal
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]
  21. XM_017005949.1XP_016861438.1  CLIP-associating protein 2 isoform X7

  22. XM_017005986.2XP_016861475.1  CLIP-associating protein 2 isoform X48

  23. XM_017005983.2XP_016861472.1  CLIP-associating protein 2 isoform X44

  24. XM_017005970.2XP_016861459.1  CLIP-associating protein 2 isoform X33

  25. XM_017005984.2XP_016861473.1  CLIP-associating protein 2 isoform X45

    UniProtKB/TrEMBL
    E3W994
    Related
    ENSP00000419305.3, ENST00000461133.8
  26. XM_017005973.2XP_016861462.1  CLIP-associating protein 2 isoform X37

  27. XM_024453408.1XP_024309176.1  CLIP-associating protein 2 isoform X35

    Conserved Domains (2) summary
    sd00044
    Location:10671089
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:94305
    CLASP_N; CLASP N terminal
  28. XM_017005972.2XP_016861461.1  CLIP-associating protein 2 isoform X34

  29. XM_024453410.1XP_024309178.1  CLIP-associating protein 2 isoform X49

    Conserved Domains (2) summary
    sd00044
    Location:620647
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:94305
    CLASP_N; CLASP N terminal
  30. XM_024453409.1XP_024309177.1  CLIP-associating protein 2 isoform X47

    Conserved Domains (2) summary
    sd00044
    Location:626653
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:100311
    CLASP_N; CLASP N terminal
  31. XM_017005976.2XP_016861465.1  CLIP-associating protein 2 isoform X39

  32. XM_017005979.2XP_016861468.1  CLIP-associating protein 2 isoform X41

  33. XM_017005971.2XP_016861460.1  CLIP-associating protein 2 isoform X36

  34. XM_017005969.2XP_016861458.1  CLIP-associating protein 2 isoform X32

  35. XM_017005978.2XP_016861467.1  CLIP-associating protein 2 isoform X40

  36. XM_017005968.2XP_016861457.1  CLIP-associating protein 2 isoform X31

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