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CLASP2 cytoplasmic linker associated protein 2 [ Homo sapiens (human) ]

Gene ID: 23122, updated on 17-Jun-2019

Summary

Official Symbol
CLASP2provided by HGNC
Official Full Name
cytoplasmic linker associated protein 2provided by HGNC
Primary source
HGNC:HGNC:17078
See related
Ensembl:ENSG00000163539 MIM:605853
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in brain (RPKM 43.5), adrenal (RPKM 10.5) and 22 other tissues See more
Orthologs

Genomic context

See CLASP2 in Genome Data Viewer
Location:
3p22.3
Exon count:
44
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (33496245..33718356, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (33537737..33759705, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene F-box and leucine rich repeat protein 2 Neighboring gene RNA, U7 small nuclear 110 pseudogene Neighboring gene upstream binding protein 1 Neighboring gene RNA, 5S ribosomal pseudogene 128 Neighboring gene cytochrome c oxidase subunit 6C pseudogene 10 Neighboring gene uncharacterized LOC105377023 Neighboring gene SDA1 domain containing 1 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • M Phase, organism-specific biosystem (from REACTOME)
    M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
  • Mitotic Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Anaphase, organism-specific biosystemIn anaphase, the paired chromosomes separate at the centromeres, and move to the opposite sides of the cell. The movement of the chromosomes is facilitated by a combination of kinetochore movement al...
  • Mitotic Metaphase and Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Metaphase and Anaphase, organism-specific biosystemMetaphase is marked by the formation of the metaphase plate. The metaphase plate is formed when the spindle fibers align the chromosomes along the middle of the cell. Such an organization helps to ...
  • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
    Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and th...
  • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
    RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
  • RHO GTPases Activate Formins, organism-specific biosystem (from REACTOME)
    RHO GTPases Activate Formins, organism-specific biosystemFormins are a family of proteins with 15 members in mammals, organized into 8 subfamilies. Formins are involved in the regulation of actin cytoskeleton. Many but not all formin family members are act...
  • Resolution of Sister Chromatid Cohesion, organism-specific biosystem (from REACTOME)
    Resolution of Sister Chromatid Cohesion, organism-specific biosystemThe resolution of sister chromatids in mitotic prometaphase involves removal of cohesin complexes from chromosomal arms, with preservation of cohesion at centromeres (Losada et al. 1998, Hauf et al. ...
  • Role of Abl in Robo-Slit signaling, organism-specific biosystem (from REACTOME)
    Role of Abl in Robo-Slit signaling, organism-specific biosystemAbl plays a dual role in the Robo pathway. As a key enzymatic component in the signaling pathway, Abl support repellent signaling (by recruiting the necessary actin binding proteins) and also feed ba...
  • Separation of Sister Chromatids, organism-specific biosystem (from REACTOME)
    Separation of Sister Chromatids, organism-specific biosystemWhile sister chromatids resolve in prometaphase, separating along chromosomal arms, the cohesion of sister centromeres persists until anaphase. At the anaphase onset, the anaphase promoting complex/c...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
  • Signaling by Robo receptor, organism-specific biosystem (from REACTOME)
    Signaling by Robo receptor, organism-specific biosystemThe Roundabout (Robo) family encodes transmembrane receptors that regulate axonal guidance and cell migration. The major function of the Robo receptors is to mediate repulsion of the navigating growt...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dystroglycan binding IPI
Inferred from Physical Interaction
more info
PubMed 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule plus-end binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Golgi organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell division IEA
Inferred from Electronic Annotation
more info
 
establishment or maintenance of cell polarity TAS
Traceable Author Statement
more info
PubMed 
exit from mitosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule anchoring IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule nucleation IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule organizing center organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of microtubule depolymerization NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of wound healing, spreading of epidermal cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of basement membrane assembly involved in embryonic body morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of extracellular matrix disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gastrulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of microtubule polymerization or depolymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of microtubule-based process IMP
Inferred from Mutant Phenotype
more info
PubMed 
vesicle targeting IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
basal cortex IDA
Inferred from Direct Assay
more info
PubMed 
cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
condensed chromosome kinetochore IEA
Inferred from Electronic Annotation
more info
 
cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
colocalizes_with focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
kinetochore microtubule TAS
Traceable Author Statement
more info
PubMed 
membrane HDA PubMed 
microtubule IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with microtubule IDA
Inferred from Direct Assay
more info
PubMed 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with mitotic spindle IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
ruffle membrane IDA
Inferred from Direct Assay
more info
PubMed 
trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
CLIP-associating protein 2
Names
CLIP-associating protein CLASP2
multiple asters (Mast)-like homolog 2
protein Orbit homolog 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001207044.2NP_001193973.1  CLIP-associating protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001193973.1

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    UniProtKB/Swiss-Prot
    O75122
    Related
    ENSP00000417518.2, ENST00000480013.6
    Conserved Domains (2) summary
    sd00044
    Location:655682
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:94305
    CLASP_N; CLASP N terminal
  2. NM_001365627.1NP_001352556.1  CLIP-associating protein 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    AC093114, AC113170, AC132515
    Conserved Domains (3) summary
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:327538
    CLASP_N; CLASP N terminal
  3. NM_001365628.1NP_001352557.1  CLIP-associating protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    Conserved Domains (3) summary
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:328539
    CLASP_N; CLASP N terminal
  4. NM_001365629.1NP_001352558.1  CLIP-associating protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    Conserved Domains (3) summary
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:327538
    CLASP_N; CLASP N terminal
  5. NM_001365630.1NP_001352559.1  CLIP-associating protein 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    Conserved Domains (3) summary
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:327538
    CLASP_N; CLASP N terminal
  6. NM_001365631.1NP_001352560.1  CLIP-associating protein 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    Conserved Domains (3) summary
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:327538
    CLASP_N; CLASP N terminal
  7. NM_001365632.1NP_001352561.1  CLIP-associating protein 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    Conserved Domains (3) summary
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:327538
    CLASP_N; CLASP N terminal
  8. NM_001365633.1NP_001352562.1  CLIP-associating protein 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    Conserved Domains (3) summary
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:328539
    CLASP_N; CLASP N terminal
  9. NM_001365634.1NP_001352563.1  CLIP-associating protein 2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    Conserved Domains (3) summary
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:327538
    CLASP_N; CLASP N terminal
  10. NM_015097.3NP_055912.2  CLIP-associating protein 2 isoform 1

    See identical proteins and their annotated locations for NP_055912.2

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    UniProtKB/Swiss-Prot
    O75122
    Conserved Domains (3) summary
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:328539
    CLASP_N; CLASP N terminal
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    33496245..33718356 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005959.1XP_016861448.1  CLIP-associating protein 2 isoform X21

    UniProtKB/TrEMBL
    E7ERI8
    Related
    ENSP00000382297.4, ENST00000399362.8
  2. XM_006713052.1XP_006713115.1  CLIP-associating protein 2 isoform X19

    Conserved Domains (3) summary
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:327538
    CLASP_N; CLASP N terminal
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]
  3. XM_017005954.1XP_016861443.1  CLIP-associating protein 2 isoform X13

  4. XM_017005948.1XP_016861437.1  CLIP-associating protein 2 isoform X5

  5. XM_017005947.1XP_016861436.1  CLIP-associating protein 2 isoform X4

  6. XM_017005951.1XP_016861440.1  CLIP-associating protein 2 isoform X9

  7. XM_006713041.1XP_006713104.1  CLIP-associating protein 2 isoform X2

    Conserved Domains (4) summary
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam10265
    Location:686790
    DUF2217; Uncharacterized conserved protein (DUF2217)
    pfam12348
    Location:327538
    CLASP_N; CLASP N terminal
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]
  8. XM_017005960.1XP_016861449.1  CLIP-associating protein 2 isoform X22

  9. XM_017005965.1XP_016861454.1  CLIP-associating protein 2 isoform X28

  10. XM_011533515.1XP_011531817.1  CLIP-associating protein 2 isoform X6

    Conserved Domains (4) summary
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam10265
    Location:673777
    DUF2217; Uncharacterized conserved protein (DUF2217)
    pfam12348
    Location:328539
    CLASP_N; CLASP N terminal
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]
  11. XM_017005963.1XP_016861452.1  CLIP-associating protein 2 isoform X26

  12. XM_017005957.1XP_016861446.1  CLIP-associating protein 2 isoform X18

  13. XM_006713053.1XP_006713116.1  CLIP-associating protein 2 isoform X24

    Conserved Domains (3) summary
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:328539
    CLASP_N; CLASP N terminal
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]
  14. XM_006713050.1XP_006713113.1  CLIP-associating protein 2 isoform X17

    Conserved Domains (3) summary
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:328539
    CLASP_N; CLASP N terminal
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]
  15. XM_017005958.1XP_016861447.1  CLIP-associating protein 2 isoform X20

    UniProtKB/TrEMBL
    E7EW49
    Related
    ENSP00000419974.2, ENST00000468888.6
  16. XM_006713048.1XP_006713111.1  CLIP-associating protein 2 isoform X12

    Conserved Domains (3) summary
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:328539
    CLASP_N; CLASP N terminal
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]
  17. XM_017005956.1XP_016861445.1  CLIP-associating protein 2 isoform X16

  18. XM_017005955.1XP_016861444.1  CLIP-associating protein 2 isoform X14

  19. XM_006713042.1XP_006713105.1  CLIP-associating protein 2 isoform X3

    Conserved Domains (4) summary
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam10265
    Location:687791
    DUF2217; Uncharacterized conserved protein (DUF2217)
    pfam12348
    Location:328539
    CLASP_N; CLASP N terminal
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]
  20. XM_017005950.1XP_016861439.1  CLIP-associating protein 2 isoform X8

  21. XM_006713040.1XP_006713103.1  CLIP-associating protein 2 isoform X1

    Conserved Domains (4) summary
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam10265
    Location:687791
    DUF2217; Uncharacterized conserved protein (DUF2217)
    pfam12348
    Location:328539
    CLASP_N; CLASP N terminal
    sd00044
    Location:131157
    HEAT; HEAT repeat [structural motif]
  22. XM_017005949.1XP_016861438.1  CLIP-associating protein 2 isoform X7

  23. XM_017005986.2XP_016861475.1  CLIP-associating protein 2 isoform X48

  24. XM_017005983.2XP_016861472.1  CLIP-associating protein 2 isoform X44

  25. XM_017005970.2XP_016861459.1  CLIP-associating protein 2 isoform X33

  26. XM_017005985.2XP_016861474.1  CLIP-associating protein 2 isoform X46

  27. XM_017005974.2XP_016861463.1  CLIP-associating protein 2 isoform X38

  28. XM_017005984.2XP_016861473.1  CLIP-associating protein 2 isoform X45

    UniProtKB/TrEMBL
    E3W994
    Related
    ENSP00000419305.3, ENST00000461133.8
  29. XM_017005973.2XP_016861462.1  CLIP-associating protein 2 isoform X37

  30. XM_024453408.1XP_024309176.1  CLIP-associating protein 2 isoform X35

    Conserved Domains (2) summary
    sd00044
    Location:10671089
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:94305
    CLASP_N; CLASP N terminal
  31. XM_017005972.2XP_016861461.1  CLIP-associating protein 2 isoform X34

  32. XM_024453410.1XP_024309178.1  CLIP-associating protein 2 isoform X49

    Conserved Domains (2) summary
    sd00044
    Location:620647
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:94305
    CLASP_N; CLASP N terminal
  33. XM_024453409.1XP_024309177.1  CLIP-associating protein 2 isoform X47

    Conserved Domains (2) summary
    sd00044
    Location:626653
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:100311
    CLASP_N; CLASP N terminal
  34. XM_017005976.2XP_016861465.1  CLIP-associating protein 2 isoform X39

  35. XM_017005982.2XP_016861471.1  CLIP-associating protein 2 isoform X43

    Related
    ENSP00000489023.1, ENST00000635664.1
  36. XM_017005979.2XP_016861468.1  CLIP-associating protein 2 isoform X41

  37. XM_017005971.2XP_016861460.1  CLIP-associating protein 2 isoform X36

  38. XM_017005969.2XP_016861458.1  CLIP-associating protein 2 isoform X32

  39. XM_017005981.2XP_016861470.1  CLIP-associating protein 2 isoform X42

  40. XM_017005978.2XP_016861467.1  CLIP-associating protein 2 isoform X40

  41. XM_017005968.2XP_016861457.1  CLIP-associating protein 2 isoform X31

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