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Cpeb2 cytoplasmic polyadenylation element binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 231207, updated on 5-Jan-2023

Summary

Official Symbol
Cpeb2provided by MGI
Official Full Name
cytoplasmic polyadenylation element binding protein 2provided by MGI
Primary source
MGI:MGI:2442640
See related
Ensembl:ENSMUSG00000039782 AllianceGenome:MGI:2442640
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cpe-bp2; A630055H10Rik
Summary
Enables nucleic acid binding activity and ribosome binding activity. Involved in several processes, including cellular response to arsenic-containing substance; cellular response to hypoxia; and negative regulation of cytoplasmic translation. Acts upstream of or within negative regulation of translational elongation. Located in cytoplasm. Part of messenger ribonucleoprotein complex and polysome. Is expressed in central nervous system. Orthologous to human CPEB2 (cytoplasmic polyadenylation element binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 37.0), CNS E18 (RPKM 7.5) and 21 other tissues See more
Orthologs
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Genomic context

See Cpeb2 in Genome Data Viewer
Location:
5; 5 B3
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (43382692..43447067)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (43225349..43289724)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 43700 Neighboring gene predicted gene 7854 Neighboring gene predicted gene, 46911 Neighboring gene predicted gene 43699 Neighboring gene C1q and tumor necrosis factor related protein 7 Neighboring gene predicted gene 15866

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA 3'-UTR AU-rich region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mRNA regulatory element binding translation repressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mRNA regulatory element binding translation repressor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA regulatory element binding translation repressor activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables poly-pyrimidine tract binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribosomal large subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables ribosomal small subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ribosome binding IDA
Inferred from Direct Assay
more info
PubMed 
enables translation factor activity, RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables translation regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables translation regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to arsenic-containing substance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to arsenic-containing substance ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of cytoplasmic translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cytoplasmic translational elongation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of translational elongation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of translation at synapse, modulating synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of translation at synapse, modulating synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of messenger ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of messenger ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of messenger ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of polysome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cytoplasmic polyadenylation element-binding protein 2
Names
CPE-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177379.2NP_001170850.1  cytoplasmic polyadenylation element-binding protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC105174
    Consensus CDS
    CCDS51487.1
    UniProtKB/TrEMBL
    E9Q5X2
    Related
    ENSMUSP00000125857.2, ENSMUST00000169035.8
    Conserved Domains (4) summary
    COG0724
    Location:722897
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12724
    Location:735826
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:843923
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:918979
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
  2. NM_001368805.1NP_001355734.1  cytoplasmic polyadenylation element-binding protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC105174
    Conserved Domains (3) summary
    cd12724
    Location:768859
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:876956
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:9511012
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
  3. NM_001368806.1NP_001355735.1  cytoplasmic polyadenylation element-binding protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC105174
    Consensus CDS
    CCDS89916.1
    UniProtKB/TrEMBL
    E9Q969
    Related
    ENSMUSP00000130921.3, ENSMUST00000166713.9
    Conserved Domains (3) summary
    cd12724
    Location:765856
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:873953
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:9481009
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
  4. NM_001368807.1NP_001355736.1  cytoplasmic polyadenylation element-binding protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC105174
    Conserved Domains (3) summary
    cd12724
    Location:738829
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:846926
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:921982
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
  5. NM_175937.4NP_787951.2  cytoplasmic polyadenylation element-binding protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC105174
    UniProtKB/TrEMBL
    A0A0H2UH22
    Related
    ENSMUSP00000109699.4, ENSMUST00000114065.9
    Conserved Domains (4) summary
    COG0724
    Location:744919
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12724
    Location:757848
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:865945
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:9401001
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    43382692..43447067
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503929.3XP_006503992.1  cytoplasmic polyadenylation element-binding protein 2 isoform X1

    Conserved Domains (3) summary
    cd12724
    Location:760851
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:868948
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:9431004
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
  2. XM_006503931.3XP_006503994.1  cytoplasmic polyadenylation element-binding protein 2 isoform X2

    Conserved Domains (3) summary
    cd12724
    Location:730821
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:838918
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:913974
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
  3. XM_006503932.4XP_006503995.1  cytoplasmic polyadenylation element-binding protein 2 isoform X3

    Conserved Domains (3) summary
    cd12724
    Location:727818
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:835915
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:910971
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain