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NPIPB3 nuclear pore complex interacting protein family member B3 [ Homo sapiens (human) ]

Gene ID: 23117, updated on 1-Jun-2020

Summary

Official Symbol
NPIPB3provided by HGNC
Official Full Name
nuclear pore complex interacting protein family member B3provided by HGNC
Primary source
HGNC:HGNC:28989
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NPIP; NPIPB; NPIPB5; NPIPL3; KIAA0220L
Expression
Ubiquitous expression in skin (RPKM 36.9), bone marrow (RPKM 26.9) and 24 other tissues See more
Orthologs

Genomic context

See NPIPB3 in Genome Data Viewer
Location:
16p12.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (21402129..21425378, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (21413455..21436658, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene crystallin mu Neighboring gene CRYM antisense RNA 1 Neighboring gene sorting nexin 29 pseudogene 1 Neighboring gene uncharacterized LOC100190986 Neighboring gene SMG1 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of nuclear pore complex interacting protein-like 3 (NPIPL3; KIAA0220L) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ17456, FLJ45371, FLJ54505, FLJ58661, FLJ79358, FLJ98670, KIAA0220, MGC70907, MGC105000

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
nuclear pore complex-interacting protein family member B3
Names
KIAA0220-like protein
PI-3-kinase-related kinase SMG-1 isoform 1 homolog
nuclear pore complex-interacting protein B type
nuclear pore complex-interacting protein-like 3
protein pps22-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130464.3NP_569731.2  nuclear pore complex-interacting protein family member B3

    Status: VALIDATED

    Source sequence(s)
    AK294452, BC036263, BQ950195, DC309942
    Conserved Domains (3) summary
    pfam06409
    Location:41302
    NPIP; Nuclear pore complex interacting protein (NPIP)
    pfam16496
    Location:10321123
    SWIRM-assoc_2; SWIRM-associated domain at the N-terminal
    cl17068
    Location:141
    AFD_class_I; Adenylate forming domain, Class I superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    21402129..21425378 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_017852933.1 Reference GRCh38.p13 PATCHES

    Range
    1679394..1702762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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