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TOGARAM1 TOG array regulator of axonemal microtubules 1 [ Homo sapiens (human) ]

Gene ID: 23116, updated on 4-Jun-2020

Summary

Official Symbol
TOGARAM1provided by HGNC
Official Full Name
TOG array regulator of axonemal microtubules 1provided by HGNC
Primary source
HGNC:HGNC:19959
See related
Ensembl:ENSG00000198718 MIM:617618
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM179B; KIAA0423
Expression
Ubiquitous expression in thyroid (RPKM 6.9), brain (RPKM 6.9) and 25 other tissues See more
Orthologs

Genomic context

See TOGARAM1 in Genome Data Viewer
Location:
14q21.2
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (44962190..45074431)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (45431416..45543634)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927418 Neighboring gene chromosome 14 open reading frame 28 Neighboring gene kelch like family member 28 Neighboring gene uncharacterized LOC105370474 Neighboring gene pre-mRNA processing factor 39 Neighboring gene small nucleolar RNA, C/D box 127

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0423, DKFZp686D12126

Gene Ontology Provided by GOA

Function Evidence Code Pubs
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
axoneme assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
non-motile cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of microtubule polymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of microtubule polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
ciliary basal body ISS
Inferred from Sequence or Structural Similarity
more info
 
cilium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cilium ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
TOG array regulator of axonemal microtubules protein 1
Names
crescerin
crescerin-1
family with sequence similarity 179 member B
protein FAM179B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308120.2NP_001295049.1  TOG array regulator of axonemal microtubules protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001295049.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA911186, AK295185, BC065234, BX648723
    Consensus CDS
    CCDS76676.1
    UniProtKB/TrEMBL
    B4DHM7, G3XAE9, Q6P183
    Related
    ENSP00000354917.2, ENST00000361462.7
    Conserved Domains (2) summary
    pfam15741
    Location:8111152
    LRIF1; Ligand-dependent nuclear receptor-interacting factor 1
    sd00044
    Location:395423
    HEAT; HEAT repeat [structural motif]
  2. NM_015091.4NP_055906.2  TOG array regulator of axonemal microtubules protein 1 isoform 2

    See identical proteins and their annotated locations for NP_055906.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AB007883, AK295185, AL049870, BC065234
    Consensus CDS
    CCDS9681.1
    UniProtKB/Swiss-Prot
    Q9Y4F4
    UniProtKB/TrEMBL
    B4DHM7, Q6P183
    Related
    ENSP00000355045.3, ENST00000361577.7
    Conserved Domains (2) summary
    pfam15741
    Location:8111152
    LRIF1; Ligand-dependent nuclear receptor-interacting factor 1
    sd00044
    Location:395423
    HEAT; HEAT repeat [structural motif]

RNA

  1. NR_131765.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate internal exon and contains an additional alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK295185, AL049870, BC057255, BC065234, CR749557

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    44962190..45074431
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536571.1XP_011534873.1  TOG array regulator of axonemal microtubules protein 1 isoform X3

    Conserved Domains (2) summary
    pfam15741
    Location:8111152
    LRIF1; Ligand-dependent nuclear receptor-interacting factor 1
    sd00044
    Location:395423
    HEAT; HEAT repeat [structural motif]
  2. XM_017021099.1XP_016876588.1  TOG array regulator of axonemal microtubules protein 1 isoform X2

  3. XM_017021098.1XP_016876587.1  TOG array regulator of axonemal microtubules protein 1 isoform X1

  4. XM_017021100.1XP_016876589.1  TOG array regulator of axonemal microtubules protein 1 isoform X4

    UniProtKB/Swiss-Prot
    Q9Y4F4
    Related
    ENSP00000451829.1, ENST00000557423.5

RNA

  1. XR_001750194.1 RNA Sequence

  2. XR_001750195.1 RNA Sequence

  3. XR_943403.2 RNA Sequence

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