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Tada2b transcriptional adaptor 2B [ Mus musculus (house mouse) ]

Gene ID: 231151, updated on 5-Mar-2024

Summary

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Official Symbol
Tada2bprovided by MGI
Official Full Name
transcriptional adaptor 2Bprovided by MGI
Primary source
MGI:MGI:3035274
See related
Ensembl:ENSMUSG00000029196 AllianceGenome:MGI:3035274
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm145
Summary
Predicted to enable chromatin binding activity and transcription coactivator activity. Predicted to be involved in chromatin remodeling; positive regulation of histone acetylation; and regulation of transcription by RNA polymerase II. Part of SAGA complex. Orthologous to human TADA2B (transcriptional adaptor 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 15.9), adrenal adult (RPKM 14.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 B3; 5 19.14 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (36631014..36641629, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (36473670..36484285, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene sortilin-related VPS10 domain containing receptor 2 Neighboring gene microRNA 7689 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:36701008-36701161 Neighboring gene STARR-positive B cell enhancer mm9_chr5:36715900-36716201 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:36720744-36720945 Neighboring gene RIKEN cDNA 2210406O10 gene Neighboring gene STARR-positive B cell enhancer ABC_E65 Neighboring gene STARR-positive B cell enhancer ABC_E3572 Neighboring gene GrpE-like 1, mitochondrial Neighboring gene TBC1 domain family, member 14 Neighboring gene coiled-coil domain containing 96 Neighboring gene predicted gene, 32528

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The double-histone-acetyltransferase complex ATAC is essential for mammalian development. Guelman S, et al. Mol Cell Biol, 2009 Mar. PMID 19103755, Free PMC Article
  2. The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes. Nagy Z, et al. Mol Cell Biol, 2009 Mar. PMID 19114550, Free PMC Article
  3. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. Martinez E, et al. Mol Cell Biol, 2001 Oct. PMID 11564863, Free PMC Article
  4. A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. Zhao Y, et al. Mol Cell, 2008 Jan 18. PMID 18206972
  5. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of RNA splicing NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SAGA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SAGA complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of SAGA-type complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SAGA-type complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transcriptional adapter 2-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170454.1 → NP_001163925.1  transcriptional adapter 2-beta

    See identical proteins and their annotated locations for NP_001163925.1

    Status: VALIDATED

    Source sequence(s)
    AC131803, BB653255
    Consensus CDS
    CCDS51478.1
    UniProtKB/TrEMBL
    D3Z4Z0
    Related
    ENSMUSP00000031097.8, ENSMUST00000031097.8
    Conserved Domains (1) summary
    COG5114
    Location:6 → 415
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    36631014..36641629 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254386.1 → XP_030110246.1  transcriptional adapter 2-beta isoform X1

    UniProtKB/TrEMBL
    D3YW26
    Conserved Domains (1) summary
    COG5114
    Location:11 → 335
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

  2. XM_036165052.1 → XP_036020945.1  transcriptional adapter 2-beta isoform X2

    UniProtKB/TrEMBL
    D3YW26
    Conserved Domains (1) summary
    COG5114
    Location:1 → 323
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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