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Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta [ Mus musculus (house mouse) ]

Gene ID: 231086, updated on 1-Mar-2024

Summary

Official Symbol
Hadhbprovided by MGI
Official Full Name
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit betaprovided by MGI
Primary source
MGI:MGI:2136381
See related
Ensembl:ENSMUSG00000059447 AllianceGenome:MGI:2136381
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mtpb; TP-beta; 4930479F15Rik
Summary
Enables acetyl-CoA C-acyltransferase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to act upstream of or within fatty acid metabolic process. Located in mitochondrion. Is expressed in heart; liver; and placenta. Human ortholog(s) of this gene implicated in mitochondrial metabolism disease and mitochondrial trifunctional protein deficiency. Orthologous to human HADHB (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 131.2), liver E18 (RPKM 32.5) and 15 other tissues See more
Orthologs
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Genomic context

See Hadhb in Genome Data Viewer
Location:
5 B1; 5 16.04 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (30360251..30389591)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30155253..30184593)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 3110082J24 gene Neighboring gene GRB2 associated regulator of MAPK1 subtype 2 Neighboring gene hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha Neighboring gene STARR-positive B cell enhancer ABC_E8045 Neighboring gene microRNA 1960 Neighboring gene adhesion G protein-coupled receptor F3 Neighboring gene STARR-positive B cell enhancer ABC_E1678 Neighboring gene predicted gene, 54326 Neighboring gene selenoprotein I

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetyl-CoA C-acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables acetyl-CoA C-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables acetyl-CoA C-acyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables acetyl-CoA C-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables acetyl-CoA C-myristoyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
 
enables lncRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fatty acid beta-oxidation TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of mitochondrial fatty acid beta-oxidation multienzyme complex IC
Inferred by Curator
more info
PubMed 
part_of mitochondrial fatty acid beta-oxidation multienzyme complex ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
trifunctional enzyme subunit beta, mitochondrial
Names
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta aubunit
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit
NP_001276727.1
NP_001276728.1
NP_663533.1
XP_017176318.1
XP_036020906.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289798.1NP_001276727.1  trifunctional enzyme subunit beta, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001276727.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK033462, AK083767, BE945269, BY337615
    Consensus CDS
    CCDS39045.1
    UniProtKB/Swiss-Prot
    Q3TEH9, Q8BJI5, Q8BJM0, Q8BK52, Q99JY0
    Related
    ENSMUSP00000110431.2, ENSMUST00000114783.6
    Conserved Domains (1) summary
    cd00751
    Location:56472
    thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
  2. NM_001289799.1NP_001276728.1  trifunctional enzyme subunit beta, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001276728.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK150889, BE945269, BY337615, BY778233
    Consensus CDS
    CCDS39045.1
    UniProtKB/Swiss-Prot
    Q3TEH9, Q8BJI5, Q8BJM0, Q8BK52, Q99JY0
    Related
    ENSMUSP00000110434.2, ENSMUST00000114786.8
    Conserved Domains (1) summary
    cd00751
    Location:56472
    thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
  3. NM_145558.2NP_663533.1  trifunctional enzyme subunit beta, mitochondrial precursor

    See identical proteins and their annotated locations for NP_663533.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK150889, BE945269, BY337615
    Consensus CDS
    CCDS39045.1
    UniProtKB/Swiss-Prot
    Q3TEH9, Q8BJI5, Q8BJM0, Q8BK52, Q99JY0
    Related
    ENSMUSP00000026841.9, ENSMUST00000026841.15
    Conserved Domains (1) summary
    cd00751
    Location:56472
    thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    30360251..30389591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165013.1XP_036020906.1  trifunctional enzyme subunit beta, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q3TEH9, Q8BJI5, Q8BJM0, Q8BK52, Q99JY0
    Conserved Domains (1) summary
    cd00751
    Location:56472
    thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
  2. XM_017320829.3XP_017176318.1  trifunctional enzyme subunit beta, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q3TEH9, Q8BJI5, Q8BJM0, Q8BK52, Q99JY0
    Conserved Domains (1) summary
    cd00751
    Location:56472
    thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...