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Hadhb hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit [ Mus musculus (house mouse) ]

Gene ID: 231086, updated on 31-Jan-2019

Summary

Official Symbol
Hadhbprovided by MGI
Official Full Name
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunitprovided by MGI
Primary source
MGI:MGI:2136381
See related
Ensembl:ENSMUSG00000059447
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mtpb; TP-beta; 4930479F15Rik
Expression
Broad expression in heart adult (RPKM 131.2), liver E18 (RPKM 32.5) and 15 other tissues See more
Orthologs

Genomic context

See Hadhb in Genome Data Viewer
Location:
5; 5 B1
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (30155253..30184593)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (30481862..30511123)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 3110082J24 gene Neighboring gene GRB2 associated regulator of MAPK1 subtype 2 Neighboring gene hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit Neighboring gene microRNA 1960 Neighboring gene adhesion G protein-coupled receptor F3 Neighboring gene selenoprotein I Neighboring gene 40S ribosomal protein S25 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
3-hydroxyacyl-CoA dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
NAD binding ISO
Inferred from Sequence Orthology
more info
 
acetyl-CoA C-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acetyl-CoA C-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
acetyl-CoA C-acyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acetyl-CoA C-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enoyl-CoA hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enoyl-CoA hydratase activity ISO
Inferred from Sequence Orthology
more info
 
fatty-acyl-CoA binding ISO
Inferred from Sequence Orthology
more info
 
long-chain-3-hydroxyacyl-CoA dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-chain-3-hydroxyacyl-CoA dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
long-chain-3-hydroxyacyl-CoA dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
long-chain-enoyl-CoA hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-chain-enoyl-CoA hydratase activity ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring acyl groups IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring acyl groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
fatty acid beta-oxidation TAS
Traceable Author Statement
more info
PubMed 
fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial fatty acid beta-oxidation multienzyme complex IC
Inferred by Curator
more info
PubMed 
mitochondrial fatty acid beta-oxidation multienzyme complex ISO
Inferred from Sequence Orthology
more info
 
mitochondrial inner membrane HDA PubMed 
mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
 
mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrion HDA PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
mitochondrion TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
trifunctional enzyme subunit beta, mitochondrial
Names
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta aubunit
NP_001276727.1
NP_001276728.1
NP_663533.1
XP_017176317.1
XP_017176318.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289798.1NP_001276727.1  trifunctional enzyme subunit beta, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001276727.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK033462, AK083767, BE945269, BY337615
    Consensus CDS
    CCDS39045.1
    UniProtKB/Swiss-Prot
    Q99JY0
    Related
    ENSMUSP00000110431.1, ENSMUST00000114783.5
    Conserved Domains (2) summary
    cd00751
    Location:56472
    thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
    TIGR01930
    Location:57471
    AcCoA-C-Actrans; acetyl-CoA acetyltransferases
  2. NM_001289799.1NP_001276728.1  trifunctional enzyme subunit beta, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001276728.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK150889, BE945269, BY337615, BY778233
    Consensus CDS
    CCDS39045.1
    UniProtKB/Swiss-Prot
    Q99JY0
    Related
    ENSMUSP00000110434.1, ENSMUST00000114786.7
    Conserved Domains (2) summary
    cd00751
    Location:56472
    thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
    TIGR01930
    Location:57471
    AcCoA-C-Actrans; acetyl-CoA acetyltransferases
  3. NM_145558.2NP_663533.1  trifunctional enzyme subunit beta, mitochondrial precursor

    See identical proteins and their annotated locations for NP_663533.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK150889, BE945269, BY337615
    Consensus CDS
    CCDS39045.1
    UniProtKB/Swiss-Prot
    Q99JY0
    Related
    ENSMUSP00000026841.8, ENSMUST00000026841.14
    Conserved Domains (2) summary
    cd00751
    Location:56472
    thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
    TIGR01930
    Location:57471
    AcCoA-C-Actrans; acetyl-CoA acetyltransferases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

    Range
    30155253..30184593
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320828.1XP_017176317.1  trifunctional enzyme subunit beta, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q99JY0
    Conserved Domains (2) summary
    cd00751
    Location:56472
    thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
    TIGR01930
    Location:57471
    AcCoA-C-Actrans; acetyl-CoA acetyltransferases
  2. XM_017320829.1XP_017176318.1  trifunctional enzyme subunit beta, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q99JY0
    Conserved Domains (2) summary
    cd00751
    Location:56472
    thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
    TIGR01930
    Location:57471
    AcCoA-C-Actrans; acetyl-CoA acetyltransferases
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