Format

Send to:

Choose Destination

FSTL4 follistatin like 4 [ Homo sapiens (human) ]

Gene ID: 23105, updated on 13-Mar-2020

Summary

Official Symbol
FSTL4provided by HGNC
Official Full Name
follistatin like 4provided by HGNC
Primary source
HGNC:HGNC:21389
See related
Ensembl:ENSG00000053108
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in brain (RPKM 2.5), urinary bladder (RPKM 1.7) and 8 other tissues See more
Orthologs

Genomic context

See FSTL4 in Genome Data Viewer
Location:
5q31.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (133194827..133842066, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (132532152..132948223, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379178 Neighboring gene ribosomal protein L6 pseudogene 15 Neighboring gene uncharacterized CTB-49A3.2 Neighboring gene uncharacterized CTB-3M24.3 Neighboring gene microRNA 1289-2 Neighboring gene dnaJ homolog subfamily C member 24 pseudogene Neighboring gene uncharacterized LOC105379179 Neighboring gene uncharacterized LOC105379182 Neighboring gene WNT signaling pathway activating non-coding RNA

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide linkage and association scan reveals novel loci for hypertension and blood pressure traits.
NHGRI GWA Catalog
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
brain-derived neurotrophic factor binding IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of brain-derived neurotrophic factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of collateral sprouting IEA
Inferred from Electronic Annotation
more info
 
negative regulation of dendritic spine development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
secretory granule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
follistatin-related protein 4
Names
follistatin-like protein 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015082.2NP_055897.1  follistatin-related protein 4 precursor

    See identical proteins and their annotated locations for NP_055897.1

    Status: VALIDATED

    Source sequence(s)
    AB028984, AC005195, AC010307, BC024300
    Consensus CDS
    CCDS34238.1
    UniProtKB/Swiss-Prot
    Q6MZW2
    Related
    ENSP00000265342.7, ENST00000265342.12
    Conserved Domains (6) summary
    cd05736
    Location:358433
    Ig2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a follistatin-like molecule encoded by the Mahya gene and similar proteins
    smart00408
    Location:265326
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:256337
    IG_like; Immunoglobulin like
    cd00104
    Location:93133
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam07679
    Location:341430
    I-set; Immunoglobulin I-set domain
    cl08302
    Location:180250
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    133194827..133842066 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543283.1XP_011541585.1  follistatin-related protein 4 isoform X1

    See identical proteins and their annotated locations for XP_011541585.1

    UniProtKB/Swiss-Prot
    Q6MZW2
    Conserved Domains (6) summary
    cd05736
    Location:358433
    Ig2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a follistatin-like molecule encoded by the Mahya gene and similar proteins
    smart00408
    Location:265326
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:256337
    IG_like; Immunoglobulin like
    cd00104
    Location:93133
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam07679
    Location:341430
    I-set; Immunoglobulin I-set domain
    cl08302
    Location:180250
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  2. XM_011543284.2XP_011541586.1  follistatin-related protein 4 isoform X2

    Conserved Domains (6) summary
    cd05736
    Location:358433
    Ig2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a follistatin-like molecule encoded by the Mahya gene and similar proteins
    smart00408
    Location:265326
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:256337
    IG_like; Immunoglobulin like
    cd00104
    Location:93133
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam07679
    Location:341430
    I-set; Immunoglobulin I-set domain
    cl08302
    Location:180250
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  3. XM_011543286.3XP_011541588.1  follistatin-related protein 4 isoform X3

    Conserved Domains (5) summary
    cd05736
    Location:217292
    Ig2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a follistatin-like molecule encoded by the Mahya gene and similar proteins
    smart00408
    Location:124185
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:115196
    IG_like; Immunoglobulin like
    pfam07679
    Location:200289
    I-set; Immunoglobulin I-set domain
    cl08302
    Location:39109
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  4. XM_011543287.2XP_011541589.1  follistatin-related protein 4 isoform X5

    Conserved Domains (2) summary
    cd05736
    Location:43118
    Ig2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a follistatin-like molecule encoded by the Mahya gene and similar proteins
    pfam07679
    Location:26115
    I-set; Immunoglobulin I-set domain
  5. XM_017009251.1XP_016864740.1  follistatin-related protein 4 isoform X4

Support Center