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Plekhn1 pleckstrin homology domain containing, family N member 1 [ Mus musculus (house mouse) ]

Gene ID: 231002, updated on 4-Jan-2025

Summary

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Official Symbol
Plekhn1provided by MGI
Official Full Name
pleckstrin homology domain containing, family N member 1provided by MGI
Primary source
MGI:MGI:2387630
See related
Ensembl:ENSMUSG00000078485 AllianceGenome:MGI:2387630
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Clpabp
Summary
Predicted to enable phospholipid binding activity. Involved in 3'-UTR-mediated mRNA destabilization. Located in mitochondrion. Orthologous to human PLEKHN1 (pleckstrin homology domain containing N1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in stomach adult (RPKM 22.9), thymus adult (RPKM 14.5) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Plekhn1 in Genome Data Viewer
Location:
4 E2; 4 88.63 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (156305913..156312999, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (156221456..156228542, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2735 Neighboring gene expressed sequence AW011738 Neighboring gene PPARGC1 and ESRR induced regulator, muscle 1 Neighboring gene predicted gene, 46877 Neighboring gene kelch-like 17 Neighboring gene microRNA 7658 Neighboring gene STARR-seq mESC enhancer starr_12292 Neighboring gene NOC2 like nucleolar associated transcriptional repressor Neighboring gene predicted gene, 52691

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Antagonizing effect of CLPABP on the function of HuR as a regulator of ARE-containing leptin mRNA stability and the effect of its depletion on obesity in old male mouse. Nishino T, et al. Biochim Biophys Acta, 2016 Nov. PMID 27616329
  2. Bioinformatics and cellular signaling. Papin J, et al. Curr Opin Biotechnol, 2004 Feb. PMID 15102471
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cardiolipin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cardiolipin binding ISO
Inferred from Sequence Orthology
more info
  
enables cardiolipin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidic acid binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylinositol phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol phosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylserine binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA destabilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 3'-UTR-mediated mRNA destabilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in 3'-UTR-mediated mRNA destabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to hypoxia IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
involved_in response to hypoxia ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable pleckstrin homology domain-containing family N member 1
Names
PH domain-containing family N member 1
cardiolipin and phosphatidic acid-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008233.3 → NP_001008234.2  probable pleckstrin homology domain-containing family N member 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    CAAA01066807
    Consensus CDS
    CCDS51407.1
    UniProtKB/TrEMBL
    E9QP36
    Related
    ENSMUSP00000101196.3, ENSMUST00000105571.4
    Conserved Domains (2) summary
    pfam00169
    Location:243 → 322
    PH; PH domain
    cl17171
    Location:223 → 341
    PH-like; Pleckstrin homology-like domain

  2. NM_001368639.1 → NP_001355568.1  probable pleckstrin homology domain-containing family N member 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CAAA01066807
    Consensus CDS
    CCDS89875.1
    UniProtKB/Swiss-Prot
    A0A1W2P6Q7, A0A1W2P7X5, Q8C886, Q8R3H1
    Related
    ENSMUSP00000151799.2, ENSMUST00000217885.2
    Conserved Domains (1) summary
    cl17171
    Location:223 → 341
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    156305913..156312999 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C886.2 GenPept UniProtKB/Swiss-Prot:Q8C886

Gene LinkOut

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