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Emc1 ER membrane protein complex subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 230866, updated on 26-Mar-2024

Summary

Official Symbol
Emc1provided by MGI
Official Full Name
ER membrane protein complex subunit 1provided by MGI
Primary source
MGI:MGI:2443696
See related
Ensembl:ENSMUSG00000078517 AllianceGenome:MGI:2443696
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2700016F22Rik
Summary
Predicted to contribute to membrane insertase activity. Predicted to be involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Located in endoplasmic reticulum. Is expressed in lung. Orthologous to human EMC1 (ER membrane protein complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 16.2), ovary adult (RPKM 15.3) and 28 other tissues See more
Orthologs
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Genomic context

Location:
4 D3; 4 70.66 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (139079898..139106046)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (139352587..139378735)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene cyclin D3, pseudogene Neighboring gene mRNA turnover 4, ribosome maturation factor Neighboring gene STARR-seq mESC enhancer starr_11828 Neighboring gene STARR-seq mESC enhancer starr_11829 Neighboring gene STARR-seq mESC enhancer starr_11830 Neighboring gene ubiquitin protein ligase E3 component n-recognin 4 Neighboring gene nuclear encoded tRNA valine 1 (anticodon AAC) Neighboring gene intermediate filament family orphan 2 Neighboring gene VISTA enhancer mm1506 Neighboring gene STARR-seq mESC enhancer starr_11836 Neighboring gene STARR-positive B cell enhancer ABC_E6246

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: Ubr4

Clone Names

  • KIAA0090, RP23-371E13.1

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to membrane insertase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of EMC complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of EMC complex ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
ER membrane protein complex subunit 1
Names
novel DUF1620 domain containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039200.2NP_001034289.1  ER membrane protein complex subunit 1 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
    Source sequence(s)
    AK049061, AK089289, AL807833, BY281473
    Consensus CDS
    CCDS18846.1
    UniProtKB/TrEMBL
    Z4YJW0
    Related
    ENSMUSP00000049034.8, ENSMUST00000042096.15
    Conserved Domains (2) summary
    pfam07774
    Location:788993
    DUF1620; Protein of unknown function (DUF1620)
    pfam13360
    Location:63254
    PQQ_2; PQQ-like domain
  2. NM_146157.4NP_666269.2  ER membrane protein complex subunit 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_666269.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK049061, AL807833, BY281473
    Consensus CDS
    CCDS38933.1
    UniProtKB/Swiss-Prot
    B2RTJ5, Q3TCG4, Q6ZQJ4, Q8C7X2, Q8K3W8
    UniProtKB/TrEMBL
    A1L2Z3
    Related
    ENSMUSP00000137103.2, ENSMUST00000179784.9
    Conserved Domains (2) summary
    pfam07774
    Location:791996
    DUF1620; Protein of unknown function (DUF1620)
    pfam13360
    Location:63254
    PQQ_2; PQQ-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    139079898..139106046
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)