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Fam76a family with sequence similarity 76, member A [ Mus musculus (house mouse) ]

Gene ID: 230789, updated on 26-Sep-2022

Summary

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Official Symbol
Fam76aprovided by MGI
Official Full Name
family with sequence similarity 76, member Aprovided by MGI
Primary source
MGI:MGI:2385211
See related
Ensembl:ENSMUSG00000028878 AllianceGenome:MGI:2385211
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be located in nucleoplasm. Is expressed in embryo. Orthologous to human FAM76A (family with sequence similarity 76 member A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 26.9), bladder adult (RPKM 9.4) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Fam76a in Genome Data Viewer
Location:
4; 4 D2.3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132626524..132650081, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (132899213..132922760, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene syntaxin 12 Neighboring gene prostaglandin-endoperoxide synthase 2 pseudogene Neighboring gene predicted gene, 36518 Neighboring gene FGR proto-oncogene, Src family tyrosine kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
  2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (17) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC11672

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein FAM76A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163792.1 → NP_001157264.1  protein FAM76A isoform B

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, which results in a shorter protein (isoform B), compared to isoform A.
    Source sequence(s)
    AK037828, AK038831, BY415109
    Consensus CDS
    CCDS51320.1
    UniProtKB/Swiss-Prot
    Q922G2
    Related
    ENSMUSP00000095468.4, ENSMUST00000097856.10
    Conserved Domains (1) summary
    pfam16046
    Location:4 → 263
    FAM76; FAM76 protein

  2. NM_145553.2 → NP_663528.1  protein FAM76A isoform A

    See identical proteins and their annotated locations for NP_663528.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A).
    Source sequence(s)
    AK037828, AK038831, BY415109
    Consensus CDS
    CCDS18738.1
    UniProtKB/Swiss-Prot
    Q3V3N2, Q922G2
    Related
    ENSMUSP00000030696.5, ENSMUST00000030696.11
    Conserved Domains (1) summary
    pfam16046
    Location:4 → 292
    FAM76; FAM76 protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    132626524..132650081 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538733.5 → XP_006538796.1  protein FAM76A isoform X1

    Conserved Domains (1) summary
    pfam16046
    Location:4 → 335
    FAM76; FAM76 protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q922G2.1 GenPept UniProtKB/Swiss-Prot:Q922G2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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